Composition of lectin receptors in serous and mucinous ovarian cystadenomas
Keywords:serous cystadenoma, mucinous cystadenoma, lectins, glycoconjugates, proliferation
The most common group of benign cystic ovarian tumors in women of all ages are epithelial tumors (cystadenomas) that make up about a third of ovarian tumors and half of benign lesions.
The growth of tumor proliferative activity accompanied by increased number of lectins receptors in cells. Lectins are non-immune origin proteins that have a common property of binding carbohydrates and carbohydrate determinants of biopolymers strictly defined structure and intact their covalent structure. It was established that oncogenesis changes of the structure of glycoconjugates membrane as cancer and immune cells, and mark faster than glycoconjugates variability in tumor cells. This is the basis for the use of labeled lectins to study changes in cell membrane and secretory structures of glycoconjugates during tumor growth.
The aim of the study was to determine the composition of the receptors in serous and mucinous cystadenomas.
Operating material was studied from 60 women operated on for ovarian serous cystadenomas, and from 60 patients – on for ovarian mucinous cystadenomas. To identify the set of glycoconjugates it were used peroxidaselabeled lectins with different carbohydrate specificity.
Characteristic of serous and mucinous cystadenomas was the accumulation of lectins receptors in their cells of wheat germs (WGA), groundnut seed (PNA) and soybean seeds (SBA). Papillary serous cystadenomas differed moderate accumulation in the epithelium papillae throughout the cytoplasm lectins receptors of SBA, mistletoe (VAL) and WGA. The most intense and uniform expression in mucinous cystadenomas was one of lectin receptors of bark elderberry (SNA) and SBA.
The authors conclude that changes in the molecular-spatial structure of glycoconjugates of the plasmolemma cells surfaces and increase of the mobility of membrane lectins receptors in serous and mucinous cystadenomas cause lack of contact inhibition of proliferation. In their opinion, further study of lectins can contribute to the elucidation of the pathogenesis of ovarian formations, their differential diagnosis, the development of tumor markers and drugs lectins.
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