High-risk pregnancy: effectiveness of personalized pregravid preparation and positive perinatal experience





high risk pregnancy, micronutrient status, calcitriol, vitamin and mineral complex


Research objective: to study the possibilities of improving perinatal results by optimizing pergravid preparation in women with high perinatal risk.
Materials and methods. The first stage – a cross-sectional study – consisted in determining the vitamin D (VD) status and assessing the course of pregnancy in 459 women in the II and III trimester; the second stage was a randomized controlled study of women with VD deficiency in group IIA (planning stage, 54 women) and IIB (I trimester, 60 women), who received the vitamin and mineral complex (VMC) Pregna-5 with a high calcitriol content and perinatal results were evaluated. VD in the blood was determined by the enzyme-linked immunosorbent assay.
Results. VD level was optimal only in 30.7% of pregnant women (group ІА), in 69.3% of women its insufficiency or deficiency was found (group ІB). The frequency of threatened termination (9.9 vs. 45.6%; p < 0.01), preeclampsia (2.0 vs. 11%; p < 0.05), intrauterine growth retardation (7% only in group IIB, p < 0.01) was significantly higher against the background of BD deficiency. Normalization of the VD level (groups IIA and IIB) after VMC administration was observed within 1–3 months. Pregnancy complications value was higher in the group where the VMC was started in the first trimester: early gestosis (15 vs. 28.57%; p < 0.05), the threat of termination (22.2 vs. 36.7%; p < 0.05), bacterial vaginosis (7.4 vs. 31.7%; p < 0.05), placental dysfunction (18.5 vs. 40.0%; p <0.01), placental pathology in group IIB was detected 2–3 times more often. The differences between the preeclampsia (1.9 vs. 6.7%; p > 0.05) and anemia (16.6 vs. 28.3%; p > 0.05) were insignificant. Analysis of the childbirth results showed a significantly higher frequency of cesarean sections in group IIB (38.3 vs. 22.2%; p < 0.05), the average weight of newborns was less (3299.11 ± 128 g vs. 3643.24 ± 136 g; p < 0.01). The most effective was the VMC start at the stage of pregnancy planning (F = 13.35482; p = 0.000016); a significant difference was revealed in the course of pregnancy in the groups where VMC started in the first, second and third trimesters of pregnancy (Q = 4.67, p = 0.00458).
Conclusions. Timely donation of VMC with a high content of cholecalciferol in women with high perinatal risk may lead to a positive course of pregnancy. Further research is required to obtain a convincing evidence base.

Author Biographies

G.S. Manasova, Odesa National Medical University, Odesa

MD, professor, Department of Obstetrics and Gynecology No. 2

N.V. Didenkul, Municipal Non-Profit Enterprise “City Clinical Hospital No. 1” of the Odesa City Council, Odes

PhD, obstetrician-gynecologist

N.V. Kuzmyn, Odesa National Medical University; Municipal Non-Profit Enterprise “Maternity Hospital No. 5” of the Odessa City Council, Odesa

Graduate student, Department of Obstetrics and Gynecology;
Head of the 2nd Obstetrics Department


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How to Cite

Manasova, G., Didenkul, N., & Kuzmyn, N. (2021). High-risk pregnancy: effectiveness of personalized pregravid preparation and positive perinatal experience. REPRODUCTIVE ENDOCRINOLOGY, (62), 34–41. https://doi.org/10.18370/2309-4117.2021.62.34-41



Treatment of infertility and pregnancy