Clinical and pathogenetic parallels of the course of different endometrioid forms

Authors

  • В. М. Запорожан Odessa National Medical University, Ukraine
  • В. В. Євдокимова Odessa National Medical University, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2012.7.5-9

Keywords:

ендометріоз, діагностика, лікування, прогнозування

Abstract

A comparative analysis of the clinical manifestations of adenomyosis and external endometriosis showed the dependence of the intensity lesion on the duration of disease, presence of concomitant gynecological pathology, chronic virus infection and burdened genetic history. The role of polymorphisms of genes VEGF, GSTM1, ІL-8, IL-6 and TNF-α in the determination of risk external genital endometriosis (RR 2.31, CI 95% 1,1-3,6, p < 0.05). It was shown that the cytokine balance in women with adenomyosis and external endometriosis characterized by changes in the form of overproduction of proinflammatory cytokines TNF-α, IL-6, which correlates with the severity of clinical symptoms (r = 0,74, p < 0,01). In a clinical study demonstrated the effectiveness of the use of drugs with severe procytokine activity in treatment of endometriosis.

Author Biographies

В. М. Запорожан, Odessa National Medical University

MD, Professor, Academician of Academy of Medical Sciences of Ukraine, Rector, Head of the Obstetrics and Gynaecology Department № 1

В. В. Євдокимова, Odessa National Medical University

PhD, Assistant professor of obstetrics and gynecology department №1

References

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Published

2012-10-14

How to Cite

Запорожан, В. М., & Євдокимова, В. В. (2012). Clinical and pathogenetic parallels of the course of different endometrioid forms. REPRODUCTIVE ENDOCRINOLOGY, (7), 5–9. https://doi.org/10.18370/2309-4117.2012.7.5-9

Issue

No. 7 (2012)

Section

Gynecology

License

Copyright (c) 2014 В. М. Запорожан, В. В. Євдокимова

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