The effect of vitamin D and magnesium deficiency on the course of adenomyosis in the post covid-19 period in women of reproductive age

Authors

DOI:

https://doi.org/10.18370/2309-4117.2024.72.23-27

Keywords:

adenomyosis, COVID-19, vitamin D, trace element magnesium, pain, dyspareunia

Abstract

Objective of the study: to investigate the content of vitamin D and the trace element magnesium in the blood of women of reproductive age with adenomyosis of the I–II and III–IV degrees after the COVID-19 disease depending on the algorithm of their management at 3, 6 and 12 months, as well as assess the general condition of patients.
Materials and methods. 150 women after the COVID-19 disease were under observation: 30 practically healthy women (control group A), 60 patients with adenomyosis of the I–II degree (group B) and 60 patients with adenomyosis of the III–IV degree (group C). Observation continued for 3, 6 and 12 months after the COVID-19 disease.
Results. Deterioration of well-being in patients with adenomyosis in the first months after COVID-19 has been proven. The frequency of complaints increased significantly: lethargy (55.0%), headache (36.7%), joint pain (41.7%), muscle pain (40.8%), pelvic pain (38.3%), dyspareunia (100%), etc. According to the scale of verbal assessment of pelvic pain, moderate pain (2 points) was experienced by 30.0% of patients of group B and 43.3% in group C, at the same time, severe (3 points) – 33.3%, very strong
(4 points) – 20.0%.
A significant decrease in the level of vitamin D and Mg was detected in women after the COVID-19 disease (p < 0.05): in almost all healthy women (group A) and in patients with adenomyosis (groups B and C). A significantly lower content of vitamin D and Mg was found in groups B and C compared to group A (p < 0.05), and in group C compared to group B.
The effectiveness of taking vitamin D and magnesium preparations in patients with adenomyosis after the COVID-19 disease was confirmed: a significant difference in the frequency of symptoms characterizing the general condition of patients after 3, 6 and 12 months was obtained: a decrease in the frequency of neuroses, headaches, muscle pain, constant lower abdominal pain, dyspareunia, etc.
Conclusions. The effectiveness of taking vitamin D and magnesium preparations by women with adenomyosis after the COVID-19 disease has been confirmed.

Author Biographies

M.B. Zaporozhchenko, Odesa National Medical University, Odesa

MD, professor, Department of Obstetrics and Gynecology

A.V. Bulhar, Odesa National Medical University, Odesa

postgraduate student, Department of Obstetrics and Gynecology

G.F. Stepanov, Odessa National Medical University, Odesa

MD, associate professor, head of the Department of Medical Biology and Chemistry

References

  1. Anghel L, Manole C, Nechita A, et al. Calcium, Phosphorus and Magnesium Abnormalities Associated with COVID-19 Infection, and Beyond. Biomedicines 2023 Aug 23;11(9):2362. DOI: 10.3390/biomedicines11092362
  2. Trapani V, Rosanoff A, Baniasadi S, et al. The relevance of magnesium homeostasis in COVID-19. Eur J Nutr. 2022;61(2):625–636. DOI:10.1007/s00394-021-02704-y
  3. Guerrero-Romero F; Micke O, Simental-Mendía LE, et al. Importance of Magnesium Status in COVID-19. Biology. 2023 May 18;12(5):735. DOI: 10.3390/biology12050735
  4. Rawji A, Peltier MR, Mourtzanakis K, et al. Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review. Cureus. 2024;16(4):e59317. DOI:10.7759/cureus.59317
  5. Arancibia-Hernández YL, Aranda-Rivera AK, Cruz-Gregorio A, Pedraza-Chaverri J. Antioxidant/anti-inflammatory effect of Mg2+ in coronavirus disease 2019 (COVID-19). Rev Med Virol. 2022 Sep;;32(5):e2348. DOI:10.1002/rmv.2348
  6. Ma H, Hong M, Duan J, et al. Altered cytokine gene expression in peripheral blood monocytes across the menstrual cecle in primary dysmenorrhea: a case–control study. PloSOne. 2013;8(2): e55200. DOI: 10.1371/journal.pone.0055200
  7. Maybin JA, Murray AA, Saunders PTK, et al. Hypoxia and hypoxia inducible factor–1 alpha are reguired for normal endomentrial repair during menstruation. Nat. Commun. 2018. Jan 23;9(1):295. DOI: 10.1038/s41467-017-02375-6
  8. Batiha GE, Al-Gareeb AI, Qusti S, et al. Deciphering the immunoboosting potential of macro and micronutrients in COVID support therapy. Environ Sci Pollut Res Int. 2022;29(29):43516–43531. DOI:10.1007/s11356-022-20075-7
  9. Vannuccini S. Luisi S,. Tosti C, et al. Role of medical therapy in the management of uterine adenomyosis. Fertil Steril. 2018 Mar;109(3):398–405. DOI: 10.1016/j.fertnstert.2018.01.013.
  10. Karlsson WK, Sorensen CG, Kruuse C. L–arginine and I–NMMA for assessing cerebral endothelial dysfunction in ischaemic cerebrovascular diease: Asystematic review. Clin Exp Pharmacol Physiol. 2017 Jan;44(1):13–20. DOI: 10.1111/1440-1681.12679.
  11. Cenacchi V, Maier JA, Perini MP. A potential protective role of magnesium in neuroCOVID. A potential protective role of magnesium in neuroCOVID. Magnes Res. 2022;35(1):18–26. DOI:10.1684/mrh.2022.0497
  12. Noris M, Benigni A, Remuzzi G. The case of complement activation in COVID-19 multiorgan impact. Kidney Int. 2020;98(2):314–322. DOI:10.1016/j.kint.2020.05.013
  13. Ladds E, Rushforth A, Wieringa S, et al. Persistent symptoms after COVID–19: qualitative study of 114 «long COVID» patients and draft quality criteria for services. BMC Health Services Research. 2020. Dec 20;20(1):1144. DOI: 10.1186/s12913–020–06001–y
  14. Quilliot D, Bonsack O, Jaussaud R, Mazur A. Dysmagnesemia in Covid-19 cohort patients: prevalence and associated factors. Magnes Res. 2020;33(4):114–122. DOI:10.1684/mrh.2021.0476
  15. da Silva SR, Ju E, Meng W, et al. Broad SARS–Cov–2 cell tropism and immunopathology in lung tissues from fatal COVID-19. [Internet]. MedRxiv. 2020 Sep. Available from: https://www.medrxiv.org/content/10.1101/2020.09.25.2019 5818v1. DOI:10.1101/2020.09.25.20195818.
  16. Margo O, Mulvey JJ, BerlinD. Complement associated microvascular injury, and thrombosis in the pathogenesis of severe COVID–19 infection: A repert of five cases. Transl Res. 2020 Jun:220:1–13. DOI: 10.1016/j.trsl.2020.04.007.
  17. Thurber KM, Otto AO, Stricker SL. Proton pump inhibitors: Understanding the associated risks and benefits of long-term use. Am J Health Syst Pharm. 2023 Apr 8;80(8):487–94. DOI: 10.1093/ajhp/zxad009
  18. Brodin P. Immune determinants of COVID–19 disease presentation and severity. Nat Med. 2021. Jan;27(1):28-33. DOI: 10.1038/s41591-020-01202-8
  19. Pereira M, Dantas Damascena A, Galvao Azevedo LM, et al. Vitamin D deficiency aggra vates COVID–19: systematic review and meta–analysis. Crit Rev Food Sci Nutr. 2022;62(5):1308–16. DOI:10.1080/10408398.2020.1841090
  20. Chiodini I,. Gatti D, Soranna D, et al. Vitamin D status and SARS–CoV–2 infection and COVID–19 clinical outcomes. Front Public Health. 2021 Dec 22:9:736665. DOI: 10.3389/fpubh.2021.736665
  21. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta–analysis of individual participant data. BMG. 2017 Feb 15:356:i6583. DOI:10.1136/bmj.i6583
  22. Stratopoulou CA, Donnez J, Dolmans MM. Origin and Pathogenic Mechanisms of Uterine Adenomyosis: What Is Known So Far. Reprod Sci. 2021. Aug;28(8):2087–97. DOI: 10.1007/s43032-020-00361-w
  23. Weidinger C, Hegazy AN, Glauben R, Siegmund B. COVID-19-from mucosal immunology to IBD patients. Mucosal Immunol. 2021. May;14(3):566–573. DOI: 10.1038/s41385–021–00384
  24. Temporary guidelines. Prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Version 6 [Internet]. 2020 4 Apr. Available from: https://static–1.rosminzdrav.ru/system/attachments/attaches/000/050/122/ original / 28042020_% D0% 9CR_COVID–19_v6.pdf
  25. Coronavirus infection and pregnancy FAQs. [Internet]. Royal College of Obstetricians and Gynaecologists. 2023. Available from: https://www.rcog.org.uk/en/guidelines–research–services/guidelines/coronavirus–pregnancy/covid–19–virus–infection–and–pregnancy.

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Published

2024-06-30

How to Cite

Zaporozhchenko, M., Bulhar, A., & Stepanov, G. (2024). The effect of vitamin D and magnesium deficiency on the course of adenomyosis in the post covid-19 period in women of reproductive age. REPRODUCTIVE ENDOCRINOLOGY, (72), 23–27. https://doi.org/10.18370/2309-4117.2024.72.23-27

Issue

No. 72 (2024)

Section

Gynecology

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