The influence of vitamin D deficiency on pregnancy

Authors

  • А. В. Бойчук Ternopil State Medical University of the MOH of Ukraine, Ukraine
  • Т. О. Буднік Ternopil municipal city hospital №2, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2017.33.73-76

Keywords:

vitamin D deficiency, pregnancy complication

Abstract

To date, vitamin D deficiency is considered one of the important health problems, which, according to WHO, has the nature of a pandemic – a deficit or deficiency of vitamin D is experienced by more than 1 billion people around the world. The situation regarding the vitamin D status in pregnant women and babies is especially worrisome. Based on researches, this part of the population is makes up the group of increased risk of D-hypovitaminosis states.

During pregnancy, the regulation of calcium hemostasis and the metabolism of vitamin D are subject of changes in order to supply calcium to the embryo. In case of insufficient amount of vitamin D, calcitriol precursor, or reduced calcium intake with food, the only source of calcium is the mother’s bone tissue, which can lead to demineralization and development of osteoporosis in pregnant women and other complications associated with hypocalcemia.

The article presents data on current views on the role of vitamin D in providing various functions of the body and, in particular, the role of vitamin D deficiency in the development of complications of pregnancy. Possible complications of pregnancy with vitamin D deficiency are preeclampsia, gestational diabetes, premature birth, etc. Although these conditions are well known, the connection with vitamin D is a new direction in the study of their pathogenetic chains. It is proved that vitamin D supplementation during pregnancy reduces the likelihood of these complications.

The authors of the article emphasize the need for taking preventive and therapeutic measures to eliminate the vitamin D deficiency both at the stage of pregravid preparation, and during pregnancy and lactation. In particular, when an insufficient amount of vitamin D and the inability to stay under the sunlight from the 28th to the 32nd week of pregnancy, it is recommended to prescribe vitamin D preparations in a dose corresponding to the daily requirement for 6–8 weeks. The need for a screening and targeted examination of pregnant women for vitamin D in the blood serum is indicated, which will allow correcting its level on time and preventing the complications.

Author Biographies

А. В. Бойчук, Ternopil State Medical University of the MOH of Ukraine

MD, professor, head of the Obstetrics and Gynaecology Department, Faculty of Postgraduate Education 

Т. О. Буднік, Ternopil municipal city hospital №2

Gynecologist 

References

  1. Povorozniuk, V.V. “The state of the problem of osteoporosis and other metabolic diseases of the skeleton in Ukraine.” News of Medicine and Pharmacy 3.487 (2014): 10–13.
  2. Semin, S.G., Volkova, L.V., Moiseyev, A.B., Nikitin, N.V. “Prospects for studying the biological role of vitamin D.” Pediatrics 91.2 (2012): 122–31.
  3. Schwartz, G.Y. “Vitamin D, D-hormone and alfacalcidiol: medical, molecular biological and pharmacological aspects.” Ukr Rheumatology Journal 3 (2009): 63–9.
  4. Heaney, R.P. “Vitamin D in health and disease.” Clin J Am Soc Nephrol 3.5 (2008): 1541–2535.
  5. Souberbielle, J.C., Body, J.S., Lappe, J.M., et al. “Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice.” Autoimune Rev 9.11 (2010): 709–15.
  6. Shylin, D.E. “Vitamin D hormone in the 21st century clinic: the pleiotropic aspects and laboratory evaluation (lecture).” Clinical laboratory diagnostics 12 (2010): 17–23.
  7. Grundman, M., Versen, H. “Vitamin D role’s in women’s reproductive health?” Reproductive Biology and Endocrinology 9.1 (2010): 146.
  8. Morris, H.A., Anderson, P.H. “Autocrine and paracrine actions of vitamin D.” Clin Biochem Rev 31.4 (2010): 129–38.
  9. Komisarenko, Y.I. “Vitamin D and its role in the regulation of metabolic disorders.” Lectures, reviews, news 4 (2013): 51–4.
  10. Holick, M.F., Binkley, N.C., Heyke, A., et al. “Treatment and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline.” Clin Endocrinol Metab 97.7 (2011): 1911–30.
  11. Povorozniuk, V.V. “Vitamin D deficiency in the population of Ukraine and factors of its development.” Reproductive Endocrinology 5.13 (2013): 7–13.
  12. Liu, N.Q., Kaplan, A.T., Lagishetty, V., et al. “Vitamin D and the regulation of placental inflammation.” J Immunol 186.10 (2011): 5968–74.
  13. Wortsman, J., Matsuoka, L.Y., Chen, T.C., et al. “Decreased bioavailability of vitamin D in obesity.” Am J Clin Nutr 72.3 (2000): 690–3.
  14. Haugen, M., Brantsaeter, A.L., Trogstad, L., et al. “Vitamin D supplementation and reduced risk of preec-lampsia in nulliparous women.” Epidemiology 20.5 (2009): 720–6.
  15. Baker, A.M., Haeri, S., Camargo, C.A., et al. “First-trimester maternal vitamin D status and risk for gestational diabetes (GDM) a nested case-control study.” Diabetes Metab Res Rev 28.2 (2011): 164–8.
  16. Bodnar, L.M., Catov, J.M., Simhan, H.N. “Maternal vitamin D deficiency increases the risk of preeclampsia.” Clin Endocrinol Metab 92.9 (2007): 3517–22.
  17. Grant, W.B. “Role of vitamin D in upregulating VEGF and reducing the risk of pre-eclampsia.” Clin Sci (Lond) 116.12 (2009): 871.
  18. Lau, S.L., Gunton, J.E., Athayde, N.P., et al. “Serum 25-hydroxyvitamin D and glycated haemoglobin levels in women with gestational diabetes mellitus.” Med J Aust 194.7 (2011): 334–7.
  19. Hollis, B.W., Johnson, D., Hulsey, T.C., et al. “Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness.” J Bone Miner Res 26.10 (2011): 2341–57.
  20. Cardus, A., Panizo, S., Encinas, M., et al. “1,25-dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter.” Atherosclerosis 204.1 (2009): 85–9.
  21. Sheth, J.J., Shah, A., Sheth, F.J., et al. “Does vitamin D play a significant role in type 2 diabetes?” BMC Endocr Disord 15 (2015): 5.
  22. Liu, N.Q., Lisse, T.S., Chun, R.F., et al. “Vitamin D: Oxidative Stress, Immunity, and Aging.” Endocrinology 151.6 (2010): 2423–32.
  23. Bolland, M.J., Grey, A., Gamble, G.D., Reid, I.R. “Calcium and vitamin D supplements and health out-comes: a reanalysis of the Women’s Health Initiative (WHI) limited-access data set.” Am J Clin Nutr 8 (2011): 1144.
  24. Sabour, H., Hossein-Nezhad, A., Maghbooli, Z., et al. “Relationship between pregnancy outcomes and ma-ternal vitamin D and calcium intake: A cross-sectional study.” Gynecol Endocrinol 22.10 (2008): 585–9.
  25. Hensel, K.J., Randis, T.M., Gelber, S.E., Ratner, A.J. “Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis.” Am J Obstet Gynecol 204.1 (2011): 41–9.

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Published

2017-02-24

How to Cite

Бойчук, А. В., & Буднік, Т. О. (2017). The influence of vitamin D deficiency on pregnancy. REPRODUCTIVE ENDOCRINOLOGY, (33), 73–76. https://doi.org/10.18370/2309-4117.2017.33.73-76

Issue

No. 33 (2017)

Section

Pregnancy and childbirth

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Copyright (c) 2017 А. В. Бойчук, Т. О. Буднік

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