Local treatment of nonspecific vulvovaginitis in puberty is the treatment of choice





nonspecific vulvovaginitis, puberty, local treatment, Depantol


Infection of the sexual sphere, in particular vaginitis occupy a leading place in the structure of gynecological morbidity in puberty. Diseases of the female genital organs, which appear even before the first pregnancy in adolescent girls lead to a high frequency of complications at labor, the increase of perinatal morbidity and mortality.

The aim of the study was to evaluate the efficacy of the Depantol for the treatment of non-specific vulvovaginitis in puberty young people with sexually active behavior.

Under supervision there were 30 girls aged 16–18 who are living an irregular sexual life. The diagnosis of non-specific vulvovaginitis verified according to clinical and laboratory studies. All patients was prescribed the drug Depantol by 1 suppository 2 times a day for 10 days. Treatment efficacy was evaluated according to the clinical examination before treatment, at 5 and 10 days of observation, as well as laboratory data before treatment and at 1 and 3 months after treatment.

The main complaint of the study participants was abnormal vaginal discharges (96.7%). Itching bothered 80% of patients, vaginal mucosa edema were observed in 90% of girls, hyperemia – in 70%. After treatment the itching and swelling in the vaginal area ceased to disturb 100% of patients, but in 6.7% of cases the abnormal vaginal discharges and hyperemia remained. Bacterial investigation at one month after treatment confirmed the efficacy of the proposed treatment for 90% of girls. Clinical and bacteriological studies at 3 months after treatment showed the presence of clinical signs of disease recurrence in 20% of patients who at the same time were accompanied by the positive results of plantings. Compared with literature data where relapses were observed in 50% of patients, it is a fairly good indicator.

The results of study show that the drug Depantol is highly effective to major pathogens of inflammatory non-specific vulvovaginitis. Depantol does not violate the functional activity of lactic acid bacteria, which contributes to the maintenance of normal biocenosis of the vagina. Thus, the local treatment of non-specific vulvovaginitis in sexually active young people under 18 years is an effective, safe and may be considered as therapy of choice.

Author Biography

О. В. Кравченко, Bukovinian State Medical University

MD, professor, Head of the Obstetrics, Gynecology and Perinatology Department


  1. Plotko, E.E., Donnikov, A.E., Voroshilina, E.S., et al. “Vaginal biocenosis in terms of quantitative PCR: what is the norm?” Obstetrics and Gynecology 1 (2011): 66–70.
  2. Infections in obstetrics and gynecology. Ed. by O.V. Makarov, V.A. Aleshkin, T.N. Savchenko. Moscow. MEDpress-inform (2007): 177–89.
  3. Kira, E.F., Muslimova, S.Z. “The non-specific vaginitis and its impact on women’s reproductive health (the literature review).” Problems of reproduction 5 (2008): 8–13.
  4. Kira, E.F., Berlev, I.V., Molchanov, O.L. “The course of pregnancy, childbirth and the postpartum period in women with dysbiotic vaginal disorders.” Journal of obstetrics and gynecological diseases 2 Vol. XLVII (1999): 8–11.
  5. Radzinskyi, V.E., Khamoshina, M.B., Kaigorodova, L.A., et al. “Correction of vaginal biocenosis: march in place or move forward?” Reproductive Endocrinology 4.18 (2014): 92–100.
  6. Korshunov, V.M., Volodin, N.N., Efimov, B.A., et al. Microecology of vagina. Correction of microflora at vaginal dysbacteriosis. Tutorial. Moscow (1999): 79 p.
  7. Savitskaya, K.I., Vorobyov, A.A., Molochkov, V.A., Zur, N.V. “The normal flora of the genital tract of healthy reproductive age women.” Herald of RAMS 9 (2003): 48–52.
  8. Romashchenko, O.V., Lebed, L.A., Yakovenko, L.F., et al. “Revaluation of approaches to diagnosis and treatment of inflammatory diseases of the genitals caused by mixed infection.” Health of woman 5 (2009): 161–8.
  9. Radzinskyi, V.E. “Correction of microbiocenosis of urogenital tract.” Pharmacotherapy in obstetrics and gynecology 4 (2009): 44–6.
  10. Radzinskyi, V.E., et al. “Effective correction of vaginal biocenosis disorders out and during pregnancy: why it is important and what’s new? Doktor.Ru 58.7 Part 1 Gynecology (2010): 20–6.
  11. Yamamoto, T., Zhou, X., Williams, C.J., et al. “Bacterial populations in the vaginas of healthy adolescent women.” J Pediatr Adolesc Gynecol 22 (2009): 11–18.
  12. Brown, C.J., et al. “Preliminary characterization of the normal microbiota of the human vulva using cultivation independent methods.” J Med Microbiol 56.2 (2007): 271–6.
  13. Workowski, K.A., Berman, S. “Sexually transmitted diseases treatment guidelines.” MMWR Recomm Rep 59 (2010): 101–10.



How to Cite

Кравченко, О. В. (2016). Local treatment of nonspecific vulvovaginitis in puberty is the treatment of choice. REPRODUCTIVE ENDOCRINOLOGY, (32), 24–28. https://doi.org/10.18370/2309-4117.2016.32.24-28



Inflammatory diseases