Nonspecific vulvovaginitis of mixed etiology: local treatment – the treatment of choice
Keywords:nonspecific vaginitis, topical therapy, ternidazolum, tergynan
The article presents the comparative study of local therapy nonspecific vaginitis in 60 patients of reproductive age. The study included patients with a diagnosis of vulvovaginitis of mixed etiology confirmed according to clinical and laboratory diagnostic methods.
Participants were randomized into 2 equal groups of 30 women. Main group patients appointed tergynan vaginal tablets for 10 days for the night vaginally. The comparison group treated with combination drug (miconazolum + ornidazolum + neomycin + prednisolonum, in the form of vaginal tablets) for 8 days. Treatment of sexual partners in both groups was carried out in accordance with generally guidelines.
Analysis of the results of a comparative study showed greater efficacy of tergynan treatment.
Vulva itching of average severity stopped to disturb most women in both groups an average for the 4th day of treatment. In similar terms it was regression of the basic clinical symptoms in the vast majority (90.0%) main group patients, and in particular the disappearance of burning and odor. In the comparison group improvement comes after almost two days by storing complaints burning and pathological secretions almost to the 6th day of observation.
The results of bacteriological examination one month after therapy completion have confirmed the effectiveness of the treatment in the majority (90.0%) of women in main group and in 80.0% patients in control group.
The results allow to recommend the use of a 10-day course of combined drug tergynan (ternidazolum + nystatin + neomycin sulfate + prednisolone sodium metasulphobenzoate) as a more effective not only in the empirical, but local and causal therapy of vulvovaginitis mixed etiology.
The authors conclude that topical treatment for nonspecific vulvovaginitis is effective and safe, and can be considered as first-line therapy.
- Vdovichenko, Y.P., Gopchuk, E.N. “Tergynan in obstetric practice.” Women’s Health 10.66 (2011): 71–4.
- Gerasimova, T.V., Gopchuk, E.N. “Effective antibiotic therapy – modern aspects of the combined drugs use in gynecologist practice.” Women’s Health 6 (2012): 46–8.
- Dubossarskaya, Y.A., Dubossarskaya, Z.M. “Tergynan is a drug of choice in the treatment of bacterial vaginosis.” Women’s Health 6.72 (2012): 147–52.
- Infection in obstetrics and gynecology / Ed. by O.V. Makarov, V.A. Aleshkin, T.N. Savchenko. Moscow. MEDpress-Inform (2007): 177–89.
- Kira, E.F., Gaitukieva, R.A., Bezhenar, V.F., et al. “A multicenter, randomized, controlled comparative study of the efficacy and safety of drugs poligynaks and tergynan the treatment of nonspecific vaginitis.” Gynecology 11.1 (2009): 13–7.
- Kira, E.F., Muslimova, S.Z. “Non-specific vaginitis and its impact on women’s reproductive health (review).” Problems of Reproduction 5 (2008): 8–13.
- Kosei, N.V., Tatarchuk, T.F., Vetokh, G.V. “Empirical therapy of vaginitis as a method for prevention of ascending infection.” Reproductive Endocrinology 2.4 (2012): 70–3.
- Kogan, B.G., Gordeeva, G.D. “Role of combined antibiotics in treatment of mixed etiology pelvic inflammatory diseases.” Women’s Health 5.91 (2014): 86–90.
- Mamchur, V.I., Dronov, S.N. “Tergynan at pharmacology eyes: an innovative approach to the treatment of various origin vaginitis.” Medical Aspects of Women’s Health 9.95 (2015).
- Moroz, V.A. “Pharmacological aspects of the combined antimicrobial agents in the treatment of female genital infections.” Dermatology. Cosmetology. Sexual pathology 1–2 (2010): 184–91.
- Radzinskyi, V.E. “Urogenital tract microbiocenosis correction.” Pharmacotherapy in Obstetrics and Gynecology 4 (2009): 44–6.
- Romashchenko, O.V., Lebed, L.A., Yakovenko, L.F., et al. “Approaches reassessment to the diagnosis and treatment of genitals inflammatory diseases caused by mixed infection.” Women’s Health 5 (2009): 161–8.
- Donders, G. , Ruban, К., Bellen, G. “Selecting Anti-Microbial Treatment of Aerobic Vaginitis.” Current Infectious Disease Reports 17.5 (2015): 477. DOI: 10.1007/s11908-015-0477-6.
- Fan, A., Yue, Y., Geng, N., Zhang, H. “Aerobic vaginitis and mixed infections: comparison of clinical and laboratory findings.” General Gynecology 287.2 (2013): 329–35.
- Workowski, K.A., Berman, S. “Sexually transmitted diseases treatment guidelines.” MMWR Recomm Rep 59 (2010): 101–10.
How to Cite
Copyright (c) 2016 Л. В. Калугина, Т. Ф. Татарчук, И. Н. Шакало, Д. Г. Герман
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.