Clinical effectiveness of therapeutic regimens of progesterone in IVF programs in women with tuboperitoneal factor of infertility

О. В. Булавенко, І. Ю. Коцюбська

Abstract


The article was discussed the efficacy of treatment dose of progesterone Luteina in the dose 400 gr a day intravaginal in patients with tuboperitoneal factor of infertility. In patients with tuboperitoneal infertility in IVF who received a progesterone in the day of the trigger of the ovulation was diagnosed the increase in pregnancy rate compared to patients who received a progesterone in the day of the puncture of follicles. In particular there has been an increase in the frequency of child bearing in the patients who received progesterone in the day of the puncture of follicles.

The purpose of study was evaluating the effectiveness of therapeutic regimens of progesterone prescription in IVF programs by examining pregnancy, analysis of its course and outcomes in women with tubal-peritoneal factor of infertility.

A comparative analysis of pregnancy rate and the flow through the clinical, biochemical and instrumental methods of research in cycles of stimulation in women of reproductive age with tuboperitoneal infertility depending of the start of progesterone injections.

It is proved that in patients with injection of progesterone on the day of trigger of ovulation were no statistically significant differences in rates of pregnancy and implantation compared with patients whom progesterone was injected on the day of follicular puncture. However, there was a statistically significant difference in the number of clinical pregnancy, and multiple pregnancy in a subgroup of women which started using progesterone on the day of trigger of ovulation.

In the study of problem of treatment of tuboperitoneal infertility by exploring therapeutic regimens of progesterone prescription in stimulated IVF cycles were found that using of progesterone on the day of trigger of ovulation contributes to a full invasion of trophoblast and qualitative implantation that defines a successful outcome of pregnancy.


Keywords


tuboperitoneal infertility; progesterone; IVF cycles; trigger of ovulation; follicular puncture

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DOI: https://doi.org/10.18370/2309-4117.2016.32.64-68

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