Modern aspects of the microbial landscape of the vagina and humoral immune response in women with chlamydia-viral cervicovaginitis. Correction of violations

Бу Вейвей, В. О. Бенюк, В. Л. Дронова, О. А. Щерба, Т. В. Ковалюк

Abstract


Despite significant advances in gynecology, the frequency of sexually transmitted diseases continues to grow, accounting for 50–80% of the total number of gynecological diseases. The normal microflora of the genital tract, under certain conditions acquires pathogenic properties. Chlamydia and herpes are among the most common human infections.

The article deals with modern aspects of vaginal microbiocenosis and its correction in patients with chlamydial-viral infection of the lower genital tract. The purpose of the study was to assess the state of vaginal microbiocenosis in women with chlamydia-viral cervicovaginitis, and reduce the frequency of relapses through the use of combination therapy.

Authors of study examined 67 women with recurrent chlamydia-herpes cervicovaginitis, which were divided into 2 groups: I – 35 patients receiving the proposed treatment; II (comparison group) and 32 patients receiving traditional therapy. Therapy efficacy was evaluated during treatment and 1, 3, 6 months after. The examination included anamnestic, clinical, laboratory, bacteriological, bacteriological, immunological studies, ELISA and PCR.

In the results of clinical trials was proven clinical effectiveness of a comprehensive anti-inflammatory treatment of patients with recurrent cervicovaginitis. It is established that complex treatment with valacyclovir, azithromycin and tiloron and local solution of benzydamine for douching reduces treatment time and reduces the number of relapses. In particular, from women in group I who received the combined therapy, the complaints disappeared through 2–3 days, whereas in group II decrease itching and discomfort was noted only through 5–6 days. In addition, 88.6% of patients in group I noted the absence of side effects and bacterial eradication at the follow-up surveys.

As study authors conclude, patients with chlamydia-herpeticum cervicovaginitis have a violation of the vaginal biocenosis. Conducted comprehensive therapy is effective, leads to increase of parameters of nonspecific resistance of the organism, which contributes to the normalization of vaginal microbiocenosis.


Keywords


microbiocenosis of the vagina; chlamydia; genital herpes; treatment

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DOI: https://doi.org/10.18370/2309-4117.2016.32.46-49

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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)