Dopaminergic drugs for the prevention of menstrual disorders in girls with autoimmune thyroiditis

Authors

DOI:

https://doi.org/10.18370/2309-4117.2018.43.32-37

Keywords:

reproductive health, adolescence, autoimmune thyroiditis, prevention, menstrual disorders, Cyclodynon

Abstract

A disbalance of hypothalamic-pituitary-ovarian relations is noted in adolescent girls with autoimmune thyroiditis, due to heightened prolactin, LH, cortisol, lowered estradiol, progesterone, accompanied by changes in the functional state of ovaries per data of echographs and with possible further disruptions of reproductive health. Multidisciplinary observation algorithm for euthyroid girls with autoimmune thyroiditis was proposed. 88 girls of late adolescence (58 – main group, 30 – comparison group),

Vitex agnus-castus extract (1 tablet 1 time per day) and basic cyclic vitamin therapy, which is traditionally used in the practice of children’s gynecology: vitamin E – 200 mg, 1 capsule per day every second day, folic acid –

1 mg, 3 times per day on days 1–14 of the menstrual cycle, vitamin C – 100 mg, 2 times per day on 15–28 days of cycle. The girls of the comparison group was intended only cyclic vitamin therapy. Both surveyed groups received prophylactic correction for 3 months, the next assessment of the patient’s condition was performed after 3 months of further observation.

with autoimmune thyroiditis allowed for improved hormonal status, ovarian functional state per echography. Following use of the proposed prophylactic complex there over nine months.

Author Biographies

Л. В. Калугіна, SI “O.M. Lukyanova IPOG of the NAMS of Ukraine”

MD, leading researcher at the Endocrine Gynecology Department

І. В. Бачинська, National Children’s Specialized Hospital “Okhmatdyt”

Physician at the child and adolescent gynecology department

Н. В. Яроцька, SSI “Center for Innovative Medical Technologies”

Сounseling psychologist, researcher at the Department of Reproductive Health

References

  1. de Vries, L., Bulvik, S., Phillip, M. “Chronic autoimmune thyroiditis in children and adolescents: at presentation and during long-term follow-up.” Arch Dis Child 94 (2009): 33–7.
  2. Sarı, E., Karaoglu, A., Yeşilkaya, E. “Autoimmune Disorders – Current Concepts and Advances from Bedside to Mechanistic Insights.” In: Hashimoto’s Thyroiditis in Children and Adolescents. IntechOpen (2011): 27–40. Available from: [https://www.intechopen.com/books/autoimmune- disorders-current-concepts-and-advances-from-bedside-to- mechanistic-insights/hashimoto-s-thyroiditis-in-children-and- adolescents], last accessed Oct 29, 2018.
  3. Brown, R.S. “Autoimmune Thyroiditis in Childhood.” Journal of Clinical Research in Pediatric Endocrinology 5 (2013): 45–9.
  4. Tsisar, Y.V., Andriyets, O.A. “Influence of pathology of thyroid gland on menstrual function in girls of puberty age.” Bukovinian Medical Bulletin 2.58 (2011): 130–2.
  5. Tatarchuk, T.F. “Thyroid homeostasis and dyshormonal disorders of the female reproductive system.” Endocrine gynecology. Clinical essays 1 (2003): 303.
  6. Ganiel, M.A., Marwaha, R.K., Aggarwal, R., Singh, S. “High prevalence of polycystic ovary syndrome characteristics in girls with euthyroid chronic lymphocytic thyroiditis: a case- control study.” European Journal of Endocrinology 62 (2010): 1117–22.
  7. Ulrich, J., Goerges, J., Keck, C., et al. “Impact of Autoimmune Thyroiditis on Reproductive and Metabolic Parameters in Patients with Polycystic Ovary Syndrome.” Exp Clin Endocrinol Diabetes 126.4 (2018): 198–204.
  8. Ashrafi, M., Fallahian, M., Eshrati, B., Yazdi, R.S. “The Presence of Anti Thyroid and Anti Ovarian Auto-Antibodies in Familial Premature Ovarian Failure.” International Journal of Fertility and Sterility 1.4 (2008): 171–4.
  9. Poppe, K., Velkeniers, B., Glinoer, D. “The role of thyroid autoimmunity in fertility and pregnancy.” Nat Clin Pract Endocrinol Metab 4.7 (2008): 394–405.
  10. Tatarchuk, T.F., Kosei, N.V., Tutchenko, T.N. “Treatment of stress-induced luteal phase deficiency.” Women’s Health 3 (2016): 18–23.
  11. Ventskovska, I.B., Zagorodnyaya, I.B. “Stress-induced disorders of reproductive and sexual function.” Reproductive health. Eastern Europe 2.26 (2013): 113–9.
  12. Chatterjee, A., Chatterjee, R. “How stress affects female reproduction: An overview.” Biomedical Research 20.2 (2009): 79–83.
  13. Pavliutenkov, E.M. Conflicts: the essence and overcoming. Stress in pedagogical activity. Kharkiv. Publishing Group “Osnova” (2008): 224 p.
  14. Tsarkova, O.V., Velichko, N.I. “Stress in adolescence and ways to its overcome.” Science and Education 3 (2010).
  15. Siegmann, E.-M.; Muller, H.O., Luecke, C., et al. “Association of depression and anxiety disorders with autoimmune thyroiditis. A systematic review and meta- analysis.” JAMA Psychiatry 75.6 (2018): 577–84.
  16. Giynas, A.M., Uguz, F., Askin, R., Gonen, M.S. “The prevalence of depression and anxiety disorders in patients with euthyroid Hashimoto’s thyroiditis: a comparative study.” Gen Hosp Psychiatry 36 (2014): 95–8.
  17. Ott, J., Promberger, R., Kober, F., et al. “Hashimoto’s thyroiditis affects symptom load and quality of life unrelated to hypothyroidism: a prospective case-control study in women undergoing thyroidectomy for benign goiter.” Thyroid 21 (2011): 161–7.
  18. Yalcin, M.M., et al. “Is thyroid autoimmunity itself associated with psychological well-being in euthyroid Hashimoto’s thyroiditis?” EJ 64.4 (2017): 425–9.
  19. Tatarchuk, T.F., Zakharenko, N.F., Kosei, N.V., Bachinska, I.V. “Formation of autoimmune lesions of the ovaries in the pubertal period.” Georgian Medical News 6.279 (2018): 49–56.
  20. Bachinska, I.V. “Development of menstrual function and hormonal homeostasis of teenage girls with autoimmune thyroiditis.” Reproductive endocrinology 5.31 (2016): 60–4.
  21. Bakalov, V., Anasti, J., Calis, K., et al. “Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46, XX spontaneous premature ovarian failure.” Fertil Steril 84 (2005): 958–65.

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Published

2018-12-03

How to Cite

Калугіна, Л. В., Бачинська, І. В., & Яроцька, Н. В. (2018). Dopaminergic drugs for the prevention of menstrual disorders in girls with autoimmune thyroiditis. REPRODUCTIVE ENDOCRINOLOGY, (43), 32–37. https://doi.org/10.18370/2309-4117.2018.43.32-37

Issue

No. 43 (2018)

Section

Interdisciplinary problems

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Copyright (c) 2018 Л. В. Калугіна, І. В. Бачинська, Н. В. Яроцька

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