Short cervix: modern perspectives on known problems
DOI:
https://doi.org/10.18370/2309-4117.2024.73.22-28Keywords:
short cervix, isthmic-cervical insufficiency, reproductive losses, wartime, micronized vaginal progesterone, cerclage, pessaries, polyunsaturated fatty acids, vitamins, magnesiumAbstract
The article provides modern literature data on terminology, diagnostics and new approaches to the treatment of short cervix syndrome. The term «short cervix» combines the concept of short cervix and isthmic-cervical insufficiency in most of the guiding documents of the world obstetrics and gynecology societies. However, the issues of diagnosis and correction of these conditions remain relevant and debatable: sonographic criteria, the use of progesterone, cerclage, obstetric pessaries, their various combinations, and the question of their effectiveness.
It is necessary to measure the cervix length by transvaginal cervicometry in the 20 weeks of pregnancy in the absence of previous reproductive losses and in the period of 14–16 weeks if there were previous reproductive losses. Therapeutic interventions should be started (vaginal micronized progesterone, cerclage, obstetric pessary) when the cervix is shortened to 25 mm or less at 20 weeks. Urgent cerclage should be performed when the umbilical cord is shortened to 20 mm or less. The effectiveness of cerclage, according to most experts, is comparable to the effectiveness of vaginal progesterone, unlike obstetric pessaries, the effectiveness of which is currently considered unproven.
For our country today, in addition to the generally recognized risk factors of this pathology, the factors associated with improper conditions for providing medical care and their consequences are especially relevant. Childbirth in inappropriate places without observing the rules of asepsis and antiseptics, often without qualified medical personnel, can lead to undiagnosed and lack of suturing of cervical tears), their infection, subsequent deformation and functional failure of the cervix.
There is also a need to support the micronutrient status of pregnant women in wartime conditions in Ukraine (vitamins of group B, vitamin D, magnesium, polyunsaturated fatty acids) in combination with progestins (micronized progesterone Luteinа) and/or cerclage in case of short cervix.
References
- Kay C. Short cervix: During pregnancy and causes [Interhet]. MedicalNewsToday. 2020. Available from: https://www.medicalnewstoday.com/articles/short-cervix
- BerghellaV, SimpsonLL, Barss VA. Short cervix before 24 weeks: Screening and management in singleton pregnancies. [Interhet]. Available from: https://www.uptodate.com/contents/short-cervix-before-24-weeksscreening-and-management-in-singleton-pregnancies/print
- Romero R, Conde-Agudelo A, Da Fonseca E, et al. Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data. Am J Obstet Gynecol. 2018 Feb;218(2):161–180. DOI: 10.1016/j.ajog.2017.11.576.
- Romero, R, Conde-Agudelo, A, Rehal, A, et al. Vaginal progesterone for the prevention of preterm birth and adverse perinatal outcomes in twin gestations with a short cervix: an updated individual patient data meta-analysis. Ultrasound Obstet Gynecol. 2022 Feb;59(2):263–266. DOI: 10.1002/uog.24839
- Simhan HN, Bryant А, Gandhi M. Updated Clinical Guidance for the Use of Progesterone Supplementation for the Prevention of Recurrent Preterm Birth. [Interhet]. ACOG. 2023 Apr. Available from: https://www.acog.org/clinical/clinical-guidance/practice%20advisory/articles/2023/04/updated-guidance-use-of-progesteronesupplementation-for-prevention-of-recurrent-preterm-birth
- Ectopic pregnancy and miscarriage: diagnosis and initial management. [Interhet]. NICE guideline [NG126]. 17 April, 2019 Available from: https://www.nice.org.uk/guidance/ng126
- Regan L, Rai R, Saravelos S, Li T.-Ch. Recurrent Miscarriage Green-top Guideline No. 17. BJOG. 2023 Nov;130(12):e9–e39. DOI: 10.1111/1471-0528.17515
- Shehata H, Elfituri A, Doumouchtsis SK, et al. FIGO Good Practice Recommendations on the use of progesterone in the management of recurrent first-trimester miscarriage. Int J Gynaecol Obstet. 2023 Apr:161 Suppl 1:3–16. DOI: 10.1002/ijgo.14717
- Conde-Agudelo A, Romero R. Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and metaanalysis. Am J Obstet Gynecol. 2022 Sep;227(3):440–61.e2. DOI: 10.1016/j.ajog.2022.04.023.
- Dijk CE, Gils AL, Koullali B. Cervical pessary versus vaginal progesterone in women with a singleton pregnancy, a short cervix, and no history of spontaneous preterm birth at less than 34 weeks’ gestation: open label, multicentre, randomised, controlled trial. BMJ. 2024 Mar 12:384:e077033. DOI: 10.1136/bmj-2023-077033
- Hoffman, M.K, Clifton, R.G, Biggio, J.R, et al. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network. Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix: The TOPS Randomized Clinical Trial. JAMA. 2023 Jul 25;330(4):340–8. DOI: 10.1001/jama.2023.10812.
- Kornete A, Volozonoka L, Zolovs M, et al. Management of Pregnancy with Cervical Shortening:Real-Life Clinical Challenges.Medicina (Kaunas). 2023 Mar 26;59(4):653. DOI: 10.3390/medicina59040653.
- Coutinho, C.M, Sotiriadis A, Odibo A, et al. ISUOG Practice Guidelines: role of ultrasound in the prediction of spontaneous preterm birth. Ultrasound Obstet Gynecol. 2022. Sep;60(3):435–56. DOI: 10.1002/uog.26020.
- Shennan A, Story L, Jacobsson B, Grobman WA, FIGO Working Group for Preterm Birth. FIGO good practice recommendations on cervical cerclage for prevention of preterm birth.Int J Gynaecol Obstet. 2021. Oct;155(1):19–22. DOI: 10.1002/ijgo.13835.
- Grobman W.A, Norman J, Jacobsson B, FIGO Working Group for Preterm Birth. FIGO good practice recommendations on the use of pessary for reducing the frequency and improving outcomes of preterm birth. Int J Gynaecol Obstet. 2021. Oct;155(1):23–5. DOI: 10.1002/ijgo.13837.
- Goya M, Pratcorona L, Merced C, Rodó C, et al. Pesario Cervical para Evitar Prematuridad (PECEP) Trial Group. Cervical pessary in pregnant women with a short cervix (PECEP): an open-label randomised controlled trial. Lancet. 2012 May 12;379(9828):1800–6. DOI: 10.1016/S0140-6736(12)60030-0.
- Menichini D, Imbrogno M.G, Basile L, et al. Author Correction: Oral supplementation of α-lipoic acid (ALA), magnesium, vitamin B6 and vitamin D stabilizes cervical changes in women presenting risk factors for preterm birth. Eur Rev Med Pharmacol Sci. 2023 Jan 27(1):1. DOI: 10.26355/eurrev_202301_30843.
- Shabani A, Abiri A, Ghalandarpoor-Attar S.N, et al. Could Maternal Vitamin D Concentration Affect Cervical Length in Mid-Pregnancy? A Report From an Iranian Tertiary Center. J Family Reprod Health. 2022 Dec 16(4):290–295. DOI: 10.18502/jfrh. v16i4.11360.
- Kar S, Wong M, Rogozinska E, Thangaratinam Sh, et al. Effects of omega-3 fatty acids in prevention of early preterm delivery: a systematic review and meta-analysis of randomized studies. Eur J Obstet Gynecol Reprod Biol. 2016 Mar:198:40–46. DOI: 10.1016/j.ejogrb.2015.11.033
- Klein A. Omega-3 supplements could reduce the number of premature births [Interhet]. New Scientist. 2022. Available from: https://www.newscientist.com/article/2309696-omega-3-supplements-could-reduce-the-number-of-premature-births
- Savona-Ventura Ch, Mahmood T, Mukhopadhyay S. Omega-3 fatty acid supply in pregnancy for risk reduction of preterm and early preterm birth: A position statement by the European Board and College of Obstetrics and Gynaecology (EBCOG). Eur J Obstet Gynecol Reprod Biol. 2024 Apr:295:124–125. DOI: 10.1016/j.ejogrb.2024.02.009
- Benuk V.O, Korniets N.G, Oleshko, V.F. Obstetric tactics at isthmicocervical insufficiency Health of woman. 2018;9(135):10–14. DOI: 10.15574/HW.2018.135.10
- Shcherbina M. O, Lipko O. P, Shcherbina I. M. New approaches in prevention of unfavourable peritoneal outcomes in women with miscarriage Actual issues of pediatrics, obstetrics and gynecology. 2019;1. DOI: 10.11603/24116–4944.2019.1.10205
- Ismailov R. I. Innovative approaches to the treatment ofrecurrent pregnancy lossin isthmic-cervical insufficiency by applying an intracorporeal suture: dissertation....doctor of philosophy: 14.01.01.- [Interhet]. Kiyv. 2023;203p. Available from: https://www.nuozu.edu.ua/zagruzka3/Dr_Ismailov.pdf
- Oleshko VF. Prevention of obstetric and perinatal complications in pregnant women with insufficiency of the obturation function of the cervix: dissertation....Candidate of Medical Sciences: 14.01.01. [Interhet]. Kyiv. 2017; 235p. Available from: https://ipag-kiev.org.ua/wp-content/uploads/2017/05/Aref-1.pdf
- Zhabchenko, I.А. Isthmic-cervical insufficiency: classification, etiopathogenesis, diagnosis Academic lectures on obstetrics and gynecology. A collection of lectures edited by Acad. Antipkin, Y.G, Kyiv: KRIEYTIV MEDIA LLC, 2023:205–221.
- Kolesnik N.M. Optimization of treatment of isthmic-cervical insufficiency: autoref. dis....Candidate of Medical Sciences: 14.01.01. Kyiv, 2017:22 p.
- Rajabi-Naeeni M, Dolatian M, Qorbani M, et al. Effect of omega-3 and vitamin D co-supplementation on psychological distress in reproductive-aged women with prediabetes and hypovitaminosis D: A randomized controlled trial. Brain Behav. 2021 Nov;11(11):e2342. DOI: 10.1002/brb3.2342.
- Madison A, Belury M, Andridge R.R, et al. Omega-3 supplementation and stress reactivity of cellular aging biomarkers: an ancillary substudy of a randomized, controlled trial in midlife adults. Mol Psychiatry 2021;26, 3034–42. DOI: 10.1038/s41380-021-01077-2.
- DeLuca G.C, Kimball S.M, Kolasinski J, et al. Review: the role of vitamin D in nervous system health and disease. Neuropathol Appl Neurobiol. 2013 Aug;39(5):458–84. DOI: 10.1111/nan.12020
- Sultan S, Taimuri U, Basnan Sh. A, et al. Low Vitamin D and Its Association with Cognitive Impairment and Dementia. J Aging Res. 2020 Apr 30;2020:6097820. DOI: 10.1155/2020/6097820.
- Lysy J, Rybolsy M, Siracuzano A. et al. Maternal vitamin D and its role in determining the origin of fetal mental health. Curr Pharm Des. 2020;26(21):2497–509. DOI: 10.2174/1381612826666200506093858
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.