Abnormal uterine bleeding





clinical case, abnormal uterine bleeding, failure of the mitral valve, tranexamic acid, Vidanol, diclofenac sodium, Ferinzhekt, Maltofer


The article describes a clinical case of severe uterine bleeding in a patient with III degree of mitral valve insufficiency after mitral valve replacement, which was placed a clinical diagnosis of abnormal uterine bleeding (AUB). Given the categorical refusal of the patient and her relatives from holding hysteroscopy the conservative haemostatic therapy was appointed.

In view of the congenital heart disease and the risks of thrombotic complications the oral contraceptive for patient was contraindicated. Therefore, for the treatment was selected the drug of tranexamic acid Vidanol at dose of 1.5 g every 8 hours for 5 days, as well as non-steroidal anti-inflammatory drug diclofenac sodium in rectal suppositories of 100 mg over 5 days. Considering the moderate secondary anemia and the severity of clinical symptoms, for patient was also appointed anti-anemia drug Ferinzhekt at a dose of 1000 mg intravenously once, followed by the appointment after 1 week Maltofer on 1 tablet 3 times a day for a month.

During the first 12 hours of treatment with the combination Vidanol +diclofenac sodium was observed a decrease in the volume of blood loss of patient, the decrease of intensity of pain, and improvement in overall condition. Against the background stabilization of the general condition of the patient under ultrasound was performed the dissection and separation of intrauterine adhesions, which were detected during diagnostic hysteroscopy. In order to prevent recurrence of occurrence of this disease was introduced anti-adhesion gel Defensal in the uterus. Postoperatively, the patient also received antibiotic prophylaxis and complex of anti-inflammatory therapy.

In the next two menstrual cycles in order to prevent of AUB the patient took from 1 to 5 day of menstruation on 500 mg of Vidanol 3 times a day, as well as suppositories diclofenac sodium one day before the onset of menstruation and within 5 days of the cycle. After 2 months at the time of the next menstruation for woman was set intrauterine system (IUS), which releasing daily 13.5 mg of levonorgestrel. At the control examination 3 months after IUS installation the patient was no complaints, no bleedings and pain, and her general condition was improved.

This clinical case is an example of an effective and safe treatment for severe AUB for patient of reproductive age with severe somatic pathology. Appointment of tranexamic acid in combination with nonsteroidal anti-inflammatory drugs and anti-anemia therapy is effective in the treatment of AUB and can be used for the prevention of uterine bleeding.

Author Biographies

Т. Ф Татарчук, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

MD, professor, corresponding member of the NAMS of Ukraine, deputy director for research work, сhief of the Endocrine Gynecology Department

Н. В. Косей, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

MD, chief researcher at the Endocrine Gynecology Department

О. В. Занько, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

Postgraduate student at the Endocrine Gynecology Department

Н. В. Яроцька, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

Junior researcher at the Endocrine Gynecology Department


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How to Cite

Татарчук, Т. Ф., Косей, Н. В., Занько, О. В., & Яроцька, Н. В. (2016). Abnormal uterine bleeding. REPRODUCTIVE ENDOCRINOLOGY, (31), 103–106. https://doi.org/10.18370/2309-4117.2016.31.103-106



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