Епідеміологія ВПЛ-інфекції в Україні

А. А. Суханова; І. В. Сідорова; Г. І. Сиротинська; О. А. Бурка

doi:10.18370/2309-4117.2016.32.39-44

Authors

А. А. Суханова P.L. Shupik National Medical Academy of the Postgraduate Education, Ukraine https://orcid.org/0000-0001-7387-3994
І. В. Сідорова Medical Laboratory DILA, Ukraine https://orcid.org/0000-0002-6742-5033
Г. І. Сиротинська Medical Laboratory DILA, Ukraine https://orcid.org/0000-0003-1153-5599
О. А. Бурка Bogomolets National Medical University, Ukraine https://orcid.org/0000-0003-0133-9885

DOI:

https://doi.org/10.18370/2309-4117.2016.32.39-44

Keywords:

human papillomavirus (HPV), HPV infection, cervical intraepithelial lesions, Pap test liquid-based cytology

Abstract

The article presents data on the prevalence of humanpapilloma virus (HPV) in Ukraine on the basis of studies of more than 40 000 women of different ages, surveyed in a medical laboratory DILA for the period from 2014 to 2016. Researchers was studied the features of the structure of identification of high risk genotypes of HPV with mild, moderate and severe degree of cervical intraepithelial neoplasia (CIN).

Among all surveyed the number of women with HPV was 34%, the majority of which (65%) were infected with high risk HPV genotypes, and in 90% of cases it was mixed infection.

The structure of the detection of various high risk HPV genotypes in Ukraine is: 16th genotype – 23%, 53th genotype – 16%, 31th genotype – 14%, 33th genotype – 11%, 66th genotype – 11%, 68th genotype – 11%. The greatest proportion of HPV-infected women had an young age (less than 20 years and 20–29 years). It was also found an interesting pattern: then the more severe was the degree of damage to the epithelium, the lower was range of detection of genotypes. If in CIN I were recorded more than 11 kinds of genotypes, and in CIN II – up to 10, and in CIN III – only 3 genotypes. Moreover, the number of cases of mixed infections was reduced with increasing severity of intraepithelial lesions.

Regardless of the severity of intraepithelial lesions the largest share of infected with human papilloma virus Ukrainian women accounted for 16th genotype: 24% with CIN I, 61% – with CIN II, and 70% – with CIN III. Further, among the most common genotypes were 31th, 33th and 18th. Thus, we can assume that in Ukraine the 16th, 31th, 33th and 18th genotypes associated with various degrees of CIN, i.e. women which is infected with these genotypes make up a high-risk group.

Author Biographies

А. А. Суханова, P.L. Shupik National Medical Academy of the Postgraduate Education

MD, professor at the Obstetrics, Gynecology and Reproductology Department

І. В. Сідорова, Medical Laboratory DILA

Medical director

Г. І. Сиротинська, Medical Laboratory DILA

PhD, specialist at the medical department

О. А. Бурка, Bogomolets National Medical University

PhD, assistant of the Obstetrics and Gynaecology Department №1

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