Nutritional support for women’s health under chronic stress (micronutrient supplementation)

Literature review

Authors

DOI:

https://doi.org/10.18370/2309-4117.2026.82.84-94

Keywords:

nutrients, micronutrient status, nutritional support, chronic stress, women’s reproductive health

Abstract

Background. Women’s reproductive health is highly vulnerable to nutritional deficiencies, which are exacerbated under crisis conditions. Despite the evident role of nutrients, integrated strategies for personalized nutritional correction are still lacking in domestic gynecological practice.

Objective of the review: to substantiate the role of micronutrient status in maintaining the adaptive potential of women under chronic stress conditions and to identify strategies for personalized nutritional management.

Materials and methods. A systematic review of the literature (PubMed and Google Scholar databases) on the nutritional status of women published from March 2015 to March 2025 was conducted. A narrative review and comparative analysis of the biological value of foods were used.

Analysis of literature data. Based on the literature review, it was found that 70–80% of women worldwide suffer from multiple vitamin deficiencies. Studies on iodine and selenium demonstrate their fundamental role not only in thyroid homeostasis but also in the prevention of estrogen-dependent breast diseases.

Under chronic stress conditions, adequate intake of magnesium and zinc is critical for modulation of the nervous and immune systems, as well as metabolic status. Even with a conscious approach to nutrition, modern women face the problem of the “phytate barrier” and low bioavailability of iron. Under conditions of internal displacement and economic instability, the diet often becomes monotonous (predominantly grain-based). This explains why iron deficiency anemia remains an epidemic problem despite the availability of food products. Stress closes a vicious circle: nutrient deficiencies lower the threshold of stress resilience, and each new stressful event further depletes micronutrient stores.

Conclusions. The implementation of integrated supplementation strategies using multivitamin and mineral complexes is a necessary step to preserve women’s reproductive and somatic health under chronic stress.

Author Biographies

D.H. Herman, Municipal Non-Profit Enterprise of the Mykolaiv City Council “City Hospital No. 1”, Mykolaiv

PhD, obstetrician-gynecologist

T.F. Tatarchuk, SI “Ukrainian Center of Maternity and Childhood of the NAMS of Ukraine”; National Medical University “Center for Innovative Medical Technologies of the NAS of Ukraine”, Kyiv

DSc, professor, corresponding member of the NAMS of Ukraine, deputy general director, head of the Department of Endocrine Gynecology
chief research fellow, Department of Reproductive Health

L.V. Kaluhina, SI «Ukrainian Center of Maternity and Childhood of the NAMS of Ukraine»; SI «Center for Innovative Medical Technologies of the NAS of Ukraine», Kyiv

DSc, professor, leading researcher, Department of Endocrine Gynecology
chief researcher, Department of Reproductive Health

T.I. Yusko, SI «Ukrainian Center of Maternity and Childhood of the NAMS of Ukraine», Kyiv

PhD, senior researcher, Department of Endocrine Gynecology

O.H. Parkhomenko, SI «Ukrainian Center of Maternity and Childhood of the NAMS of Ukraine», Kyiv

junior researcher, Department of Endocrine Gynecology

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2026-04-18

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Herman, D., Tatarchuk, T., Kaluhina, L., Yusko, T., & Parkhomenko, O. (2026). Nutritional support for women’s health under chronic stress (micronutrient supplementation): Literature review. REPRODUCTIVE ENDOCRINOLOGY, (82), 84–94. https://doi.org/10.18370/2309-4117.2026.82.84-94

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No. 82 (2026)

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Interdisciplinary problems

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