Antioxidant complex of vitamins and minerals as pregravid preparation of married couple


  • А. О. Исламова SI “Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine“, Ukraine
  • О. А. Ефименко SI “Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine“, Ukraine
  • Т. Ф Татарчук Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine, Ukraine



pregravid preparations, multivitamin preparations, fertilovit


It was found that even a balanced diet is deficient in essential vitamins by 20–30%. There is no doubt that woman should be taken multivitamin preparations during pregnancy. A few months before the planned conception multivitamin preparations should also start taking both spouses.

In recent years for the treatment of infertility in the world are widely used specially developed antioxidants complexes of vitamins and minerals that have proven effective and in the future can be a necessary step for pregravid preparation.

Currently a large number of national and foreign multivitamin supplements designed for women and men, containing a complete set of vitamins necessary for daily consumption quantity. They include multivitamin preparations fertilovit, which have multiple versions.

To study the effectiveness of a multivitamin complex fertilovit in pregravid preparations were examined 60 women planning birth at the age of 24–39 years with minor menstrual irregularities (healthy women). 20 of them for 3 months received fertilovit F (group 1), 20 – fertilovit F 35+ (group 2) and 20 women do not take multivitamin complex as pregravid preparation (control group). Husbands of women, who received fertilovit F or F 35+, also took fertilovit MT over 3 months.

After 3 months of taking a multivitamin complex, and within the next 3 months after pregravid preparation with fertilovit F the following results were observed: 4 pregnancies occurred in a group of 20 women who received fertilovit F, 3 pregnancy occurred in a group of women 35 years after taking fertilovit F 35+; only one pregnancy occurred in the control group.

The study results indicate good efficacy antioxidant complex of vitamins and minerals in combination with other necessary medicines that in each case significantly increases a woman's chances of getting pregnant and thus allows having a healthy baby. The obtained results give grounds to recommend drugs fertilovit for married couple as pregravid preparation.

Author Biographies

А. О. Исламова, SI “Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine“

PhD, researcher of the Endocrine Gynecology Department 

О. А. Ефименко, SI “Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine“

PhD, senior researcher of the Endocrine Gynecology Department

Т. Ф Татарчук, Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine

MD, professor, corresponding member. NAMS of Ukraine, Deputy Director for Research, Head of Endocrine Gynecology


  1. Gorbachev, V.V., Gorbacheva, V.N. Vitamins. Micro and macro elements. Handbook. Minsk. Book House (2002): 544 p.
  2. Strizhakov, A.N., Budanov, P.V. “Synergistic vitamin therapy is a base for optimization of pregravid preparation and pregnancy management.” Questions of gynecology, obstetrics and perinatology (2006).
  3. Shikh, E.V. Vitamin status and its restoration with the help of pharmacological correction by vitamin products. Thesis abstract on the degree of MD. Moscow (2002): 47 p.
  4. Shikh, E.V. “The effectiveness of vitamin and mineral complexes in terms of micronutrients interaction.” Pharmaceutical Bulletin 37.358 (2004).
  5. Wirleitner, B., Zech, N.H., Vanderzwalmen, P., Stecher, A. “Oxidative stress in primary infertility of women.” Global Journal of Medical Research (H): Orthopedic and musculoskeletal system 2.13 (2013).
  6. Berkane, N., Uzan, S. “The use of supplements in pregnancy.” J Gynecol Obstet Biol Reprod 33 (2004): 33–36.
  7. Grischke, E.M. “Nutrition during pregnancy – current aspects.” MMW Fortschr Med 146 (2004): 29–30.
  8. Goh, Y.I., Bollano, E., Einarson, T.R., Koren, G. “Prenatal multivitamin supplementation and rates of congenital anomalies: a meta–analysis.” J Obstet Gynaecol Can 28 (2006): 680–689.
  9. Daly, S., Cotter, A., Molloy, A.E., Scott, J. “Homocysteine and folic acid: implications for pregnancy.” Semin Vasc Med 5 (2005): 190–200.
  10. Maneesh, M., Jayalekshmi, H. “Role of reactive oxygen species and antioxidants on pathophysiology of male reproduction.” Indian Journal of Clinical Biochemistry 21.2 (2006): 80–89.
  11. Ajayi, R., Okhowat, J., Spitzer, D., Schechinger, B., Zech, N.H. “Effect of multivitamin antioxidant complex Fertilovit sperm quality, according to the criteria of the morphological analysis of motile sperm organelle (MSOME).” JBRA Assisted Reproduction 17.1 (2013): 27–31.



How to Cite

Исламова, А. О., Ефименко, О. А., & Татарчук, Т. Ф. (2016). Antioxidant complex of vitamins and minerals as pregravid preparation of married couple. REPRODUCTIVE ENDOCRINOLOGY, (27), 62–66.