Assessment of the effectiveness of targeted therapy in women with hyperplastic gynecological syndrome and comorbid diseases

С. О. Шурпяк

Abstract


In the structure of general gynaecological morbidity a leading place is occupied by combined benign proliferative diseases of the reproductive system, which are considered by number of authors as a “hyperplastic gynecological syndrome”. The global effects on receptor apparatus of the entire reproductive system causes many common gynecological diseases (uterine fibroids, endometriosis, endometrial hyperplasia) and benign breast diseases as hormone-receptor tissue simultaneously respond to adverse irritants. Stress, immune disorders, infectious diseases, structural and functional disorders of the thyroid gland can initiate imbalance of the hypothalamic-pituitary-ovarian system. The lack of thyroid hormone affects almost all processes of life, as their impact is realized on the cellular and molecular levels, of all organs and body systems.

Were conducted a study evaluating the effectiveness of a 6-month target therapy by Epihalin Brest in the complex treatment of patients with combined benign proliferative diseases of reproductive organs and comorbid disorders (subclinical hypothyroidism, excessive body weight).

The criteria for the effectiveness of therapy by dynamics of reduction of clinical symptoms, normalization of hormonal homeostasis condition of the endometrium and breast. Combined therapy of this category of patients as a result of synergies medicinal components (Epihalin Brest, vaginal micronized progesterone, levothyroxine) allowed to reach full clinical and laboratory effects in 98.0% of women, while maintaining in the comparison group (therapy without Epihalin Brest) menstrual disorders in 10% cyclic mastalgia and mastodynia in 43.3% of patients.

The positive effect of Epihalin Brest in case of combined dishormonal proliferative processes of reproductive organs on the background of comorbid pathology based on multifocal influences withe universal anti-estrogenic and anti-proliferative effects which eliminate the state of relative and absolute hyper-oestrogens, reduce local inflammation in target organs, improve or restore fully hierarchical mechanisms of hormonal regulation of the menstrual cycle and trophic receptor apparatus and target organs and thyroid. Post-therapeutic positive effect of Epihalin Brest confirmed the absence of recurrence of clinical manifestations in 96.0% of patients and high occurrence of desired pregnancies.


Keywords


targeted therapy, Epihalin Brest, subclinical hypothyroidism, combined benign proliferative disease of the reproductive system, comorbid conditions

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16. Kondo, T., Ohta, T., Igura, K., et al. “Tea catechins inhibit angiogenesis in vitro, measured by human endothelial cell growth, migration and tube formation, through inhibition of VEGF receptor binding.” Int J Cancer 180.2 (2002): 139–44.

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DOI: http://dx.doi.org/10.18370/2309-4117.2016.31.90-96

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