From menarche to menopause
DOI:
https://doi.org/10.18370/2309-4117.2020.56.18-22Keywords:
summit, menopause, menopausal hormone therapy, estradiol, dydrogesterone, FemostonAbstract
On September 11–12, 2020, in Kyiv hosted the International Women's Health Summit “From Menarche to Menopause” with the participation of leading foreign and domestic experts in the field of obstetrics and gynecology. The event was devoted to such topical topics as miscarriage, infertility, menstrual irregularities, menopausal hormone therapy (MHT).
The current concern in clinical practice is not overuse of MHT, but it underutilization, and the fact that only a small number of women with impaired quality of life through menopausal symptoms receive treatment, despite that they perfectly fit the patient's profile for such therapy.
All types of MHT are characterized by following effects: a positive effect on the cardiovascular system if MHT was start before 60 ages or in the first 10 years after menopause onset; the mortality rate from all causes is not increased in patients on MHT. The “ideal” MHT should relieve vasomotor symptoms, influence urogenital symptoms, prevent fractures and bone loss, protect the cardiovascular system and endometrium, and should not increase the risks of breast cancer, deep vein thrombosis and pulmonary embolism. Estradiol + dydrogesterone (Femoston®) scheme fits perfectly into these criteria. Femoston® is an oral MHT preparation that is effective in relieving symptoms of estrogen deficiency with a proven safety profile on the cardiovascular system and breast. This drug helps to reduce the manifestations of symptoms of estrogen deficiency, increase bone mineral density, and has a positive effect on metabolic processes. Numerous studies have shown that combination of estradiol + dydrogesterone is not only highly effective against menopausal symptoms, but also extremely important features, in particular, a proven safety profile for breast cancer.
References
- United Nations Department of Economic and Social Affairs: Population Division. Ukrainian population in 2020. Available from: [https://countrymeters.info/ru/Ukraine], last accessed Dec 12, 2020.
- Rossouw, J.E., Anderson, G.L., Prentice, R.L., et al. “Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial.” JAMA 288.3 (2002): 321–33.
- Instruction for medical use of FEMOSTON® drug 1/10, 2/10 from 01.23.2017.
- Instruction for medical use of FEMOSTON® CONTI drug from 01.23.2017.
- Instruction for medical use of FEMOSTON® CONTI MINI drug from 03.21.2019.
- Cieraad, D., Conradt, C., Jesinger, D., Bakowski, M. “Clinical study comparing the effects of sequential hormone replacement therapy with oestradiol/dydrogesterone and conjugated equine oestrogen/norgestrel on lipids and symptoms.” Arch Gynecol Obstet 274.2 (2006): 74–80. DOI: 10.1007/s00404-006-0132-4
- Lees, B., et al. “The prevention of osteoporosis using sequential low-dose hormone replacement therapy with estradiol-17β and dydrogesterone.” Osteoporosis Int 12 (2001): 251–8.
- Godsland, I.F., Manassiev, N.A., Felton, C.V., et al. “Effects of low and high dose oestradiol and dydrogesterone therapy on insulin and lipoprotein metabolism in healthy postmenopausal women.” Clin Endocrinol (Oxf) 60.5 (2004): 541–9. DOI: 10.1111/j.1365-2265.2004.02017.x
- Schneider, C., Jick, S.S., Meier, C.R. “Risk of cardiovascular outcomes in users of estradiol/dydrogesterone or other HRT preparations.” Climacteric 12.5 (2009): 445–53. DOI: 10.1080/13697130902780853
- Canonico, M., Oger, E., Plu-Bureau, G., et al.; Estrogen and Thromboembolism Risk (ESTHER) Study Group. “Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study.” Circulation 115.7 (2007): 840–5. DOI: 10.1161/CIRCULATIONAHA.106.642280
- Lyytinen, H., et al. “Breast cancer risk in postmenopausal women using estradiol-progestogen therapy.” Obst Gyn 113 (2009): 65–73.
- Fournier, A., et al. “Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study.” Breast Cancer Res Treat 107 (2008): 103–11.
- National Comprehensive Cancer Network. NCCN guidelines for detection, prevention, & risk reduction. Available from: [https://www.nccn.org/professionals/physician_gls/default.aspx#detection], last accessed Dec 12, 2020.
- European Society for Medical Oncology. Guidelines. Available from: [https://www.esmo.org/guidelines], last accessed Dec 12, 2020.
- Santen, R.J., Mansel, R. “Benign breast disorders.” N Engl J Med 353.3 (2005): 275–85. DOI: 10.1056/NEJMra035692
- International Menopause Society. Available from: [https://www.imsociety.org/], last accessed Dec 12, 2020.
- Australian Menopause Society. Available from: [https://www.menopause.org.au/], last accessed Dec 12, 2020.
- Shestakova, I. G. “Influence of hormone replacement therapy with Femoston on body weight and carbohydrate metabolism in perimenopausal women.” Problems of reproduction 2 (2001): 46–8.
- Schindler, A.E., Campagnoli, C., Druckmann, R., et al. “Classification and pharmacology of progestins.” Maturitas 61.1–2 (2008): 171–80. DOI: 10.1016/j.maturitas.2008.11.013
- Amy, J.J. “Femoston®: Effects on bone and quality-of-life.” Eur Menop J 2 (Suppl) (1995): 16–22.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Т. Ф Татарчук
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.