Hormonal homeostasis in women with infertility and functional disorders of hepatobiliary system

В. В. Камінський, В. В. Суменко, Т. В. Коломійченко, О. Г. Бойчук

Abstract


Hormonal disorders are not related only with reproductive pathology, but also affect the function of many organs and systems. The most frequently disorders is liver metabolic dysfunction. The pathologic basis for this is hypothalamic-pituitary-ovarian-liver metabolic system. For example, in women with infertility is often identified liver and biliary tract diseases, leading to the estrogen metabolism disorders, on the other – an excess in the blood of some sex steroids adversely affect the various liver functions.

The close relationship of the liver function and the level of female sex hormones, the combination of their disorders, as well as use in the treatment of infertility hormone therapy that adversely affects the function of the liver, explains the need to examine the state of hormonal homeostasis in women with infertility and the hepatobiliary system diseases.

Studied 120 women with infertility, among them 60 women with functional disorders of the hepatobiliary system (the first group), 60 women with no evidence of such disorder included in the second group. Luteinizing hormone, follicle stimulating hormone, prolactin, free testosterone, estradiol and progesterone in the serum were determined by radioimmunological method during menstrual cycle. Hormonal colpocytologic study conducted by the usual method (Pap-smear in A.V. Rudenko modification on the 7th, 14th and 21st day of the menstrual cycle).

Imbalance of gonadotropin hormones, pointing to progesterone deficiency, hyperestrogenemia, hyperandrogenemia and hyperprolactinemia symptoms were identified in the study of hormonal status on the level of hormones in the blood serum in women with infertility and hepatobiliary system diseases. Hormonal changes confirmed by colpocytologic study of vaginal secretions. Anovulatory menstrual cycle on hyperestrogenia type was diagnosed in 56.7% women with infertility and hepatobiliary pathology versus 41.7% of women without functional disorders of hepatobiliary system (p < 0,05).

These results are the theoretical basis for inclusion drugs that improve the liver function in the complex therapy of women with infertility and hepatobiliary pathology.


Keywords


infertility; hepatobiliary system; steroid hormones; colpocytology

References


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DOI: http://dx.doi.org/10.18370/2309-4117.2016.31.8-11

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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)