Experience of correction of latent (non-anaemic) iron deficiency in adolescent girls and young women

Authors

DOI:

https://doi.org/10.18370/2309-4117.2025.81.27-34

Keywords:

iron deficiency, sex hormones, erythrocytes, vaginal microbiome, quality of life, correction, preparation of iron (III) hydroxide-polymaltose complex

Abstract

Objective of the study: to evaluate the effectiveness of treatment and quality of life of adolescent girls and young women with latent iron deficiency using the iron (III) hydroxide-polymaltose complex.
Materials and methods. 654 women aged 16–20 years were examined: 55 patients (8.4%) were diagnosed with iron deficiency anemia, 342 (52.3%) did not have iron deficiency, 257 (39.3%) had latent iron deficiency, of whom 37 used the iron (III) hydroxide-polymaltose complex for 3 months (study group). 83 women without iron deficiency were included in the control group.
The levels of ferritin, serum iron, C-reactive protein, malondialdehyde and phospholipids in erythrocytes, permeability of erythrocyte membranes, catecholamine and insulin-depositing function of erythrocytes, sex hormones, cortisol, immunoglobulin A, the state of the vaginal microbiome and quality of life were determined.
Results. In patients with latent iron deficiency, changes in the functional state of various organs and systems were found, and quality of life was reduced compared to individuals without iron deficiency. The use of the iron (III) hydroxide-polymaltose complex in this cohort high effectiveness in restoring ferritin and serum iron levels, which contributed to the normalization of the hormonal profile and lipid peroxidation in erythrocytes, the function and structure of erythrocyte membranes, the restoration of the vaginal microbiome and immunoglobulin A and the quality of life.
Conclusions: The use of the iron (III) hydroxide-polymaltose complex has shown its effectiveness in correcting latent iron deficiency and its consequences, thus improving the quality of life of patients.

Author Biographies

G.I. Reznichenko, Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia

MD, professor, Department of Obstetrics, Gynecology and Reproductive Medicine

R.A. Tursunov, Tajik National University, Dushanbe

PhD, deputy dean for science and international relations, Faculty of Medicine

Y.G. Reznichenko, Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia

MD, professor, Department of Hospital Pediatrics

S.A. Smiyan, Sumy National University, Sumy

PhD, associate professor, Department of Obstetrics, Gynecology and Family Planning

O.O. Gordiychuk, Vinnytsia National Medical University named after M.I. Pirogov, Vinnytsia

PhD, associate professor, Department of Nervous Diseases

N.F. Odinaeva, Istiklol City Health Center, Dushanbe

MD, obstetrician-gynecologist, Intensive Care Unit

A.V. Borodin, Territorial Medical Association “Healthy Family”, Zaporizhzhia

head of the Hematology Department

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Published

2025-12-30

How to Cite

Reznichenko, G., Tursunov, R., Reznichenko, Y., Smiyan, S., Gordiychuk, O., Odinaeva, N., & Borodin, A. (2025). Experience of correction of latent (non-anaemic) iron deficiency in adolescent girls and young women. REPRODUCTIVE ENDOCRINOLOGY, (81), 27–34. https://doi.org/10.18370/2309-4117.2025.81.27-34

Issue

No. 81 (2025)

Section

Gynecology

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