DOI: https://doi.org/10.18370/2309-4117.2016.28.60-67

Treatment features of pelvic inflammatory diseases in women with polycystic ovary syndrome

Н. В. Косей, Т. О. Лісяна, Г. В. Ветох

Abstract


Polycystic ovary syndrome (PCOS) is a common disease with frequency of 6 to 20% depending on the criteria used. Combined PCOS with pelvic inflammatory diseases (PID) lead to multicomponent damage of the reproductive system.

The aim of the study was the development of pathogenetic therapeutic algorithm for patients with PCOS on the background of PID-based study of the relations between the functioning of the pituitary-ovarian system and the flow characteristics of the inflammatory process. Medical complex consisted of antibiotic therapy, antifungal drugs, as well as glutoxim, normocycle, noofen, api-norm, polygynax.

49 patients with PCOS against the backdrop of PID (the main group) were treated according to the developed scheme. The comparison group consisted of 31 women who underwent only standard antibacterial and antifungal therapy.

After treatment in the main group was more marked decrease in the frequency of complaints of aching pain in the lower abdomen. Regular menstrual cycle is established in 59.2%of women of the main group, which was significantly higher than in comparison group – 22.6% of the patients. Combined therapy helped restore steroid production by ovarian, which manifested in increase the estrogen and progesterone synthesis, and was accompanied by a decrease in androgen level. Bacterioscopic study after treatment in both groups showed a decrease in the proportion of III and IV degrees of vaginal cleanliness and increase of II degree. In the main group after treatment the proportion of I and II degrees almost 2 times was higher than in the comparison group.

Studies have shown that the use of the developed treatment helps to eliminate the symptoms of inflammation, reduction of contamination of the genital tract by pathogenic and opportunistic microflora, improve vascularity and ovarian function which was manifested in ovulatory cycles increasing from 14.3% to 73.5% with normalization of hormonal homeostasis.


Keywords


polycystic ovarian syndrome; pelvic inflammatory diseases

References


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GOST Style Citations


1. Ehrmann, D. “Polycystic ovary syndrome.” New England Journal of Medicine 352 (2005).

2. Калугина, Н.В. Опыт лечения синдрома поликистозных яичников / Н.В. Калугина, О.А. Ефименко // Репродуктивная ендокринология. – 2012. – №2 (4). – C. 74–78.

3. Katsikis, I., Karkanaki, A., Misichronis, G., et al. “Phenotypic expression, body mass index and insulin resistance in relation to LH levels in women with polycystic ovary syndrome.” Eur J Obstet Gynecol Reprod Biol 156 (2011):181–5.

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