Stress infertility




stress, infertility, anxiety, Cyclodynon


In order to optimize the treatment of the primary stress-induced infertility the authors evaluated the effectiveness of complex therapy aimed at correcting the mental and emotional state, and the secondary hyperprolactinemia in 72 patients aged 24 to 40 years old with reproductive plans (38 women from the main group and 34 – the comparison group). The control group consisted of 30 healthy women.

Research of hormonal homeostasis of patients before treatment was showed a decrease in the average level of the pituitary hormones, low average concentrations of estradiol and progesterone, moderately elevated level of prolactin, and reduced indicators of endometrial thickness. The vast majority of women were in a heightened state of reactive and personal anxiety.

All of study participants received anti-stress therapy (phenibut + mebicar). In addition, the main group on the background of anti-stress treatment received the drug Cyclodynon, which has a mild dopaminergic action, contributing to inhibition of prolactin secretion and normalize the function of the hypothalamic-pituitary-ovarian system.

Within 3 months after the start of a complex anti-stress therapy in both groups the level of reactive anxiety was reduced, and the level of personal anxiety was reduced a lesser extent.

Dynamic control of hormones showed a significant decrease in the average concentrations of prolactin and increase of the synthesis of follicle-stimulating, luteinizing hormone, estradiol and progesterone in the blood serum of a group of women receiving Cyclodynon. In that group also was observed a significantly reduction the average concentration of prolactin and increased endometrial thickness. In the comparison group, which applied only anti-stress therapy, a similar trend was observed, but the full normalization not happened.

Within three years after treatment the pregnancy occurred in 32 (94.11%) women of the main group, and only 17 (50%) – of the comparison group.

The conclusion of research results: the combination of anti-stress and dopaminergic therapies is very effective. Consequently, it is possible to recommend assignment dopaminergic phytodrugs (in particular Cyclodynon) on background of anti-stress therapy for patients with stress-induced infertility with a view to correction of psychosomatic disorders and improvement of clinical pregnancy rates.

Author Biographies

Н. В. Косей, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

MD, chief researcher at the Endocrine Gynecology Department

С. И. Регеда, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

Senior researcher at the Endocrine Gynecology Department

Н. В. Яроцкая, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

Junior researcher at the Endocrine Gynecology Department

А. А. Горохова, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

Doctor-intern at the Endocrine Gynecology Department


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How to Cite

Косей, Н. В., Регеда, С. И., Яроцкая, Н. В., & Горохова, А. А. (2016). Stress infertility. REPRODUCTIVE ENDOCRINOLOGY, (31), 12–21.