Dynamics of C-reactive protein and albumin levels in women of late reproductive age during pregnancy induced in assisted reproductive technology programs

Authors

DOI:

https://doi.org/10.18370/2309-4117.2024.71.58-66

Keywords:

infertility, assisted reproductive technologies, induced pregnancy, late reproductive age, C-reactive protein, albumin

Abstract

Background. Pregnancy from a biological point of view is an inflammatory condition. Decreased fertility, especially when assisted reproductive technologies are required, as well as women’s late reproductive age is associated with increased inflammation.

Objective of the study: to determine the serum levels of C-reactive protein (CRP) and albumin in women of late reproductive age in the dynamics of pregnancy induced in assisted reproductive technologies programs.

Materials and methods. Under observation were 123 women with infertility cured in assisted reproductive technologies cycles: 65 were pregnant women of late  reproductive age (group I), 58 were of active reproductive age (group II). Control group С consisted of 57 pregnant women of advanced reproductive age after the natural concept. The level of CRP was determined using the immunoturbidimetric method, albumin level – with a colorimetric analysis.

Results. It was found that, the CRP level in the blood serum increased over the course of the gestational process and was significantly lower in the first trimester compared to the second and third trimester in all studied groups of pregnant women. Pregnant women of group I had higher levels of serum CRP compared to women of group II and group C. The albumin level in the blood serum in the first trimester of pregnancy was statistically significantly higher compared to the second and third trimesters in all studied groups. Women in group I had lower levels of serum albumin compared to pregnant women in group II and group C.

Conclusions. Pregnancy induced in assisted reproductive technologies programs in women of late reproductive age is characterized by increased levels of CRP and decreased levels of albumin in peripheral blood serum, which requires the development of appropriate therapeutic and preventive correction during pregnancy.

Author Biographies

F.A. Khancha, Donetsk National Medical University, Kropivnytskyi

PhD, assistant, Department of Obstetrics and Gynecology

O.M. Nosenko, Odesa National Medical University, Odesa

MD, professor, Obstetrics and Gynecology Department

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Published

2024-03-15

How to Cite

Khancha, F., & Nosenko, O. (2024). Dynamics of C-reactive protein and albumin levels in women of late reproductive age during pregnancy induced in assisted reproductive technology programs. REPRODUCTIVE ENDOCRINOLOGY, (71), 58–66. https://doi.org/10.18370/2309-4117.2024.71.58-66

Issue

No. 71 (2024)

Section

Pregnancy and childbirth

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Copyright (c) 2024 Ф.О. Ханча, О.М. Носенко

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