Estrogen-associated regulation of the bone tissue remodeling

Authors

  • В. В. Поворознюк Gerontology Institute named after D.F. Chebotarev of Ukrainian NAMS, Ukraine
  • Н. А. Резниченко Donetsk National Medical University named after Mахіm Gorkii, Ukraine
  • Э. А. Майлян Donetsk National Medical University named after Mахіm Gorkii, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2014.15.14-18

Keywords:

Menopause, estrogens, estrogen receptors, osteoblasts, osteoclasts, osteoporosis

Abstract

The important role of an estrogen in a bone tissue metabolism regulation is proved. Irrefutable evidence of estrogen direct influence on bone tissue cell function through estrogen receptors is obtained. As a result of estrogen linking with the receptors, an estrogen is capable to activate tens of genes in osteoblasts and osteoclasts. The result of foregoing is the increase of osteoblasts and osteocytes functional activity, and also increase of the osteoclasts apoptosis and the osteoclastogenesis inhibition. Finally, these properties of the estrogen predetermine their protective role against the bone resorption.

Author Biographies

В. В. Поворознюк, Gerontology Institute named after D.F. Chebotarev of Ukrainian NAMS

MD, Professor, honoured worker of science and technology of Ukraine, Head of the Department of the Clinical Physiology and Pathology of the Musculoskeletal System

Н. А. Резниченко, Donetsk National Medical University named after Mахіm Gorkii

MD, Professor, Department of Obstetrics and Gynecology

Э. А. Майлян, Donetsk National Medical University named after Mахіm Gorkii

PhD, associate professor, Department of Clinical Immunology, Allergology and Endocrinology

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Published

2014-07-10

How to Cite

Поворознюк, В. В., Резниченко, Н. А., & Майлян, Э. А. (2014). Estrogen-associated regulation of the bone tissue remodeling. REPRODUCTIVE ENDOCRINOLOGY, (15), 14–18. https://doi.org/10.18370/2309-4117.2014.15.14-18

Issue

No. 15 (2014)

Section

Review

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Copyright (c) 2014 В. В. Поворознюк, Н. А. Резниченко, Э. А. Майлян

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