Treatment of genital warts: focus on vaginal dysbiosis
Keywords:human papillomavirus infection, genital warts, vaginal dysbiosis, tamistol
Bacterial vaginosis is a common companion of human papillomavirus infection. It can also be combined with vaginal candidiasis and tends to recur. Recurrences are due to the presence of commensal vaginal Atopobium vaginae. Bacterial vaginosis is pathogenically associated with the blockade of the inflammatory reaction at the vaginal mucosa level. Therefore it is necessary to use drugs for sanitation with the active ingredient that effects anaerobes, Gardnerella vaginalis, Atopobium vaginae, yeasts, has immunomodulatory properties, does not inhibit the lactobacillus growth and has no cross-resistance with other antibacterial drugs. Myramistin are satisfied all these requirements.
The study of the efficiency of vaginal suppositories with myramistin (drug tamistol) in treatment of patients with genital warts was performed. There were examined 142 women. Group I included 30 healthy women; group II included 55 patients with genital warts (28 participants in IIA subgroup with bacterial vaginosis, 27 patients in IIB subgroup with bacterial vaginosis and chronic recurrent vaginal candidiasis). Group III was included 57 women with genital warts (29 patients with bacterial vaginosis in IIIA subgroup and 28 women with bacterial vaginosis and chronic recurrent vaginal candidiasis in the IIIB subgroup).
Group II patients was performed the chemical destruction of genital warts after rectal use recombinant interferon suppositories for 10 days. Group III patients additionally prescribe a course of the vaginal suppositories tamistol within 10 days.
The results of the study suggest that the use of tamistol suppositories in complex treatment of patients with genital warts increases the effectiveness of remedial measures. Restoration of the vaginal microbial landscape with tamistol reduced the need for chemical destruction sessions of warts and the number of recurrences. The results suggest theoretically justified the use of immunomodulators and sanitation of the vagina in a complex treatment of human papillomavirus infection.
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