Клінічна ефективність терапевтичних режимів прогестерону в програмі ЕКЗ в жінок із трубно-перитонеальним фактором безпліддя

О. В. Булавенко; І. Ю. Коцюбська

doi:10.18370/2309-4117.2016.32.64-68

Authors

О. В. Булавенко Vinnytsya National Pirogov Memorial Medical University, Ukraine
І. Ю. Коцюбська Vinnytsya National Pirogov Memorial Medical University, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2016.32.64-68

Keywords:

tuboperitoneal infertility, progesterone, IVF cycles, trigger of ovulation, follicular puncture

Abstract

The article was discussed the efficacy of treatment dose of progesterone Luteina in the dose 400 gr a day intravaginal in patients with tuboperitoneal factor of infertility. In patients with tuboperitoneal infertility in IVF who received a progesterone in the day of the trigger of the ovulation was diagnosed the increase in pregnancy rate compared to patients who received a progesterone in the day of the puncture of follicles. In particular there has been an increase in the frequency of child bearing in the patients who received progesterone in the day of the puncture of follicles.

The purpose of study was evaluating the effectiveness of therapeutic regimens of progesterone prescription in IVF programs by examining pregnancy, analysis of its course and outcomes in women with tubal-peritoneal factor of infertility.

A comparative analysis of pregnancy rate and the flow through the clinical, biochemical and instrumental methods of research in cycles of stimulation in women of reproductive age with tuboperitoneal infertility depending of the start of progesterone injections.

It is proved that in patients with injection of progesterone on the day of trigger of ovulation were no statistically significant differences in rates of pregnancy and implantation compared with patients whom progesterone was injected on the day of follicular puncture. However, there was a statistically significant difference in the number of clinical pregnancy, and multiple pregnancy in a subgroup of women which started using progesterone on the day of trigger of ovulation.

In the study of problem of treatment of tuboperitoneal infertility by exploring therapeutic regimens of progesterone prescription in stimulated IVF cycles were found that using of progesterone on the day of trigger of ovulation contributes to a full invasion of trophoblast and qualitative implantation that defines a successful outcome of pregnancy.

Author Biographies

О. В. Булавенко, Vinnytsya National Pirogov Memorial Medical University

MD, professor, head of Obstetrics and Gynecology Department number 2

І. Ю. Коцюбська, Vinnytsya National Pirogov Memorial Medical University

Obstetrics and Gynecology Department number 2

References

Bessmertnaya, V.S. Morphological and immunohistochemical characteristics of the endometrium in infertility: Thesis abstract for PhD degree, specialty 14.00.15. Moscow (2009): 28 p.
Giulmamedova, I.D., Mezhova, O.K. “Problems of implantation in IVF program: a literature review.” News of medicine and pharmacy. Gynecology 253 (2008): 17–27.
Karmyzova, T.S. Optimization of embryo transfer stage into the uterine cavity in IVF programs: Thesis abstract for МD degree, specialty 14.00.01. Moscow (2008): 21 p.
Kellet, E.P., Shurshalina, A.B., Korneeva, E.I. “The role of endometrium in failure of reproductive function realization (a literature review).” Problems of reproduction 2 (2010): 31–35.
Nazarenko, T.A. Durinyan, E.R., Perminova, S.G. “Current approaches to diagnosis and treatment of women infertility.” Gynecology 6.6 (2004): 323–5.
Nazarenko, T.A. Stimulation of ovarian function. 3-rd ed. Moscow. MEDpress-Inform (2011): 271 p.
Ozerskaya, I.A. Sonography in gynecology. Moscow. Vidar-M (2013): 564 p.
Olkhovskaya, M.A. “Biomarkers of «implantation window»: a literature review.” Problems of reproduction 13.1 (2007): 72–7.
Rudakova, E.B., Besman, I.V. “Assisted reproductive technologies. Problems of pregnancy loss.” Treating doctor 3 (2010): 46–8.
Svetlakov, A.V., et al. “The probability of occurrence of implantation in women with different forms of infertility in the treatment with IVF.” Problems of reproduction 8.3 (2002): 61–7.
Bulletti, C. “Targeted drug delivery in gynaecology: the first uterine pass effect.” Human Reproduction 12 (1997): 1073–9.
Сsapo, A.l. “Effects of luteectomy and progesterone replacement therapy in early pregnant patients.” Am J Obstet Gyn 115 (1973): 759–65.
Cicinelli, E., Schonauer, L. “Mechanism of uterine specificity of vaginal progesterone.” Hum Reprod 15.1 (2000:159–65.
Penzias, A.S. “Luteal phase support.” Fertil Steril 77 (2002): 318–23.
Wolf, A., Batzer, F.R. “Patient satisfaction with the use of Crinone in women undergoing assisted reproductive technology (ART).” Fertil Steril 70.1 (1998): 36–7.