Clinical and pathogenetic parallels of the hormonal profile and the qualitative composition of the intestinal microbiocenosis in pregnant women

Authors

DOI:

https://doi.org/10.18370/2309-4117.2024.71.67-71

Keywords:

pregnancy, metabolic syndrome, obesity, intestinal microbiocenosis, hormonal profil

Abstract

Objective of the study: assessment of clinical and pathogenetic parallels of changes in the hormonal profile and qualitative composition of intestinal microbiocenosis in pregnant women with different nutritional status at different stages of gestation.

Materials and methods. 96 pregnant women aged 25–35 with metabolic syndrome (group I), 37 women with obesity of the first degree (group II) and 30 women of the same age with normotrophic nutritional status and physiological course of pregnancy (control group) were examined. Average blood pressure was monitored, the hormonal profile (progesterone, estriol, leptin levels) and lipid profile was assessed, as well as the composition of the intestinal microbiocenosis at 17–20 and 35–37 weeks of gestation.

Results. In the period of 17–20 weeks the leptin level in the I group was 38.4 ± 0.7 μg/ml, in the II group – 37.7 ± 1.1 μg/ml, in the control group – 33.2 ± 1.3 μg/ml. In the period of 35–37 weeks its level decreased in all clinical groups, amounting to 112.7 ± 1.4 μg/ml in the I group, 118.3 ± 3.9 μg/ml in the II group, 237 5 ± 5.3 μg/ml in the control group.

Cases of the II degree of intestinal dysbiosis prevailed in groups I and II. 65 cases of I degree of dysbiosis and 32 cases of the II degree were found in the I group, 27 and 10 cases in the II group, respectively. 4 (13.3%) pregnant women had II degree of dysbiosis, 12 (40.0%) had I degree of dysbiosis in the control group. The frequency of dysbiosis was correlated with the body mass index (r = 0.82 p < 0.05), the blood content of estradiol (r = 0.49 p < 0.05), progesterone (r = -0.34 p < 0, 05) and leptin (r = 0.69 p < 0.05).

Conclusions. The presence of metabolic syndrome and obesity in pregnant women affects the qualitative composition of the intestinal microbiocenosis, which is manifested by an increase in the population of opportunistic microorganisms. The frequency of dysbiosis correlates with the body mass index, estradiol, progesterone and leptin concentrations.

Author Biographies

V.G. Marichereda, Odesa National Medical University, Odesa

MD, professor, Department of Obstetrics and Gynecology

I.O. Adonina, Odessa National Medical University, Odesa, Ukraine

Department of Obstetrics and Gynecology

N.M. Rozhkovska, Odesa National Medical University, Odesa

MD, professor, Obstetrics and Gynecology Department

References

  1. Seneviratne SN, Rajindrajith S. Fetal programming of obesity and type 2 diabetes. World J Diabetes. 2022 Jul 15;13(7):482–97. DOI: 10.4239/wjd.v13.i7.482
  2. Harary D, Akinyemi A, Charron MJ, Fuloria M. Fetal Growth and Intrauterine Epigenetic Programming of Obesity and Cardiometabolic Disease. Neoreviews. 2022 Jun 1;23(6):e363–e372. DOI: 10.1542/neo.23-6-e363
  3. Catalano PM, Shankar K. Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child. BMJ. 2017 Feb 8;356:j1. DOI: 10.1136/bmj.j1
  4. Corrales P, Vidal-Puig A, Medina-Gómez G. Obesity and pregnancy, the perfect metabolic storm. Eur J Clin Nutr. 2021 Dec;75(12):1723–34. DOI: 10.1038/s41430-021-00914-5.
  5. Lima RA, Desoye G, Simmons D, et al. The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity. Paediatr Perinat Epidemiol. 2021 Jan;35(1):83–91. DOI: 10.1111/ppe.12682.
  6. Noyola-Martínez N, Halhali A, Barrera D. Steroid hormones and pregnancy. Gynecol Endocrinol. 2019 May;35(5):376–84. DOI: 10.1080/09513590.2018.1564742
  7. Ziętek M, Celewicz Z, Szczuko M. Short-Chain Fatty Acids, Maternal Microbiota and Metabolism in Pregnancy. Nutrients. 2021 Apr 9;13(4):1244. DOI: 10.3390/nu13041244.
  8. Szczuko M, Kikut J, Maciejewska D, et al. The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women. Int J Mol Sci. 2020 Dec 3;21(23):9212. DOI: 10.3390/ijms21239212
  9. Pavlovska OM, Pavlovska KM, Heryak SM, et al. Intestinal Dysbiosis As a Possible Predictor of Very Early Preterm Labor in Pregnant Women With Metabolic Syndrome. J Med Life. 2020 Apr-Jun;13(2):200–5. DOI: 10.25122/jml-2020-0027
  10. Order of the Ministry of Health of Ukraine No. 1437 of 08/09/2022 Standards of medical care «Normal pregnancy». [Internet]. Kyiv: Ministry of Health of Ukraine, 2022. Available from: https://www.dec.gov.ua/wp-content/uploads/2022/08/2022_1437_smd_nv.pdf
  11. Order of the Ministry of Health of Ukraine No. 427 dated 03.03.2023 Standards of medical care «Obesity in adults». [Internet]. Kyiv: Ministry of Health of Ukraine, 2023. Available from: https://www.dec.gov.ua/wpcontent/uploads/2023/03/smd_427_03032023.pdf
  12. American College of Obstetricians and Gynecologists. Obesity in Pregnancy. Practice Bulletin [Internet]. 2012 Jun;230. Available from: https://www.acog.org/clinical/ clinical-guidance/practice-bulletin/articles/2021/06/ obesity-in-pregnancy
  13. Mean Arterial Pressure (MAP). [Internet]. Available from: https://www.mdcalc.com/calc/74/ mean-arterial-pressure-map
  14. Enzyme Immunoassay for the Quantitative Determination of Progesterone Concentration in Human Serum or Plasma. [Internet]. Available from: https://www.linear.es/wpcontent/uploads/2018/03/6107620-PROGESTERONEEIA-.pdf
  15. Human Leptin Instant ELISA Kit. [Internet]. 2019. Available from: http://www.nwbiotec.com/index.php?g=asset&m=download&a=dw&smurl=8518
  16. Fotherby K. Hormones in normal and abnormal human tissues. New York: de Gruyter; 2019. 563 p.
  17. Lapovets LE, Lebed GB, Yastremska OO, et al, editors. Clinical laboratory diagnostics: textbook. Lviv, 2023. 472 p.
  18. Haller D, editor. The Gut Microbiome in Health and Disease. [Internet]. NY, 2018 356 p. Available from: https://doi.org/10.1007/978-3-319-90545-7
  19. Schwiertz A, editor Microbiota of the Human Body. [Internet]. Advances in Experimental Medicine and Biology, vol 902. Springer, Cham. 2016. Available from: https://doi.org/10.1007/978-3-319-31248-4_5
  20. Marano G, Traversi G, Gaetani E, et al. Gut microbiota in women: The secret of psychological and physical well-being. World J Gastroenterol. 2023 Dec 7;29(45):5945-5952. DOI: 10.3748/wjg.v29.i45.5945.
  21. Fins JJ. Bioethics, Ukraine, and the Peril of Silence. Cambridge Quarterly of Healthcare Ethics. 2023;32(1):1-3. DOI:10.1017/S0963180122000238
  22. Fetisov VS, editor. Package of statistical data analysis STATISTICA: training. Manual. Nizhin: NSU named after M. Gogolб 2018. 114 с.
  23. Portincasa P, Bonfrate L, Vacca M, et al. Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis. Int J Mol Sci. 2022 Jan 20;23(3):1105. DOI: 10.3390/ijms23031105.
  24. Rasouli-Saravani A, Jahankhani K, Moradi S, et al. Role of microbiota short-chain fatty acids in the pathogenesis of autoimmune diseases. Biomed Pharmacother. 2023 Jun;162:114620. DOI: 10.1016/j.biopha.2023.114620.
  25. Ratajczak W, Rył A, Mizerski A, et al. Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs). Acta Biochim Pol. 2019 Mar 4;66(1):1–12. DOI: 10.18388/abp.2018_2648.

Downloads

Published

2024-03-15

How to Cite

Marichereda, V., Adonina, I., & Rozhkovska, N. (2024). Clinical and pathogenetic parallels of the hormonal profile and the qualitative composition of the intestinal microbiocenosis in pregnant women. REPRODUCTIVE ENDOCRINOLOGY, (71), 67–71. https://doi.org/10.18370/2309-4117.2024.71.67-71

Issue

No. 71 (2024)

Section

Pregnancy and childbirth

License

Copyright (c) 2024 В.Г. Марічереда, І.О. Адоніна, Н.М. Рожковська

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.