Nitrosative status in benign epithelial cystic ovarian tumors of nonendometrioid origin

Authors

DOI:

https://doi.org/10.18370/2309-4117.2016.27.78-82

Keywords:

nitrosative status, cystic ovarian tumors of nonendometrioid origin, NOx, iNOS, immunohistochemistry

Abstract

Ovarian tumors are in second place (6–8%) from of all the female genital tumors. Benign forms are found in 75–80% of true ovarian tumors. Despite the fairly detailed knowledge of ovarian tumors, causes of origin and benign tumors of ovarian cysts remain open. Several studies have shown the important role of NO in ovarian physiology. It was shown that NO is synthesized locally ovaries and may play a role in the development of follicles, ovulation and luteal formation. Data on changes in the content NO derived and NOS activity in benign ovarian tumor are absent.

The aim of the study was to investigate the characteristics of nitrosative status of benign epithelial cystic ovarian tumors of nonendometrioid origin. 220 patients of reproductive age were examined: 40 patients with ovarian follicular cysts, 60 – with serous cystadenomas, 60 – with mucinous cystadenomas, 30 – with cystadenocarcinomas of nonendometrioidnogo origin, 30 patients consist control group. NOx level of in the serum and in intracystic content, iNOS imunoreactivity in the walls of the remote masses were investigated.

Study of NOx levels in biological fluids revealed the likely reduction of serum neutral NO metabolites in the cystadenocarcinomas, serous and mucinous cystadenomas in comparison with follicular cysts and control. Differences of intracystic NOx concentrations in mucinous, serous cystadenomas and follicular cysts was small.

Immunohistochemical study of iNOS expression showed its small level in follicular cysts and benign cystadenomas, but high level in cystadenocarcinomas.

Thus, NO and iNOS effect of on hyperproliferation processes in the ovaries is twofold. NO and iNOS reducing expression and their minor activity may impact on the cystic tumor formation and benign tumor formation in the ovaries. NO overexpression and iNOS increased activity associated with the malignancy processes in cystic formations of epithelial origin.

Author Biographies

M. A. Lysenko, Odesa National Medical University; University Hospital ONMedU

Postgraduate student of the Obstetrics and Gynecology Department № 1; Doctor at Surgical Department of minimally invasive methods of diagnosis and treatment

V. G. Dubinina, Odesa National Medical University

MD, professor, head of the Oncology Department with a course of radiation diagnosis, therapy and radiation medicine

О. М. Nosenko, Odesa National Medical University

MD, professor, Obstetrics and Gynecology Department № 1

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Published

2016-04-05

How to Cite

Lysenko, M. A., Dubinina, V. G., & Nosenko О. М. (2016). Nitrosative status in benign epithelial cystic ovarian tumors of nonendometrioid origin. REPRODUCTIVE ENDOCRINOLOGY, (27), 78–82. https://doi.org/10.18370/2309-4117.2016.27.78-82

Issue

No. 27 (2016)

Section

Tumors and pretumoral pathology

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Copyright (c) 2016 M. A. Lysenko, V. G. Dubinina, О. М. Nosenko

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