Features of menopausal syndrome treatment in women with endometriosis


  • Н. Ф. Захаренко Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine, Ukraine
  • Н. В. Коваленко Kyiv City Hospital number 9, Ukraine
  • Т. Ф. Татарчук SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”, Ukraine https://orcid.org/0000-0002-5498-4143




menopause, endometriosis, anti-stress therapy, noofen, adaptol


Correction of menopausal disorders on the endometriosis background has certain specificity, due to the fact that the menopausal hormone therapy in this group of women is extremely limited because of the possible endometriosis manifestations, which requires the development of new integrated scheme of nonhormonal therapy. Given the major impact of chronic stress in the mechanism of the endometriosis development and menopausal syndrome, authors found it necessary to use the anti-stress therapy for the treatment of this pathology. Authors had developed a treatment regimen without menopausal hormone therapy for women with mild to moderate climacteric syndrome and with history of endometriosis. Noofen was selected like the main drug as a stabilizer cognitive disorders and antihypoxant, as additional drug was used anxiolytic adaptol.

60 women with climacteric syndrome of mild to moderate severity and with history of endometriosis received treatment during the 6 weeks, which were divided into two groups of 30 women: the first group received monotherapy with noofen, women in the second group received the combined therapy that included adaptol and noofen.

Evaluation of the clinical status of patients and severity of menopausal disorders was conducted on a Menopause Rating Scale (MRS). The level of anxiety was measured on a Spielberg scale. Changing the assessment of life quality during therapy was determined by questionnaire Freiburg Personality Inventory (FPI).

The therapy result showed a significant improvement in the evaluated parameters in patients of both groups. In second group of women already in the first two weeks after complex therapy the improvements were found in comparison with the group receiving monotherapy. Thus, the chosen regimen helps to quickly eliminate the climacteric syndrome in women with endometriosis, improve and stabilize their psychological profile, recover, improve and adapt the quality of life.

Author Biographies

Н. Ф. Захаренко, Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine

MD, chief researcher at the Endocrine Gynecology Department

Н. В. Коваленко, Kyiv City Hospital number 9

Obstetrician-gynecologist of the Gynecological Department

Т. Ф. Татарчук, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

MD, professor, corresponding member of NAMS of Ukraine, deputy director for research work, Chief of the Endocrine Gynecology Department


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How to Cite

Захаренко, Н. Ф., Коваленко, Н. В., & Татарчук, Т. Ф. (2016). Features of menopausal syndrome treatment in women with endometriosis. REPRODUCTIVE ENDOCRINOLOGY, (29), 60–66. https://doi.org/10.18370/2309-4117.2016.29.60-66



Management of menopause