Detection of proliferative potential in ectopic endometrium in women with different forms of endometriosis

Authors

  • Н. Ф. Захаренко Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2015.22.22-24

Keywords:

ectopic endometrium, endometriosis, proliferating cell nuclear antigen, carcino-embryonic antigen

Abstract

To investigate the proliferative potential in ectopic endometrium was determined by immunohistochemistry the expression of proliferating cell nuclear antigen (PCNA), which is considered a factor in the growth of tumors. In ectopic endometrium also determined the expression of carcino-embryonic antigen (CEA), which is considered a predictor of malignancy of tumors.

Histological examination of extirpation uterus was conducted in 35 women of first groups with internal endometriosis, the second group consisted of 52 patients with external endometriosis and the third group consisted of 19 patients with extragenital endometriosis, which was performed resection of endometriosis lesions.

The study revealed that the majority of endometrial ectopia was CEA-negative, on the basis of which we can speak of a low propensity to malignancy potential of all forms of endometriosis.

Lack of expression of CEA in all patients with extragenital endometriosis may indicate the lowest probability of malignant transformation of endometrioid heterotopias is in their extragenital localization

Author Biography

Н. Ф. Захаренко, Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine

MD, chief researcher at the Endocrine Gynecology Department

References

  1. Adamyan, L.V., Loginova, O.N., Sonova, M.M. “Optimization of treatment of external genital endometriosis with antioxidant agents.” Health and Education in Siberia online. 14.00.00: Medical and Pharmaceutical Sciences, 4(2012): 74–76.
  2. Lyzyn, M.A., Nykolyn, N.B., Drin, T.M. Current views on the etiology, pathogenesis, clinic, diagnostics of endometriosis // Galician Medical Bulletin, 2(2006): 113–119.
  3. Beutel, M.E., Weidner, K., Brohler, E. “Chronic pelvic pain of Women and its Co-Morbidity.” Geburtsh Frauenheilk, 65(2005): 61–67.
  4. Brown, M.A., Edwards, S., Hoyle, E., Campbell, S., Laval, S., Daly, A.K., et al. “Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis.” Hum Mol Genet, 9(2000): 1563–1566.
  5. Flor, H., Turk, D.C., eds. Chronic pain: An Integrated Biobehavioral Approach. London. Informa Healthcare Publishing Group (2011).
  6. Hassa, H. “Apoptosis patterns in eutopic and ectopic endometrium, adhesions and normal-looking peritoneum from women with or without endometriosis.” Arch Gynecol Obstet, 2(280) (2009): 195–199.

Downloads

Published

2015-04-14

How to Cite

Захаренко, Н. Ф. (2015). Detection of proliferative potential in ectopic endometrium in women with different forms of endometriosis. REPRODUCTIVE ENDOCRINOLOGY, (22), 22–24. https://doi.org/10.18370/2309-4117.2015.22.22-24

Issue

No. 22 (2015)

Section

Gynecology

License

Copyright (c) 2015 Н. Ф. Захаренко

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.