Clinical and pathogenetic parallels of the hormonal profile and the qualitative composition of the intestinal microbiocenosis in pregnant women




pregnancy, metabolic syndrome, obesity, intestinal microbiocenosis, hormonal profil


Objective of the study: assessment of clinical and pathogenetic parallels of changes in the hormonal profile and qualitative composition of intestinal microbiocenosis in pregnant women with different nutritional status at different stages of gestation.

Materials and methods. 96 pregnant women aged 25–35 with metabolic syndrome (group I), 37 women with obesity of the first degree (group II) and 30 women of the same age with normotrophic nutritional status and physiological course of pregnancy (control group) were examined. Average blood pressure was monitored, the hormonal profile (progesterone, estriol, leptin levels) and lipid profile was assessed, as well as the composition of the intestinal microbiocenosis at 17–20 and 35–37 weeks of gestation.

Results. In the period of 17–20 weeks the leptin level in the I group was 38.4 ± 0.7 μg/ml, in the II group – 37.7 ± 1.1 μg/ml, in the control group – 33.2 ± 1.3 μg/ml. In the period of 35–37 weeks its level decreased in all clinical groups, amounting to 112.7 ± 1.4 μg/ml in the I group, 118.3 ± 3.9 μg/ml in the II group, 237 5 ± 5.3 μg/ml in the control group.

Cases of the II degree of intestinal dysbiosis prevailed in groups I and II. 65 cases of I degree of dysbiosis and 32 cases of the II degree were found in the I group, 27 and 10 cases in the II group, respectively. 4 (13.3%) pregnant women had II degree of dysbiosis, 12 (40.0%) had I degree of dysbiosis in the control group. The frequency of dysbiosis was correlated with the body mass index (r = 0.82 p < 0.05), the blood content of estradiol (r = 0.49 p < 0.05), progesterone (r = -0.34 p < 0, 05) and leptin (r = 0.69 p < 0.05).

Conclusions. The presence of metabolic syndrome and obesity in pregnant women affects the qualitative composition of the intestinal microbiocenosis, which is manifested by an increase in the population of opportunistic microorganisms. The frequency of dysbiosis correlates with the body mass index, estradiol, progesterone and leptin concentrations.

Author Biographies

V.G. Marichereda, Odesa National Medical University, Odesa

MD, professor, Department of Obstetrics and Gynecology

I.O. Adonina, Odessa National Medical University, Odesa, Ukraine

Department of Obstetrics and Gynecology

N.M. Rozhkovska, Odesa National Medical University, Odesa

MD, professor, Obstetrics and Gynecology Department


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How to Cite

Marichereda, V., Adonina, I., & Rozhkovska, N. (2024). Clinical and pathogenetic parallels of the hormonal profile and the qualitative composition of the intestinal microbiocenosis in pregnant women. REPRODUCTIVE ENDOCRINOLOGY, (71), 67–71.



Pregnancy and childbirth