Пробиотики в акушерстве и гинекологии. Обзор литературы

Л. М. Самчинская

doi:10.18370/2309-4117.2020.54.110-117

Authors

Л. М. Самчинская “Reproductive endocrinology” Journal, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2020.54.110-117

Keywords:

probiotics, lactobacillus, biocenosis, vaginal dysbiosis, Florica

Abstract

A modern probiotic preparation should include an effective combination of microorganisms with proven probiotic properties, i.e. produce lactic acid, hydrogen peroxide and bactericins, have the ability to grow and colonize, allowing them to become temporary for the period of treatment, or permanent inhabitants of vagina or other micro-ecologies. The World Health Organization (WHO) has outlined certain guidelines for a bacterial strain to be used as a probiotic: it must be capable of survival during passage through the stomach and intestines (for oral forms), resistant to the effects of antibiotics, tested for side effects and adverse effects in humans. Currently, there are only a few recognized lactobacilli or bifidobacterial strains which meet WHO criteria.

The main indication for the probiotics use in gynecology is the treatment of bacterial vaginosis, candidiasis and recurrent infections of the urinary tract. Numerous studies have shown the clinical efficacy of introducing probiotics into treatment regimens for these diseases. Probiotics are able to adhere to vaginal epithelial cells and form a protective layer (biofilm) that provides a barrier against infectious pathogens.

Vaginal biocenosis disorders often lead to complicated pregnancy, miscarriage, development of placental insufficiency, premature birth and intrauterine infection of the fetus, various pathologies in the newborn (impaired immunity, allergic diseases, etc.). Therefore, the condition of the vaginal microflora of woman is important for health of her child. Its correction is needed at the stage of preconceptional preparation, as well as during pregnancy. At the same time, probiotics are not only beneficial, but also safe for pregnant and lactating women. Vaginal suppositories Florica showed effectiveness and tolerability in maintaining the normal vaginal microbiota balance and prevent recurrence of bacterial vaginosis and vaginal dysbiosis whereas in the absence of its use, the frequency of diseases recurrence was 35% within 6 months

Author Biography

Л. М. Самчинская, “Reproductive endocrinology” Journal

Medical editor

References

World Gastroenterological Organisation. Probiotics and prebiotics: Practical recommendations of the World Gastroenterological Organization. VGO (2008): 24 p.
Potapov, V.A. “Probiotics in gynecology: another fashion or a conscious need.” Local doctor 5 (2016): 33.
Lobanov, G.F. “The key role of probiotics in the system of optimized rehabilitation measures is associated with complicated forms of urogenital chlamydia under conditions of environmental disadvantage.” Woman's Health 1.33 (2008): 223–6.
Yankovskyi, D.S., Dyment, G.S. “Modern aspects of the problem of microecology and dysbiosis.” Woman’s Health 4.24 (2005): 209–18.
Yankovskyi, D.S., Dyment, G.S. Microorganisms and human health. Kyiv. Expert LTD (2008): 552 p.
Nazarenko, L.G., Solovyova, N.P. “The use of oral probiotics as an alternative clinical strategy for the prevention of obstetric and perinatal infections.” Woman's Health 6.82 (2013): 91–6.
Yankovskyi, D.S. Human microbial ecology. Modern possibilities of its maintenance and restoration. Kyiv. Expert LTD (2005): 362 p.
Jassawala, M.J. “Probiotics and Women’s Health.” Obstet Gynecol India 57.1 (2007): 19–21.
Reid, G., Jass, J., Sebulshy, N.T., et al. “Potential uses of probiotics in clinical practice.” Clin Microbiol Rev 16 (2003): 658–72.
Uzar, I. “Probiotics in gynaecology.” Herba polonica 57.2 (2011): 66–70.
Osset, J., et al. “Assesment of the capacity of Lactobacillus to inhibit the growth of uropathogens and block their adhesion to vaginal epithelial cells.” J Infect 183.3 (2001): 485–91.
Kochan, P. “Selected female genitourinary tract infections and their treatment according to CDC. WHO/FAO criteria for probiotics and their use in gynecology basing on current research.” Gin Praсt 87.6 (2005): 11–18.
Zhuk, S.I., Us, I.V., Shlyakhtina, A.A. “Oral probiotics – the key to a successful pregnancy.” Woman's Health 10.116 (2016): 56–8.
Tomaszewski, J. “Probiotcs to prevent infections.” Postępy w Medycynie 10 (2008): 173.
MacPhee, R.A., Hummelen, R., Bisanz, J.E., et al. “Probiotic strategies for the treatment and prevention of bacterial vaginosis.” Expert Opin Pharmocother 11.18 (2010): 2985–95.
Hummelen, R., Сhangulacha, J., Butamanya, N.L., et al. “Lactobacillus rhamnosus GR¬1 and L. reuteri RC¬ 14 to prevent or cure bacterial vaginosis among women with HIV.” Int J Gyneacol Obstet 111.3 (2010): 245–8.
Tikhomirov, A.L., Oleinik, C.G.“Probiotics in the complex treatment of vulvovaginal candidiasis.” Effective pharmacotherapy 4 (2007): 14–20.
Jun-Mo Kim, Yoo Jin Park. “Probiotics in the Prevention and Treatment of Postmenopausal Vaginal Infections.” J Menopausal Med 23.3 (2017): 139–45.
Oakeshott, P., at al. “Association between bacterial vaginosis or chlamy¬dial infection and miscarriage before 16 weeks’ gestation: prospective commu¬nity based cohort study.” BMJ 325.7376 (2002): 1334.
Reid, G., Bocking, A. “The potential for probiotics to prevent bacterial vaginosis and preterm labor.” Am J Obstet Gynecol 189 (2003): 1202¬1208.
Reid, G., Hammond, J.A., Bruce, A.W. “Effect of lactobacilli oral supplement on the vaginal microflora of antibiotic treated patients: randomized placebo controlled study.” Nutraceut Food 8 (2003): 145–8.
Plotnikova, E.Y., Zakharova, Y.V. “Probiotics during pregnancy and lactation: what is the benefit?” Russian Medical Journal “Medical Review” 17 (2015): 1038.
Schultz, M., Göttl, C., Young, R.J., et al. “Administration of oral probiotic bacteria to pregnant women causes temporary infantile colonization.” J Pediatr Gastroenterol Nutr 38 (2004): 293–7.
Gueimonde, M., Sakata, S., Kalliomäki, M., et al. “Effect of maternal consumption of Lactobacillus GG on transfer and establishment of fecal bifidobacterial microbiota in neonates.” J Pediatr Gastroenterol Nutr 42 (2006): 166–70.
Vitali, B., Cruciani, F., Baldassarre, M.E., et al. “Dietary supplementation with probiotics during late pregnancy: outcome on vaginal microbiota and cytokine secretion.” BMC Microbiol 12 (2012): 236.
Kukkonen, K., Savilahti, E., Haahtela, T., et al. “Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double- blind, placebo-controlled trial.” Pediatrics 122 (2008): 8–12.
Kalliomaki, M., Salminen, S., Poussa, T., Isolauri, E. “Probiotics during the first 7 years of life: accumulative risk reduction of eczema in a randomized, placebo-controlled trial.” J Allergy Clin Immunol 119 (2007): 1019–21.
Boyle, R.J., Mah, L.J., Chen, A., et al. “Effects of Lactobacillus GG treatment during pregnancy on the development of fetal antigen-specific immune responses.” Clin Exp Allergy 38 (2008): 1882–90.
Wickens, K., Black, P.N., Stanley, T.V.; Probiotic Study Group. “A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial.” J Allergy Clin Immunol 122 (2008): 788–94.
Pelucchi, C., Chatenoud, L., Turati, F., et al. “Probiotics supplementation during pregnancy or infancy for the prevention of atopic dermatitis: a meta-analysis.” Epidemiol 23.3 (2012): 402–14.
Bertelsen, R.J., Brantsæter, A.L., Magnus, M.C., et al. “Probiotic milk consumption in pregnancy and infancy and subsequent childhood allergic diseases.” J Allergy Clin Immunol 133.1 (2014): 165–171.e1-8.
Laitinen, K., Poussa, T., Isolauri, E.; Nutrition, Allergy, Mucosal Immunology and Intestinal Microbiota Group. “Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomised controlled trial.” Br J Nutr 101 (2009): 1679–87.
Luoto, R., Laitinen, K., Nermes, M., Isolauri, E. “Impact of maternal probiotic-supplemented dietary counseling on pregnancy outcome and prenatal and postnatal growth: a double- blind, placebo-controlled study.” Br J Nutr 103.12 (2010): 1792–9.
Asemi, Z., Samimi, M., Tabassi, Z., et al. “Effect of daily consumption of probiotic yoghurt on insulin resistance in pregnant women: a randomized controlled trial.” Eur J Clin Nutr 67.1 (2013): 71–4.
Van de Vusse, L., Hanson, L., Safdar, N. “Perinatal outcomes of prenatal probiotic and prebiotic administration: an integrative review.” J Perinat Neonatal Nurs 27.4 (2013): 288–301.
Ministry of Health of Ukraine. Order No. 582 “On Approval of Clinical Protocols on Obstetric and Gynecological Aid” from 15.12.2003.
Pyrogova, V.I., Feita, Y.R., Shurpiak, S.O. “Clinical efficacy of correction of vaginal microbiotypes in women with reproductive health disorders and postpartum complications in the history.” Woman’s Health 5.131 (2018): 36–9.
Tlustova, T. “The role of the vaginal microflora in the reproductive health of women and the methods of its correction.” News of medicine and pharmacy 582 (2016): 11–4.
Dushkina, E.A., Kira, E.F., Badikova, N.V. “Acid-containing drugs in gynecological practice.” Effective pharmacotherapy. Obstetrics and gynecology 2 (2012).