The possibility of using mastodynon after endoprosthetics of mammary glands

Authors

  • Л. С. Сотникова Siberian State Medical University of the Ministry of Health of Russian Federation; ISPE “Women’s Health”, Tomsk, Russian Federation
  • А. А. Сотников Siberian State Medical University of the Ministry of Health of Russian Federation, Tomsk
  • Е. В. Удут Federal state budgetary institution “Scientific Research Institute of Pharmacology”, Tomsk, Russian Federation
  • О. С. Тонких “International Institute of Biological Systems – Tomsk” Ltd, Tomsk, Russian Federation

DOI:

https://doi.org/10.18370/2309-4117.2016.29.94-99

Keywords:

benign breast diseases, breast endoprosthetics, mathematical model, Mastodynon®

Abstract

The study to evaluate the efficacy of the drug Mastodynon® in treatment of benign mammary dysplasia after endoprosthetics was performed. Presented effective quality mathematical model of diagnostics and monitoring of dyshormonal breast pathology treatment, also after endoprosthetics of mammary glands.

During the period from 2009 to 2013 85 women of reproductive age before and after the endoprosthetics of the mammary glands were included in the study. A clinical study (phase IV) was a prospective, randomized, and monocenter. A study group comprised 58 patients with a diagnosis of “diffuse dyshormonal mammary dysplasia.” Effectiveness of Mastodynon® treatment for this disease was evaluated with the use of diagnostic mathematical model. In 33 patients of the main group Mastodynon® used for treatment for 12 weeks and up to 6 months for further follow-up. The control group include 25 women from the main group who did not receive conservative treatment. The control group consisted of 27 healthy women, comparable with the main group for age, without somatic, breast and gynecological pathologies.

Obtained decision rules in the diagnostic tables provide quality recognition in 87–94% of cases, which allows based on the developed by the authors mathematical model to objectively diagnose and assess the effectiveness of the dyshormonal breast pathology therapy.

The results showed high efficiency of Mastodynon® treatment of benign diffuse dyshormonal breast dysplasia for 3 months in women after total endoprosthetics. Criteria for evaluating of the effectiveness were not only clinical symptoms but also objective echographic indicators (thickness of premammary tissue, fibroglandulyar layer and retromammary tissue).

The study also significantly showed that the lack of treatment in women with dyshormonal breast pathology after endoprosthetics leads to an unfavorable progression of the main signs of clinical and sonographic characteristics of the disease.

Author Biographies

Л. С. Сотникова, Siberian State Medical University of the Ministry of Health of Russian Federation; ISPE “Women’s Health”, Tomsk, Russian Federation

MD, professor at the Obstetrics and Gynecology Department; head

А. А. Сотников, Siberian State Medical University of the Ministry of Health of Russian Federation, Tomsk

MD, professor at the Department of Plastic Surgery with a Course of Operative Surgery and Topographic Anatomy

Е. В. Удут, Federal state budgetary institution “Scientific Research Institute of Pharmacology”, Tomsk, Russian Federation

MD, professor, leading researcher, Laboratory of Pathological Physiology and Experimental Medicine

О. С. Тонких, “International Institute of Biological Systems – Tomsk” Ltd, Tomsk, Russian Federation

PhD, roentgenologist

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Published

2016-07-15

Issue

Section

Drug therapy