Metafolin in combined oral contraceptives – investments in reproductive welfare. World news: modern contraception – opportunity of pregravidarum preparing
DOI:
https://doi.org/10.18370/2309-4117.2013.11.82-88Keywords:
folic acid, combined oral contraceptives, pregnancy, MetafolinAbstract
This article is a review of the material on the key studies that demonstrated in women of reproductive age, especially considering pregnancy the efficacy and safety of oral contraceptives containing ethinylestradiol and drospirenone combined with the active form of folic acid. Such combination provide increased folate levels in red blood cells and in plasma, reduced homocysteine levels in the blood plasma, thereby significantly reduce the probability of abnormal fetus development. The expediency of receiving data combined drugs proved not only for contraception, but also for pregravidarum preparing – to normalize the folate status of women requires minimum 16 weeks of exogenous folate intake, and the probability of pregnancy is very high right after the withdrawal combined oral contraceptives.References
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