Endocrine and metabolic disorders in women with polycystic ovary syndrome and new possibilities of their correction

Authors

  • Г. Б. Семенина Lviv National Medical University named after Danylo Galitskyi, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2016.32.69-76

Keywords:

polycystic ovary syndrome, hyperandrogenia, insulin resistance, hyperinsulinemia, D-Chiro-inositol

Abstract

The article presents the results of a survey of hormonal and exchange-metabolic balance in women with polycystic ovary syndrome (PCOS). Under supervision there were 67 women with PCOS and 30 healthy women (control group). Depending on the body mass index of patients they were also divided into the corresponding subgroups.

Analysis of results of exchange-metabolic surveys revealed that the clinical phenotype of PCOS with overweight characterized by a next combination: insulin resistance on an empty stomach, decreased insulin sensitivity, additive hyperinsulinemia and disorder of glucose utilization, high basal levels of cortisol and its suppression after glucose load, dyslipidemia with increased level of total cholesterol, lipoproteins low and very low density, triglycerides on an empty stomach and after load, and decreased level of high density lipoprotein. The clinical phenotype of PCOS with normal body weight was characterized by a tendency to abdominal accumulation of fat in the absence of excessive body weight, decreased the metabolic clearance of glucose and increased level of the two-hour glucose tolerance test of insulin and glucose on an empty stomach, basal hypercortisolemia and suppression of cortisol on the background of a glucose load, and dyslipidemia in the form of reduced levels of high density lipoproteins.

These changes are possible risk factors for the formation in women with PCOS the cardiovascular diseases, type II diabetes, and during pregnancy – gestational diabetes. In addition, women with PCOS are more likely to develop pregnancy complications such as miscarriage, fetal growth retardation syndrome, hypertension, the induced pregnancy and pre-eclampsia.

In order to prevent pregnancy complications in these women used the combined drug mesix containing a D-Chiro-inositol within 6 months. Evaluation of clinical and laboratory efficacy of treatment showed a positive effect on the menstrual cycle in 57.4%, on the hormonal balance in 78.9% and on exchange-metabolic disorders in 63.2% of patients with PCOS. In this connection, the author points out the need to study the effectiveness of a long-term use of this drug, taking into account its security and economic adequacy.

Author Biography

Г. Б. Семенина, Lviv National Medical University named after Danylo Galitskyi

PhD, assistant professor of Obstetrics and Gynecology Department

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Published

2016-12-29

How to Cite

Семенина, Г. Б. (2016). Endocrine and metabolic disorders in women with polycystic ovary syndrome and new possibilities of their correction. REPRODUCTIVE ENDOCRINOLOGY, (32), 69–76. https://doi.org/10.18370/2309-4117.2016.32.69-76

Issue

No. 32 (2016)

Section

Reproductive endocrinology

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Copyright (c) 2016 Г. Б. Семенина

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