Treatment experience of late acne in active reproductive aged women

Authors

DOI:

https://doi.org/10.18370/2309-4117.2020.53.70-74

Keywords:

late acne, treatment, women, active reproductive age

Abstract

Current guidelines of acne treatment are not effective in different women. Dissatisfaction with the esthetic results of treatment creates the need to optimize the treatment of late acne in active reproductive aged women.

Objective of the study: to evaluate the effectiveness of developed comprehensive method for the treatment of late acne in active reproductive aged women.

Materials and methods. 32 patients with acne tarda aged 25–40 years were examined and treated, including women with acne of I degree of severity – 18.8%, II degree – 30.6%, III degree – 46.8%. Biophysical parameters of skin (fat, moisture, elasticity and erythema degree) were determined before treatment, after 3 and 6 months and expressed in arbitrary units. The control group consisted of 8 conditionally healthy women of the corresponding age without acne. Treatment efficacy was evaluated in 3 comparison groups: group 1 – 10 patients who received conventional therapy; group 2 – 12 patients in whom traditional therapy was combined with combined oral contraceptive (COC) Belara, group 3 – 10 patients in whom traditional therapy was combined with COC Belara and Richter CycloBalance.

Results. A comparative analysis of the inflammatory dynamics (papules, pustules, nodes, cysts) and non-inflammatory rash elements (open and closed comedones), skin biophysical parameters (fat, porosity, hydration, erythema, elasticity) before treatment, after 3 and 6 months of therapy showed the advantage of combined use COC Belara and Richter CycloBalance in the complex treatment of late acne in active reproductive aged women.

Conclusion. Complex therapy of late acne in active reproductive aged women with COC Belar and Richter CycloBalance increases the effectiveness of therapy and aesthetic skin status.

Author Biographies

Т. В. Проценко, VERUM Medical Center, Kyiv

MD, professor, honored doctor of Ukraine, organizer of the School of Clinical Dermatology, dermatovenerologist

А. Б. Гордийчук, Kyiv

PhD

References

  1. Arowojolu, A.O., Gallo, M.F., Lopez, L.M., Grimes, D.A. “Combined oral contraceptive pills for treatment of acne.” Cochrane Database Syst Rev 6 (2012): CD004425.
  2. Carlomagno, G., Unfer, V., Roseff, S. “The D-chiroinositol paradox in the ovary.” Fertil Steril 95 (2011): 2515–6.
  3. Chattopadhayay, R., Ganesh, A., Samanta, J., et al. “Effect of follicular fluid oxidative stress on meiotic spindle formation in infertile women with polycystic ovarian syndrome.” Gynecol Obstet Invest 69 (2010): 197–202.
  4. Chiu, T.T., Tam, P.P. “A correlation of the outcome of clinical in vitro fertilization with the inositol content and embryotrophic properties of human serum.” J Assist Reprod Genet 9 (1992): 524–30.
  5. Genazzani, A.D., Lanzoni, C., Ricchieri, F., et al. “Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome.” Gynecol Endocrinol 24 (2008): 139–44.
  6. Gerasimenko, J.V., Flowerdew, S.E., Voronina, S.G., et al. “Bile acids induce Ca release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors.” J Biol Chem 281.52 (2006): 40154–63.
  7. Zaenglein, A.L., Pathy, A.L., Schlosser, B.J., et al. “Guidelines of care for the management of acne vulgaris.” Journal of the American Academy of Dermatology (2016). DOI: 10.1016/j. jaad.2015.12.037
  8. Harwood, K., Vuguin, P., Dimartino-Nardi, J. “Current approaches to the diagnosis and treatment of polycystic ovarian syndrome in youth.” Horm Res 68 (2007): 209–17.
  9. Dréno, B., Thiboutot, D., Gollnick, H., et al.; Global Alliance to Improve Outcomes in Acne. “Large-scale worldwide observational study of adherence with acne therapy.” Int J Dermatol 49.4 (2010): 448.
  10. Larner, J. “D-chiro-inositol – its functional role in insulin action and its deficit in insulin resistance.” Int J Exp Diabetes Res 3.1 (2002):. 47–60.
  11. Asai, Y., Baibergenova, A., Dutil, M., et al. “Management of acne: Canadian clinical practice guideline.” CMAJ 188.2 (2016). DOI: 10.1503/cmaj.140665
  12. Pal, L., Jindal, S., Witt, B.R., Santoro, N. “Less is more: increased gonadotropin use for ovarian stimulation adversely influences clinical pregnancy and live birth after in vitro fertilization.” Fertil Steril 89 (2008): 1694–1701.
  13. Rapiejko, P.J., Northup, J.K., Evans, T., et al. “G-proteins of fat-cells. Role in hormonal regulation of intracellular inositol 1,4,5-trisphosphate.” Biochem J 240.1 (1986): 35–40.
  14. Teede, H.J., Misso, M.L., Costello, M.F., et al. “Recommendations from the International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.” Human Reproduction 33.9: 1602–18. DOI: 10.1093/humrep/dey256
  15. Novoselov, A.V. “Acne as an interdisciplinary problem.” Archives of Obstetrics and Gynecology named after V.F. Snegirev 4.1 (2017): 29–35.
  16. Kubanov, A.A. “Aspects of the pathogenesis and modern treatment of acne.” Attending physician 11 (2016): 30–1.
  17. Goginava, E.P. “Modern Acne Treatment Algorithms.” Gastroenterology of St. Petersburg 3–4 (2016): M7–M8.
  18. Golousenko, I.Y. “The choice of treatment for acne in women.” Doctor 2 (2015): 72–4.
  19. Golousenko, I.Y. “Acne therapy in women with ovarian hyperandrogenism and insulin resistance.” Bulletin of Dermatology and Venereology 1 (2013): 22–7.
  20. Grodnitskaya, E.E. “Combined oral contraceptives in the treatment of acne.” Obstetrics and gynecology 3 (2015): 100–2.
  21. Protsenko, T.V., Bogoslav, Y.P., Lukyanchenko, E.N. “Clinical and hormonal comparisons in late acne in women of various age groups.” Dermatovenerology. Cosmetology 1 (2017): 29–36.
  22. Tchaikovskaya, E.A., Parsagashvili, E.Z., Sofinskaya, G.V. “Hyaluronic acid in the form of a prodrug: theoretical foundations of drug development and clinical practice of their use.” Injection methods in cosmetology 2 (2017): 28–43.

Published

2020-07-10

How to Cite

Проценко, Т. В., & Гордийчук, А. Б. (2020). Treatment experience of late acne in active reproductive aged women. REPRODUCTIVE ENDOCRINOLOGY, (53), 70–74. https://doi.org/10.18370/2309-4117.2020.53.70-74

Issue

Section

Interdisciplinary consilium