Management of abnormal uterine bleeding in the current realities

Authors

DOI:

https://doi.org/10.18370/2309-4117.2025.78.8-14

Keywords:

abnormal uterine bleeding, polycystic ovarian syndrome, phytotherapy, quality of life, psycho-emotional state

Abstract

Objective of the study: to optimize approaches to the treatment of abnormal uterine bleeding (AUB) in internally displaced women, considering its impact on patients’ quality of life, mental health, and daily activity.

Materials and methods. The study included 90 women aged 18–55 years diagnosed with AUB. The patients were divided into three groups of 30 people, who received different treatments for 3 months during menstruation and bloody discharge: group I took a herbal hemostatic complex (Foxygen); group II took a hemostatic complex in combination with a preparation of Vitex agnus castus extract Ze440 20 mg (Prefemin); group III (control) took a tranexamic acid 500 mg three times a day. The effectiveness of therapy was assessed using the SF-36 scale for quality of life evaluation, the SAN scale for assessing well-being, activity, and mood, as well as by measuring the duration and volume of blood loss.

Results. After three months of therapy, all groups showed a significant reduction in the duration and intensity of bleeding (p < 0.05). The best results were observed in group II, where the mean duration of bleeding decreased to 5.1 ± 0.7 days, and the menstrual blood loss volume decreased to 61.2 ± 7.4 ml. In group III, these values were 5.0 ± 0.8 days and 57.5 ± 6.1 ml, respectively. Quality of life improvements on the SF-36 scale were most pronounced in group II, particularly in general health perception, social functioning, and mental health. The SAN scale demonstrated significant improvements in well-being and mood, especially in groups II and III.

Conclusions. The combined use of herbal preparations is an effective and safe alternative to standard AUB therapies in women. This therapy not only supports hemostasis but also positively influences the patients’ psycho-emotional state, making it a crucial component of comprehensive AUB management in stressful conditions.

Author Biographies

T.F. Tatarchuk, SI «All-Ukrainian Centre for Motherhood and Childhood of the NAMS of Ukraine»; SSI “Center for Innovative Medical Technologies of the NAS of Ukraine», Kyiv

MD, professor, corresponding member of the NAMS of Ukraine, deputy director for research work, head of the Endocrine Gynecology Department;
chief researcher of the Department of Reproductive Health

N.V. Kosei, SI “All-Ukrainian Center for Maternity and Childhood of the NAMS of Ukraine”, Kyiv

MD, professor, chief researcher, Endocrine Gynecology Department

N.F. Zakharenko, SI «All-Ukrainian Centre for Motherhood and Childhood of the NAMS of Ukraine»; Clinic «Institute of Family Planning», Kyiv

MD, professor, leading researcher, Endocrine Gynecology Department;
head of the scientific board

T.M. Tutchenko, SI “All-Ukrainian Center for Maternity and Childhood of the NAMS of Ukraine”; SI «Center for Innovative Medical Technologies of the NAS of Ukraine», Kyiv

PhD, senior researcher, Endocrine Gynecology Department;
Department of Reproductive Health

O.G. Parkhometnko, SI “All-Ukrainian Center for Maternity and Childhood of the NAMS of Ukraine”, Kyiv

junior researcher, Endocrine Gynecology Department

T.E. Krysenko, SI “All-Ukrainian Center for Maternity and Childhood of the NAMS of Ukraine”, Kyiv

postgraduate student, Endocrine Gynecology Department

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Published

2025-06-20

How to Cite

Tatarchuk, T., Kosei, N., Zakharenko, N., Tutchenko, T., Parkhometnko, O., & Krysenko, T. (2025). Management of abnormal uterine bleeding in the current realities. REPRODUCTIVE ENDOCRINOLOGY, (78), 8–14. https://doi.org/10.18370/2309-4117.2025.78.8-14

Issue

No. 78 (2025)

Section

Gynecology

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Copyright (c) 2025 Т.Ф. Татарчук, Н.В. Косей, Н.Ф. Захаренко, Т.М. Тутченко, О.Г. Пархоменко, Т.Е. Крисенко

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