Metabolic syndrome and hyperproliferative endometrial processes

Authors

  • Т. Ф Татарчук Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine, Ukraine
  • Н. Ю. Педаченко Shupyk National Medical Academy of Postgraduate Education, Ukraine
  • З. Б. Хомінська Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2014.16.61-69

Keywords:

metabolic syndrome, obesity, endometrial hyperplasia, adypokines, Tazalok™, lifestyle modification

Abstract

The article discusses mechanisms of action of metabolic syndrome and related dysfunction of adipose tissue in the development hyperproliferative processes of endometrМОдm. The results of testiнг the program of lifestyle modification we have developed, shows the reduction of the mass of adipose tissue in the abdominal region, the enhancement of the quality of life and the contribution to preservation of reproductive potential in women with metabolic syndrome. 

Author Biographies

Т. Ф Татарчук, Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine

MD, Dr. Sci., Professor, Head of the Department of Endocrine Gynecology

Н. Ю. Педаченко, Shupyk National Medical Academy of Postgraduate Education

Ph.D., Assistant of Professor of the Obstetrics, Gynecology and Perinatology Department

З. Б. Хомінська, Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine

Dr. Sci., Professor, Head of Department of Laboratory of Endocrinology with a group of Biochemistry

References

  1. Voronenko (Pedachenko), N.Y. «Impact of overweight on the development of hyperplastic processes of the endometrium in women of late reproductive age.» Women’s Health, 10 (2010): 127-129.
  2. Voronenko (Pedachenko), N.Y. «Biological effects of adipokines and their interrelated system at obesity as a major component of the metabolic syndrome.» Medicine: Scientific-Practical Journal. A peer-reviewed journal, 3 (2013): 35-42.
  3. Voronenko (Pedachenko), N.Y. «Influence dysfunction zhirovoĭ tissue development endometrial hyperplasia.» Medicine sogodnі i tomorrow, 1 (2013): 140-153.
  4. Tatarchuk, T.F. Voronenko, N.Y. Hominskaya, Z.B. Kapshuk, I.N. Tonkovid, O.B. «Benign breast disease and metabolic syndrome.» Мodern Medicine: current issues. – Novosibirsk: Publish house «Seebach», (2013): 6-23.
  5. Tatarchuk, T.F. Voronenko, N.Y. Kossey, N.V. Ganjiy, I.J. Kapshuk, I.M. «Pathogenetic aspects of reproductive health in women with metabolic syndrome.» Women’s Health, 6 (2011): 155-160.
  6. Caldefie-Chézet, Dubois, V. Delort, L. Rossary, A. Vasson, M.P. «F. Leptin: Involvement in the pathophysiology of breast cancer.» Ann Endocrinol (Paris), 74(2) (2013): 90-101.
  7. Cavanagh, D. Fiorica, J.V. Hoffman, M.S. Durfee, J. Nicosia, S.V. «Adenocarcinoma of the endometrМОдm: an institutional review.» Cancer Control, 6 (1999): 354-360.
  8. Clark, T.J. Neelakantan, D. Gupta, J.K. «The management of endometrial hyperplasia: an evaluation of current practice.» Eur J Obstet Gynecol Reprod Biol., 125 (2006): 259-264.
  9. «Group REA-SPcw Revised 2003 consensus on diagnostic criteria and loнг-term health risks related to polycystic ovary syndrome (PCOS).» Hum Reprod, 19 (2004): 41-47.
  10. Horn, L.C. Meinel, A. Handzel, R. Einenkel, J. «Histopathology of endometrial hyperplasia and endometrial carcinoma: an update» Ann Diagn Pathol, 11 (2007): 297–311.
  11. Jemal, A. Siegel, R. Ward, E. Murray, T. Xu, J. Thun, M.J. «Cancer statistics, 2007.» CA Cancer J Clin.,57 (2007): 43-66.
  12. Kadowaki, T. Yamauchi, T. Kubota, N. Hara, K. Ueki, K. Tobe, K. «Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest, 116 (2006): 1784-1792.
  13. Kazandi, M. Okmen, F. Ergenoglu, A.M. Yeniel, A.O. Zeybek, B. Zekioglu, O. Ozdemir, N. «Comparison of the success of histopathological diagnosis with dilatation-curettage and Pipelle endometrial sampliнг.» J Obstet Gynaecol, 32(8) (2012): 790-794.
  14. Kim, J.Y. van de Wall, E. Laplante, M. Azzara, A. Trujillo, M.E. Hofmann, S.M. Schraw, T. Durand, J.L. Li, H. Li, G. Jelicks, L.A. Mehler, M.F. Hui, D.Y. Deshaies, Y. Shulman, G.I. Schwartz, G.J. Scherer, P.E. «Obesity-associated improvements in metabolic profile through expansion of adipose tissue.» J Clin Invest, 117 (2007): 2621-2637.
  15. Samaras, K. Botelho, N.K. Chisholm, D.J. Lord, R.V. «Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes.» Obesity (Silver Spriнг), 18(5) (2010): 884-889.
  16. Sarcar, F.H. Adsule, S.Padhye, S. et al. «The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy.» Mini Rev. Med. Chem,6 (2006): 401-407.
  17. Skurk, T. Alberti-Huber, C. Herder, C. Hauner, H. «Relationship between adipocyte size and adipokine expression and secretion.» J Clin Endocrinol Metab, 92 (2007): 1023-1033.
  18. Stefan, N. Hennige, A.M. Staiger, H. Machann, J. Schick, F. Schleicher, E. Fritsche, A. Häriнг, H.U. «High circulatiнг retinol-bindiнг protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans.» Diabetes Care, 30 (2007): 1173-1178.
  19. Taksali, S.E. Caprio, S. Dziura, J. Dufour, S. Calí, A.M. Goodman,T.R. Papademetris, X. Burgert, T.S. Pierpont, B.M. Savoye, M. Shaw, M. Seyal, A.A. Weiss, R. «High visceral and low abdominal subcutaneous fat stores in the obese adolescent: a determinant of an adverse metabolic phenotype.» Diabetes, 57 (2008): 367-371.
  20. Weiss, R. Dufour, S. Groszmann, A. Petersen, K. Dziura, J. Taksali, S.E. Shulman, G. Caprio, S. «Low adiponectin levels in adolescent obesity: a marker of increased intramyocellular lipid accumulation» J Clin Endocrinol Metab, 88 (2003): 2014-2018.
  21. Widra, E.A. Dunton, C.J. McHugh, M. Palazzo, J.P. «Endometrial hyperplasia and the risk of carcinoma.» Int J Gynecol Cancer, 5 (1995): 233-235.

Published

2014-07-11

How to Cite

Татарчук, Т. Ф., Педаченко, Н. Ю., & Хомінська, З. Б. (2014). Metabolic syndrome and hyperproliferative endometrial processes. REPRODUCTIVE ENDOCRINOLOGY, (16), 61–69. https://doi.org/10.18370/2309-4117.2014.16.61-69

Issue

Section

Gynecology