The effectiveness of micronized progesterone sublingual and vaginal forms combined use in the treatment of preterm labor
DOI:
https://doi.org/10.18370/2309-4117.2016.27.41-46Keywords:
the threat preterm labor, sublingual form of micronized progesterone, luteina, vaginal form of micronized progesterone, oil progesteroneAbstract
The article presents current data about the peculiarities of etiology and pathogenesis, clinics and treatment of preterm labor. The results of the clinical study of the effectiveness of micronized progesterone sublingual and vaginal forms for combined therapy of preterm labor at 22–30 weeks were described.
The study included 60 pregnant women. All patients were divided into 2 groups.
Group I consisted of 30 pregnant women who received magnesian tocolytic therapy; hormone therapy (sublingual form of micronized progesterone, along with a third receiving sublingual form the vaginal form of micronized progesterone was administered), systemic anti-inflammatory therapy.
Group II consisted of 30 pregnant women who received magnesian tocolytic therapy; hormone therapy (oily solution progesterone i.m.), systemic anti-inflammatory therapy.
Discontinuation of progesterone carried out with the 8th day gradually, under the control of ultrasound examination, according to the clinical status of the pregnant.
Following parameters were evaluated: gynecological and obstetric history, complaints, laboratory values, ultrasound parameters, peculiarities of childbirth and the postpartum period.
In the course of treatment there is a rapid regression of clinical symptoms in the first study group. The rates of recovery of normal myometrium tone in the first group were also faster than in the second group. These results indicate better perinatal perspectives in patients treated with combination therapy of preterm labor with the sublingual form of vaginal micronized progesterone compared with pregnant women who received oily solution progesterone i.m.
Thus, sublingual form of micronised progesterone and magnesium therapy during the clinical symptoms of preterm labor has a rapid therapeutic effect and prevent the further progression of structural cervix changes during treatment and in the secondary prevention of preterm birth in women with short cervix (less than 20 mm).
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Copyright (c) 2016 О. В. Голяновський, А. М. Рубінштейн, М. А. Бачинська
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