Nonhormonal therapy of climacteric disorders




climacteric syndrome, non-hormonal therapy, Klimaktoplan, Valesan


The aim of the study was to optimize the treatment of climacteric disorders, taking into account the nature of psychopathological disorders. 100 women 50–55 years old with climacteric disorders of mild to moderate severity were examined. Depending on the treatment women were divided into 3 groups: I group – 30 women received a complex homeopathic medication Klimaktoplan within 3 months, group II – 34 women received monotherapy with Valesan for 3 months, III group – 36 patients received both these drugs during the same period.

Assessment of the severity of climacteric syndrome was held in accordance with the Menopausal Rating Scale (MRS) before and after treatment. To assess the level of anxiety used Spielberger-Hanin questionnaire. To identify insomnia disorders was used questionnaire of scoring assay for subjective sleep characteristics proposed by Y.I. Levin.

Study of climacteric manifestations showed that the average total MRS scale score decreased in all groups after treatment. However, the best results were demonstrated in patients group III. Against the background of neuro-vegetative disorders reduction and improve sleep parameters was significantly reduced physical and mental exhaustion.

Monitoring the frequency and nature of personal anxiety during therapy showed statistically significant decreasing proportion of patients with high and low levels in all groups and increasing the number of women with a moderate level. The largest share of women with secondary (optimal) level of personal anxiety was observed in group III, which was administered Klimaktoplan and Valesan. Also, in all groups patients significantly reduced the severity of sleep disorders, but the most in group III.

Study results indicate the feasibility complex use of Klimaktoplan and Valesan for climacteric syndrome treatment. Complex use these drugs results in improved sleep, reduced anxiety levels, causes a decrease in hot flushes number and improve the quality of women life.

Author Biographies

Т. Ф Татарчук, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

MD, professor, corresponding member of the NAMS of Ukraine, deputy director for research work, chief of the Endocrine Gynecology Department

О. О. Єфименко, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

PhD, senior researcher of the Endocrine Gynecology Department

О. В. Занько, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

Graduate student of the Endocrine Gynecology Department


  1. Freeman, E.W. “Depression in the menopause transition: risks in the changing hormone milieu as observed in the general population.” Women’s Midlife Health 1.2 (2015). DOI: 10.1186/s40695-015-0002-y
  2. Freeman, E.W., Sammel, M.D., Lin, H., et al. “Symptoms associated in menopause transition and reproductive hormones in mid-life women.” Obstet Gynecol 110 (2007): 230–40.
  3. Kravitz, H.M., Ganz, P.A., Bromberger, J., et al. “Sleep difficulty in women at midlife: a community survey of sleep and the menopausal transition.” Menopause 10.1 (2003): 19–28.
  4. Murphy, P.J., Campbell, S.S. “Sex hormones, sleep, and core body temperature in older postmenopausal women.” Sleep 30.12 (2007): 1788–94.
  5. Park, Y.K., Cha, N.H., Sok, S.R. “Relationships between menopausal syndrome and sleeping of middle-aged women.” Journal of Physical Therapy Science 27.8 (2015): 2537–40.
  6. Scheider, H., Heinemann, L., Rosemeir, H., et al. “The menopause rating scale (mrS): reliability of scores of menopausal compleants.” Climacteric 3 (2000): 59–64.
  7. Taavoni, S., Ekbatani, N., Kashaniyan, M., Haghani, H. “Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial.” Menopause 18.9 (2011): 951–5.
  8. Vousoura, E., Spyropoulou, A., Koundi, K., et al. “Vasomotor and depression symptoms may be associated with different sleep disturbance patterns in postmenopausal women.” Menopause 22.10 (2015): 1053–57.
  9. Wuttke, W., Seidlova-Wuttke, D. “Black cohosh (Cimicifuga racemosa) is a non-estrogenic alternative to hormone replacement therapy.” Journal of Phytomedicine and Phytotherapy 1.12 (2015). DOI: 10.1186/s40816-015-0013-0
  10. National consensus on management patients in menopause. Reproductive endocrinology 1.27 (2016): 8–25.
  11. Madaeva, I.M., Kolesnikova, L.I., Solodova, E.I., Semenova, N.V. “Climacteric syndrome and sleep disorders.” FSBU “Scientific Center of Family Health Problems and Human Reproduction” SB RAMS (Irkutsk) 2.84 (2012).
  12. Scales, tests and questionnaires in medical rehabilitation. Ed. by V.N. Belova, O.N. Shchepetova. Moscow (2002): 67–97.
  13. Poluektov, M.G. “Clinical algorithm for diagnostic and treatment choice for insomnia.” Effective Pharmacotherapy. Neurology and Psychiatry 12 (2013).
  14. Tatarchuk, T.F., Yefymenko, O.A., Islamova, A.O. “Climacteric syndrome as a clinical manifestation of perimenopause.” Reproductive endocrinology 1.21 (2015).
  15. Tatarchuk, T.F., Yefymenko, O.A., Islamova A.O. “Menopause: A new look at an old problem.” Reproductive endocrinology 1 (2013).
  16. Richardson, T., Robinson, R. “Menopause and depression: a review of psychologic function and sex steroid neurobiology during the menopause.” Obstet Gynecol 7 (2000): 215–23.
  17. Bixler, E., Vgontzas, A., Lin, H., et al. “Prevalence of sleep-disordered breathing in women.” Am J Respir Crit Care Med 163 (2001): 608–13.



How to Cite

Татарчук, Т. Ф., Єфименко, О. О., & Занько, О. В. (2016). Nonhormonal therapy of climacteric disorders. REPRODUCTIVE ENDOCRINOLOGY, (30), 75–80.



Management of menopause