Non-hormonal methods of correction of climacteric disorders in women


  • T.F. Tatarchuk SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”; State Scientific Institution “Center for Innovative Medical Technologies of the NAS of Ukraine”, Kyiv, Ukraine
  • S.I. Reheda SI “O.M. Lukyanova IPOG of the NAMS of Ukraine”; SSI “Center for Innovative Medical Technologies of the NAS of Ukraine”, Kyiv, Ukraine
  • N.V. Kosei SI “O.M. Lukyanova IPOG of the NAMS of Ukraine”; SSI “Center for Innovative Medical Technologies of the NAS of Ukraine», Kyiv, Ukraine
  • N.F. Zakharenko SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”, Kyiv, Ukraine
  • K.D. Plaksiieva State Scientific Institution “Center for Innovative Medical Technologies of the NAS of Ukraine”, Kyiv, Ukraine



menopause, climacteric syndrome, herbal medicine


Objective of the study: to optimize non-hormonal therapy of menopausal syndrome in perimenopausal women.

Materials and methods. 60 female patients aged 40–55 years with mild climacteric disorders were examined. Group I included 30 women who received a psychological consultation with recommendations on lifestyle and dietary correction, group II included 30 women who received Ayurvedic herbal drug Zintago 10 ml three times a day for three months a psychological consultation with recommendations on lifestyle and dietary correction. Patients were tested before treatment and 1 and 3 months after therapy according to the following scales: Spielberger-Hanin, PSM-25, MRS, and according to the SF-36 scale before treatment and 3 months after.

Results. 1 (31.4 ± 1.9 points) and 3 (27.8 ± 2.3 points) months after treatment in the II group there was a significant (p < 0.05) decrease in the indicator of personal anxiety according to the Spielberger scale in comparison with the initial level. There was a decrease in the index of situational anxiety from 36.4 ± 1.9 points before treatment to 26.2 ± 1.7 points (p < 0.05) in group II after 3 months of therapy. There were no significant clinical results in group I.

According to the PSM-25 scale, a clinically significant effect was in both groups after 3 months of treatment, but in group II it was achieved faster, after only one month – from 154.7 ± 9.6 to 122.6 ± 8.3 points (p < 0.05).

According to the SF-36 scale, a significant improvement in the quality of life in group I after 3 months of therapy was only in the indicators of social functioning (from 54.6 ± 7.1 points before treatment to 73.8 ± 5.8 after 3 months of therapy, p <  0.05) and role functioning due to emotional state (from 57.3 ± 6.6 to 74.8 ± 4.6 points, p < 0.05), while patients of group II demonstrated a significant improvement in all domains of the SF-36 scale.

The somato-vegetative component of the MRS scale in the II group before treatment was 3.7 ± 0.06, and after 1 and 3 months it decreased to 3.4 ± 0.04 and 2.6 ± 0.06 points, respectively, (р < 0 ,05).

Already after 3 months of treatment there was a significant decrease in the indicators of psycho-emotional changes in all women, which indicates the feasibility of using psychoprophylactic drugs in patients with mild menopausal syndrome.

Conclusions. Psychological counseling can be used in perimenopausal women to correct the manifestations of menopausal syndrome (somato-vegetative and psychological components) and such mental health indicators as social and role functioning. The ayurvedic herbal compositions can enhance the effect of psychological counseling in perimenopausal women with mild menopausal syndrome.

Author Biographies

T.F. Tatarchuk, SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”; State Scientific Institution “Center for Innovative Medical Technologies of the NAS of Ukraine”, Kyiv

MD, professor, corresponding member of the NAMS of Ukraine, deputy director for research work, head of the Endocrine Gynecology Department;
Chief researcher, Department of Reproductive Health

S.I. Reheda, SI “O.M. Lukyanova IPOG of the NAMS of Ukraine”; SSI “Center for Innovative Medical Technologies of the NAS of Ukraine”, Kyiv

PhD, senior researcher, Reproductive Health Department;
Head of the Gynecology Department

N.V. Kosei, SI “O.M. Lukyanova IPOG of the NAMS of Ukraine”; SSI “Center for Innovative Medical Technologies of the NAS of Ukraine», Kyiv

MD, professor, chief researcher, Endocrine Gynecology Department;
Head of Department of Reproductive Health

N.F. Zakharenko, SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”, Kyiv

MD, professor, leading research fellow, Endocrine Gynecology Department

K.D. Plaksiieva, State Scientific Institution “Center for Innovative Medical Technologies of the NAS of Ukraine”, Kyiv

PhD, researcher, Department of Reproductive Health


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How to Cite

Tatarchuk, T., Reheda, S., Kosei, N., Zakharenko, N., & Plaksiieva, K. (2024). Non-hormonal methods of correction of climacteric disorders in women. REPRODUCTIVE ENDOCRINOLOGY, (71), 45–52.



Management of menopause