Nonspecific vulvovaginitis of mixed etiology: local treatment – the treatment of choice




nonspecific vaginitis, topical therapy, ternidazolum, tergynan


The article presents the comparative study of local therapy nonspecific vaginitis in 60 patients of reproductive age. The study included patients with a diagnosis of vulvovaginitis of mixed etiology confirmed according to clinical and laboratory diagnostic methods.

Participants were randomized into 2 equal groups of 30 women. Main group patients appointed tergynan vaginal tablets for 10 days for the night vaginally. The comparison group treated with combination drug (miconazolum + ornidazolum + neomycin + prednisolonum, in the form of vaginal tablets) for 8 days. Treatment of sexual partners in both groups was carried out in accordance with generally guidelines.

Analysis of the results of a comparative study showed greater efficacy of tergynan treatment.

Vulva itching of average severity stopped to disturb most women in both groups an average for the 4th day of treatment. In similar terms it was regression of the basic clinical symptoms in the vast majority (90.0%) main group patients, and in particular the disappearance of burning and odor. In the comparison group improvement comes after almost two days by storing complaints burning and pathological secretions almost to the 6th day of observation.

The results of bacteriological examination one month after therapy completion have confirmed the effectiveness of the treatment in the majority (90.0%) of women in main group and in 80.0% patients in control group.

The results allow to recommend the use of a 10-day course of combined drug tergynan (ternidazolum + nystatin + neomycin sulfate + prednisolone sodium metasulphobenzoate) as a more effective not only in the empirical, but local and causal therapy of vulvovaginitis mixed etiology.

The authors conclude that topical treatment for nonspecific vulvovaginitis is effective and safe, and can be considered as first-line therapy.

Author Biographies

Л. В. Калугина, SI “Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine“

MD, leading researcher at the Endocrine Gynecology Department

Т. Ф. Татарчук, SI “Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine“

MD, professor, corresponding member of the NAMS of Ukraine, deputy director for research work, Сhief of the Endocrine Gynecology Department

И. Н. Шакало, SI “Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine“

PhD, junior researcher at the Endocrine Gynecology Department

Д. Г. Герман, SI “Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine“

Postgraduate student at the Endocrine Gynecology Department


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How to Cite

Калугина, Л. В., Татарчук, Т. Ф., Шакало, И. Н., & Герман, Д. Г. (2016). Nonspecific vulvovaginitis of mixed etiology: local treatment – the treatment of choice. REPRODUCTIVE ENDOCRINOLOGY, (27), 94–100.



Inflammatory diseases