The state of sympathoadrenal and vagoinsular systems, hormonal status in men with chronic allergic dermatoses
Keywords:chronic allergic dermatoses, hormonal status, sympathoadrenal system, vagoinsular system
The incidence of somatic pathology increased with age, and in particular increased incidence of allergic dermatoses. Today poorly understood of changes in the sympathoadrenal and vagoinsular systems, changes of sexual gormones and levels of gonadotropins, which occur in patients with chronic allergic dermatoses and impact their course, that justifies the need for research in this direction.
Study objective was to study the changes of the sympathoadrenal and vagoinsular systems state, levels of sexual and gonadotropin-releasing hormone in men with allergic dermatoses depending on age.
There were examined 148 men: 17 healthy individuals aged 25–44 years and 131 at the age of 45–64 years, including 33 healthy men and 98 patients with chronic allergic dermatoses.
We studied the excretion of adrenaline, noradrenaline, dihydroxyphenylalanine, dopamine; the concentration of testosterone, follicle-stimulating hormone and luteinizing hormone, testosterone blinding globulin, prolactin, insulin, and cortisol in the blood by ELISA.
Results of the study showed that in 45–64 years old patients with chronic allergic dermatoses there is a decrease of activity, and reserve capacity of the sympathoadrenal system during acceleration biosynthesis of catecholamines at the stages of dihydroxyphenylalanine transformation to dopamine and dopamine to norepinephrine that is indicates a decrease of catecholamines reserves in tissue. In 45–64 years old men with chronic allergic dermatoses observed severely impaired autonomic homeostasis, manifested in inhibition activity of the sympathetic nervous system, increased tone and reactivity of the parasympathetic system; decreased activity of compensatory reactions. In the presence of chronic allergic in 45–64 years old men are set significantly lower testosterone levels and significantly higher levels of follicle-stimulating and luteinizing hormones, prolactin, testosterone blinding globulin compared with a
group of healthy men of similar age.
Results of the study dictate the need to find ways to correct the identified changes in the sympathoadrenal and vagoinsular systems, hormonal status in men 45-64 years with chronic allergic dermatoses.
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