Features of hormonal homeostasis in pregnant women with functional disorders of the cervix obstructive function
Keywords:violation of cervix obstructive function, miscarriage, placental hormones, stress-induced hormones, undifferentiated connective tissue dysplasia
Women with the undifferentiated connective tissue dysplasia and violation of the cervix obstructive function during pregnancy form a considerable part of the contingent of pregnant women that in the case of extremely early premature birth forming the perinatal morbidity and mortality rates. The steady increase in the number of first time pregnant and nulliparous with this disease in a population of pregnant women indicates the presence disorders of hormonal homeostasis in these women. Consequently, clear visions about a hormonal homeostasis state of such pregnant women are needed for the prioritizing of antenatal surveillance programs.
Authors have conducted a dynamic prospective (22–23 and 32–33 weeks) study of 63 pregnant women with violation of the cervix obstructive functions (main group) and 34 pregnant women with physiological pregnancy (control group). The concentrations of the most influential hormones on the pregnancy course, such as placental hormones (estradiol, progesterone), pituitary gland (prolactin) and adrenal gland (cortisol) have been studied by the usage of ELISA in pregnant women of the survey samples.
The results of the research has been shown that there is a placental dysfunction in the pregnant women of the main group that is manifested by instability of the placental hormones biosynthesis, delayed increase in the progesterone concentration in the dynamics of pregnancy, mean concentrations of which were within lower limit of physiological normal state and were significantly lower than in pregnant women of the control group. So this leads to a shift in the estrogen and progesterone balance in the direction of relative hypoprogesteronemia, which is the main link of manifestation pathogenesis of the functional cervical incompetence. At the same time in pregnant women of the main group in blood serum was noticed a significant increase of concentrations of stress-induced hormones, such as cortisol and prolactin, hyperproduction of which is accompanied by the hyper tonus and development of premature uterine activity.
Thus, the placental dysfunction and increased production of stress-induced hormones of the pituitary and adrenal glands are typical for the pregnant women with violation of the functional cervical incompetence. For correction of the hormonal homeostasis disorders that were found in such pregnant women is advisable to use natural progesterone with evident neurotropic and anxiolytic properties.
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Copyright (c) 2016 І. А. Жабченко, В. Ф. Олешко, О. М. Бондаренко, О. Р. Сюдмак
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