Resolution of the III Ukrainian Forum of Experts on Abnormal Uterine Bleeding
DOI:
https://doi.org/10.18370/2309-4117.2025.79.8-16Keywords:
abnormal uterine bleeding, resolution, Ukrainian Forum of Experts on Abnormal Uterine BleedingAbstract
Abnormal uterine bleeding (AUB) is the leading reason for seeking medical attention among women aged 30 to 50. Given the demographic crisis that Ukraine is currently facing, there is
an urgent need to develop a strategy to preserve the reproductive health of the population and update the national regulatory framework. This should take into account modern scientific achievements to unify clinical approaches.
The resolution of this Forum aims to improve clinical approaches to the management of patients with menstrual disorders and AUB, to implement personalized treatment, which is designed to improve the reproductive health of Ukrainian women in conditions of full-scale war.
The resolution summarizes the recommendations of international associations, highlights the advantages of using gestagens in the treatment of AUB, applies an interdisciplinary approach to discussing AUB management - from hematological and endocrinological perspectives, and considers the issue of prevention of venous thromboembolic complications in gynecological patients. In order to optimize the management of patients with AUB, the Forum experts improved the AUB management algorithm. The main difference was the clarification of the period for which the patient has a request and willingness to take contraceptives.
The main direction of AUB pharmacotherapy is the use of hormonal drugs such as combined oral contraceptives and gestagens. Among gestagens, high efficacy and safety of dydrogesterone has been proven. Given the fact that most patients with AUB have concomitant pathology, interdisciplinary cooperation and integration of a patient-oriented approach are important, which is the key to preserving the reproductive potential of Ukrainian women.
References
- Simoncini T, Arab H, Pedachenko N, et al. Unmet needs in abnormal uterine bleeding due to ovulatory dysfunction. Gynecol Endocrinol. 2024 Dec;40(1):2362244. DOI: 10.1080/09513590.2024.2362244
- Results of the qualitative-quantitative study: Duphaston® – the role of the drug in MC disirders and Endometriosis. UMG, 2023.
- Mikes BA, Vadakekut ES, Sparzak PB. Abnormal Uterine Bleeding. [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532913/
- Munro MG, Critchley HOD, Fraser IS; FIGO Menstrual Disorders Committee. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynaecol. Obstet. 2018; 143:393–408. DOI: 10.1002/ijgo.12666
- NICE guideline. Heavy menstrual bleeding: assessment and management [Internet]. NICE. 14 March 2018. Available from: https://www.nice.org.uk/guidance/ng88.
- Munro MG, Balen AH, Cho S, et al. The FIGO Ovulatory Disorders Classification System. Fertil Steril. 2022;118(4):768–86. DOI:10.1016/j.fertnstert.2022.07.009
- Brun JL, Plu-Bureau G, Huchon C, et al. Management of women with abnormal uterine bleeding: Clinical practice guidelines of the French National College of Gynaecologists and Obstetricians (CNGOF). Eur J Obstet Gynecol Reprod Biol. 2023;288:90–107. DOI:10.1016/j.ejogrb.2023.07.001
- Dangal G. Menstrual disorders in adolescents [Internet]. The Internet Journal of Gynecology and Obstetrics 2004; 4:1. Available from: https://ispub.com/ijgo/4/1/7501
- Brenner PF. Differential diagnosis of abnormal uterine bleeding. Am J Obstet Gynecol. 1996; 175:766–9. DOI: 10.1016/s0002-9378(96)80082-2
- Farrell E. Dysfunctional uterine bleeding. Aust Fam Physician. 2004; 33:906–8
- Boutzios G, Karalaki M, Zapanti E. Common pathophysiological mechanisms involved in luteal phase deficiency and polycystic ovary syndrome. Impact on fertility. Endocrine. 2013; 43(2):314–7. DOI: 10.1007/s12020-012-9778-9.
- Gautray JP, Colin MC, Vielh JP, de Brux J. Luteal Insufficiency: Endometrial and Endocrine Correlates. In: de Brux J, Gautray JP, eds. The Endometrium. New York, NY: Plenum Press; 1981:109-122. DOI:10.1007/978-1-4684-3977-9_8.
- Conforti A, Yousif A, Hong L, Chefetz I. Premature ovarian insufficiency: pathogenesis and therapeutic potential of stem cell therapy. J Mol Med. 2021; 99(5):645–62. DOI:10.1007/s00109-021-02055-5.
- Practice Committee of the American Society for Reproductive Medicine Fertility evaluation of infertile women: a committee opinion. Fertil Steril. 2021 Nov;116(5):1255–65 DOI: 10.1016/j.fertnstert.2021.08.038
- Munro MG, Critchley HO, Broder MS, Fraser IS; FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet. 2011 Apr;113(1):3–13. DOI: 10.1016/j.ijgo.2010.11.011.
- Leal CRV, Vannuccini S, Jain V, et al. Abnormal uterine bleeding: The well-known and the hidden face. J Endometr Uterine Disord. 2024 Jun:6:100071. DOI.org/10.1016/j.jeud.2024.100071.
- Demina TN, Goshkoderya IY. Luteal phase deficiency: new approaches to solving old problems. Women’s Health. 2004;34(20):63–9.
- Carp HJA, ed. Recurrent pregnancy loss: causes, controversies, and treatment. CRC press, 2014.
- Kouides PA, Conard J, Peyvandi F, et al. Hemostasis and menstruation: appropriate investigation for underlying disorders of hemostasis in women with excessive menstrual bleeding. Fertil Steril 2005;84:1345–51.
- Shamsi A, Cannata A, Piper S, et al. Treatment of iron deficiency in heart failure. Curr Cardiol Rep. 2023;25:649–61. DOI:10.1007/s11886-023-01889-4.
- Provenzano R, Lerma EV, Szczech L, eds. Management of Anemia: A Comprehensive Guide for Clinicians. Springer; 2018. DOI:10.1007/978-1-4939-7360-6.
- Sikka M, Kumar HB. Iron Metabolism and Iron Deficiency Anemia. Hematopathology. 2019:27–47. DOI: 10.1007/978-981-13-7713-6_2.
- Essam AEN, Sharif G, Al-Hameed F, et al. Venous thromboembolism-related mortality and morbidity in King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia. Ann. Thorac. Med. 2011 Oct;6(4):193–8. DOI: 10.4103/1817-1737.84772.
- Neeland IJ, Lim S, Tchernof A, et al. Metabolic syndrome. Nat Rev Dis Primers. 2024 Oct 17; 10(1):77. DOI: 10.1038/s41572-024-00563-5
- Lipsombe L, Booth G, Butalia S, et al. Diabetes Canada 2018 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada. Canadian Family Physician. 2019 Jan; 65(1): 14–24.
- ElSayed NA, Aleppo G, Aroda VR, et al. Introduction and Methodology: Standards of Care in Diabetes-2023. Diabetes Care. 2023 Jan 1; 46(Suppl 1): S1–S4. DOI: 10.2337/dc23-Sint.
- Jones K, Sung S. Anovulatory Bleeding. 2021 Jun 26. [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan. Available from: https://www.ncbi.nlm. nih.gov/books/NBK549773/
- Lockwood CJ. Mechanisms of normal and abnormal endometrial bleeding. Menopause. 2011 Apr;18(4):408–11. DOI: 10.1097/GME.0b013e31820bf288
- Stanczyk FZ, Hapgood JP, Winer S, Mishell DR Jr. Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects. Endocr Rev. 2013 Apr; 34(2): 171–208. DOI: 10.1210/er.2012-1008
- Schindler AE, Campagnoli C, Druckmann R, et al. Classification and pharmacology of progestins. Maturitas. 2003; 46 Suppl 1: S7–S16. DOI:10,1016/j.maturitas.2003.09.014.
- Rižner TL, Brožič P, Doucette C, et al. and potency of the retroprogesterone dydrogesterone in vitro. Steroids. 2011; 76(6): 607–15. DOI: 10,1016/j.steroids.2011.02.043.
- Schindler AE. Progestational effects of dydrogesterone in vitro, in vivo and on
- the human endometrium. Maturitas. 2009;65 Suppl 1: S3–S11. DOI:10,1016/j.maturitas.2009.10.011.
- Instructions for medical use of the drug Duphaston®. [Internet]. Available from: https://mozdocs.kiev.ua/likiview.php?id=15524
- Instructions for medical use of micronized progesterone (vaginal tablets 100 or 200 mg) [Internet]. Available from: https://likicontrol.com.ua/%D1%96%D0%BD%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%86%D1%9 6%D1%8F/?[28690]
- Instructions for medical use of the combination ethinylestradiol 0.03 mg/drospirenone 3 mg (film-coated tablets) [Internet]. Available from: https://likicontrol.com.ua/%D1%96%D0%BD%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%86%D1%9 6%D1%8F/?[42208]
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Т.Ф. Татарчук, О.В. Булавенко, Н.Ю. Педаченко, О.Л. Громова, Ю.О. Дубоссарська, Н.Ф. Захаренко, О.О. Єфіменко, Л.В. Калугіна, Н.В. Косей, Н.М. Рожковська, Т.М. Тутченко, В.І. Пирогова, О.Г. Яшина, Д.М. Свірський, І.О. Родіонова, Л.А. Луценко

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.