Role of oxidative stress in genesis of endometriosis

Authors

  • Н. Ф. Захаренко Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine, Ukraine
  • Т. Ф. Татарчук Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine, Ukraine
  • Н. В. Коваленко Clinical City Hospital number 9, Kiev, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2014.18.13-16

Keywords:

endometriosis, oxidative stress, lipid peroxidation, ferric iron, Maltofer

Abstract

A comparison of frequencies of allelic variants of genes GSTM1, GSTT1, CYP2D6 in women with endometriosis (139 women) and healthy women (192 women in the control group) was made, and the state of lipid peroxidation in women studied groups was study.
The results showed that activity of lipid peroxidation higher in women with endometriosis, regardless of the site of endometriotic lesions, compared with the control group of healthy women. This demonstrates the importance of oxidative stress in the endometriosis formation.
Also, the results of research suggest that one way of leveling oxidative stress in women with endometriosis can be used of ferric drugs (Maltofer), due to the peculiarities of their digestion and minimize the risk of oxidative stress worsening.

Author Biographies

Н. Ф. Захаренко, Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine

MD, chief researcher at the Endocrine Gynecology Department

Т. Ф. Татарчук, Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine

MD, professor, corresponding member of the NAMS of Ukraine, Deputy Director for Research Work, Head of the Endocrine Gynecology Department

Н. В. Коваленко, Clinical City Hospital number 9, Kiev

Doctor of the Gynecological Department

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Published

2014-11-17

How to Cite

Захаренко, Н. Ф., Татарчук, Т. Ф., & Коваленко, Н. В. (2014). Role of oxidative stress in genesis of endometriosis. REPRODUCTIVE ENDOCRINOLOGY, (18), 13–16. https://doi.org/10.18370/2309-4117.2014.18.13-16

Issue

No. 18 (2014)

Section

Scientific Studies

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Copyright (c) 2014 Н. Ф. Захаренко, Т. Ф. Татарчук, Н. В. Коваленко

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