Polymorphic variants progesterone receptor gene: case-control study among women with first trimester miscarriage

Authors

DOI:

https://doi.org/10.18370/2309-4117.2015.26.66-70

Keywords:

progesterone, miscarriage, luteal phase deficiency, progesterone receptor, early reproductive losses, missed abortion

Abstract

Low levels of progesterone and, accordingly, the associated luteal phase deficiency of the menstrual cycle, is traditionally considered the most common cause of such reproductive disorders as infertility and miscarriage. It is believed that insufficient levels of progesterone can result in the above-mentioned pathological conditions of the reproductive function of women. However, the prescribing physician therapy to restore the progesterone level is not always effective.

The search for the causes of the ineffectiveness of standard therapy led to the conclusion that the most common cause of luteal phase deficiency is the lack of effect of progesterone on the endometrium.

This article is provides an overview of published data on the role of progesterone receptor system and its genesis in the early reproductive losses. It has also conducted its own study to determine SNPs 1031G/C, 1978G/T, 2310C/Tgene PGR as one of the factors in the development of miscarriage I trimester. The study group consisted of 52 women with miscarriage (control group consisted 41 healthy women previously had labor, unencumbered reproductive history and asked for a medical abortion).

Analysis of the survey results showed that heterozygous carriers of mutations G1031C, C2310T, G1978T PGR gene is not an independent risk factor for miscarriage (mutant alleles were found in 40.4% of the women in the study group and 37.8% of women in the control group); genotype homozygous for the mutations G1031C, C2310T, G1978T PGR gene were found just only in the study group – 2.1, 2.14 and 5.2% of cases respectively, which probably can be attributed to factors propensity to miscarriages. The duration of the menstrual cycle in women who have PR gene mutations carriers was significantly higher for 2–3 days compared to women who are not carriers of mutations.

It is expedient to conduct such studies in the group of women with confirmed luteal phase deficiency on the basis of reliable criteria (histological studies, etc.) and large volume sample.

Author Biographies

М. П. Веропотвелян, Interregional Center of Medical Genetics and Prenatal Diagnostics, Kryvyi Rih

MD, chief physician

Ю. С. Погуляй, Interregional Center of Medical Genetics and Prenatal Diagnostics, Kryvyi Rih

Biologist at the laboratory 

М. М. Свиридов, First City Hospital, Kryvyi Rih

Obstetrician-gynecologist at the Gynecological Department

П. С. Горук, Interregional Center of Medical Genetics and Prenatal Diagnostics, Kryvyi Rih

Head of the Inpatient Unit

References

  1. Kutteh, W.H. “Current state of habitual miscarriage problems.” Curr Opin Obstet Gynecol, 11(5) (1999): 435–439.
  2. Clinical practice guidelines. Obstetrics and gynecology. Issue 2 / Ed. by V.I. Kulakov. Moscow. GEOTAR-Media (2006): 560 p.
  3. Obstetrics: national guidelines // Ed. by E.K. Aylamazyan, V.I. Kulakov, V.E. Radzinskiy, G.M. Savelyeva. Moscow. GEOTAR-Media (2007): 1200 p.
  4. The genetic passport as a the basis of individual and predictive medicine // Ed. by V.S. Baranov. St. Petersburg (2009).
  5. Kurz, C., et al. “The PROGINS progesterone receptor gene polymorphism and idiopathic recurrent miscarriage.” Soc Gynecol Investig, 8(2001): 295–298.
  6. Pakharenko, L.V. “Progesterone receptor gene polymorphisms in the development of premenstrual syndrome.” Women's Health, 9(95) (2014): 154–157.
  7. Dovzhykova, I.V. “The synthesis of sex steroid hormones in the placenta (review).” Bulletin of the Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS, 41(2011): 85–88.
  8. Peng, L., Huang. Y., Jin. F., Jiang. S.W., Payne, A.H. “Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1.” Mol Endocrinol, 18(8) (2004): 2049–2060.
  9. Borrell, A., Stergiotou, I. “Мiscarriage in contemporary maternal – fetal medicine: targeting clinical dilemmas.” Ultrasound in Obstetrics & Gynecology, 5(2013): 491–497.

Published

2015-12-28

How to Cite

Веропотвелян, М. П., Погуляй, Ю. С., Свиридов, М. М., & Горук, П. С. (2015). Polymorphic variants progesterone receptor gene: case-control study among women with first trimester miscarriage. REPRODUCTIVE ENDOCRINOLOGY, (26), 66–70. https://doi.org/10.18370/2309-4117.2015.26.66-70

Issue

Section

Scientific Studies

Most read articles by the same author(s)