Possibility of phytotherapy for correction of functional stress-induced menstrual disorders
Keywords:stress-induced menstrual disorders, phytotherapy, Normocycle
About 80% of women of reproductive age are suffer from menstrual disorders, such as dysmenorrhea, intermenstrual bleeding, irregular menstruation.
The main causes of dysregulation of the reproductive system are: significant change in body weight, increased physical activity, nervous and mental strain, smoking, taking medications that affect neurotransmitters and neuromodulators, various endocrinopathies, inflammatory diseases of the sexual sphere, surgery on the ovaries.
It was found that menstrual irregularities can be as markers desadaptation on the background of increased psycho-emotional stress.
Menstrual disorders require long-term treatment, so it is important to choose not only effective, but also safe, well-tolerated drugs with minimal side effects. To date, these properties have herbal medicines, which greatly expand the treatment of menstrual disorders.
The study to examine the effectiveness of the phytodrug normocycle in patients with stress-induced menstrual disorders was performed.
The study includes 78 patients aged 17–25 years with functional disorders of the menstrual cycle such as opsomenorrhea (main group). Patients of the main group received the drug normocycle for 3 months. The control group consisted of 40 healthy women of the same age.
The effectiveness of the prescribed treatment was studied on the level of mental stress, dynamics of hormonal profile indicators, dynamics of the menstrual cycle parameters, ultrasound picture dynamic.
Menstrual cycle returned to normal in more than 70% of women after completion of normocycle therapy. At the same time the drug was well tolerated and there were no side effects of the drug.
The study results showed that use of the drug normocycle in women with stress-induced disorders of the menstrual cycle helps to reduce mental stress, stabilize the status of the nervous system that leads to the normalization of hormonal balance and restore the menstruation rhythm. Extending therapy up to 6 months increases the effectiveness of treatment, leads to the restoration of full luteal phase of the menstrual cycle.
- Moskaleva, A.Y., Kirgizova, O.Y. “Treatment optimization of retention formations of ovaries in women with ovarian dysfunction of central origin.” Bulletin of ESSC SB RAMS, 1(77) (2011): 98–99.
- Razumeyko, D.P., Markush, I.M. “Treatment optimization for patients with salpingo-oophoritis and menstrual dysfunction in women of reproductive age.” Actual Questions of Pediatrics, Obstetrics and Gynecology, 2(2012): 184–187.
- Tatarchuk, T.F., Kalugina, L.V. “New trends in the treatment of premenstrual tension syndrome.” Women's Health, 3(39) (2009): 47–49.
- Tatarchuk, T.F. “The effectiveness of drugs with dopaminergic action in the treatment of dyshormonal stress-induced pathology.” Reproductive Endocrinology, 3(11) (2013): 90–94.
- Bhatnagar, M., Sisodia, S. S., Bhatnagar, R. “Antiulcer and antioxidant activiti of Asparagus racemosus willd and Withaniasomnifera dunal in rats.” Ann New York Acid Sci, 1056(2005): 261–278.
- Bhutani, K. K., Jadhav, A.N., Kalia, V.J. “Effect of Symplocos racemosa Roxb. on gonadotropin release in immature female rats and ovarian histology.” Ethnopharmacol, 94(1) (2004): 197–200.
- De Silva, L. B., Mahendran, M. “The chemical contituens of Symplocos racemosa.” J Natl Sci Council Sri Lanka, 7(1979): 1–3.
- Devmurari, V. P. “Antibacterial evaluation and phytochemical screening of Symplocos racemosa.” Int J PharmTech Res, 2(2010): 1359–1363.
- Devmurari, V. “Phytochemical screening and evaluation of antioxidant activity of Symplocos racemosa.” Roxb J Adv Sci Res, 1(2010a): 28–34.
- Devmurari, V. “Phytochemical screening and evaluation and phytochemical screening of Symplocos racemosa.” Roxb Int J Pharm Tech Res, 2(2010a): 1359–1363.
- Dhananjay Wakchaure, Dilpesh Jain, Abhay Kumar Singhai, et al. “Hepatoprotective activity of Symplocos racemosa bark on carbon tetrachloride-induced hepatic damage in rats.” J Ayurveda Integr Med, 2(3) (2011): 137–143.
- Diwanay, S., Chitre, D., Patwardhan, B. “Immunoprotection by botanical drugs in cancer chemotherapy.” J Ethnopharmacol, 90(2004): 49–55.
- Gulfam Nasar, Irum Saba. “Antibacterial activity of chemical constituents isolated from Asparagus racemosus.” Bangladesh J Pharmacol, 9(2014): 1–3.
- Hanumant U. Bhusnar, Dheeraj H. Nagore, Sanjay U. Napanikar. “Profile of Symplocos racemosa.” Pharmacologia, 5(2014): 76–83.
- Hussain, S., Gaffney, J., Ahmed, N., Slevin, M., Choudhary, M.I., et al. “An investigation of the kinetic and anti-angiogenic properties of plant glycoside inhibitors of thimidine phosphorylase.” J Asian Nat Prod Res, 11(2009): 159–167.
- Laddawan Lalert, Hathairat Kruevaisayawan, Patcharada Amatyakul, et al. “Neuroprotective Effects of the Asparagus racemosus Root Extract on Ovariectomized Rats.” J Physiol Biomed Sci, 26(1) (2013): 18–22.
- Kanwar, A.S., Bhutani, K.K. “Effect of Clorophytum arundinaceum, Asparagus adscendens and Asparagus racemosus on proinflammatory cytocine and corticosterone levels produced by stress.” Phytother Res, 24(2010): 162–166.
- Kumar, G.S., Jayaveera, K.N., Kumar, С.K.A., Sanjay, U.P., Swamy, B.M.V., et al. “Antimicrobial effects of Indian medicinal plants against acneinducing bacteria.” Trop J Pharm Res, 6(2007): 717–723.
- Mamata Jadhav, Sasikumar Menon, Sunita Shailajan. “Anti-androgenic effect of Symplocos racemosa Roxb. against letrozole induced polycystic ovary using rat model.” Journal of Coastal Life Medicine, 1(4) (2013): 309–314.
- Mandal, S.C., Nandy, A., Pal, M., Saha, B.P. “Evaluation of antibacterial activity of Asparagus racemosus Wild root.” Phytother Res, 14(2000): 118–119.
- Muhammad Abdullah Shah, Syed Muhammad Abdullah, Muhammad Azim Khan, et al. “Ethnopharmacological of curcuma longa: a review.” IJPSR, 4(1) (2013): 103–112.
- Ojha, R., Sahu, A.N., Muruganandam, A.V., Singh, G.K., Krishnamurthy, S. “Asparagus recemosus enhances memory and protects against amnesia in rodent models.” Brain Cogn, 74(2010): 1–9.
- Patel, L.S., Patel, R.S. “Antimicrobial Activity of Asparagus racemesus Wild From Leaf Extracts.” Int J Sci Res Pub, 3(2013): 1–3.
- Ramachandran Vadivelan, Mandal Dipanjan, Payyavala Umasankar, et al. “Hypoglycemic, antioxidant and hypolipidemic activity of Asparagus racemosuson streptozotocin-induced diabetic in rats.” Adv Appl Sci Res, 2(3) (2011): 179–185.
- Rajandeep Kaur, Harpreet Kaur, Ajaib Singh Dhindsa. “Glycyrrhiza glabra: a phytopharmacological review.” IJPSR, 4(7) (2013): 2470–2477.
- Raval, B.P., Patel, J.D., Patel, B.A., Ganure, A.L. “Potent in vitro anticancer activity of Symplocos racemosa bark.” Rom J Biol Plant Biol, 54(2009): 135–140.
- Rege, N.N., Thatte, U.M., Dahanukar, S.A. “Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine.” Phytother Res, 13(1999): 275–291.
- Saraswathi, C.D., Gupta, S.K., Sreemantula, S. "Protective effect of Symplocos racemosa bark on cold restraint stress induced reproductive changes in female rats.” J Nat Prod, 5(2012): 251–258.
- Shadia, A.T. “Yassin Herbal Remedy used by Rural Adolescent girls with Menstrual Disorders.” Journal of American Science, 8(1) (2012).
- Sharma, S.K., Sharma, S.M., Saini, V., Mohapatra, S. “Evaluation of analgesic and anti-inflammatory activiti of Symplocos racemosa.” Int Res J Pharm, 4(2013): 136–139.
- Sing, G.K., Garabadu, D., Muruganandam, A.V. “Antidepresssant activity of Asparagus racemosus in rodent models.” Pharmacol Biochem Behav, 91(2009): 283–290.
- Tanuj Joshi, Sangeeta P. Sach, Anita Singh. “Antistress activity of Asparagus racemosus.” Indian Journal of Experimental Biology, 50(2012): 419–424.
- Vijayabaskaran, M., Amol K. Badkhal, Babu, G., et al. “Antitumor Activity and Antioxidant Status of Symplocos racemosa Roxb Against Ehrlich Ascites Carcinoma in Swiss Albino Mice.” RJPBCS, 3(2010): 306–314.
- Vijayabaskaran, M., Yuvaraja, K.R., Babu, G., Perumal, P., Jayakar, B. “Isolation and characterization of phenolic glycoside from the barc of Symplocos racemosa Roxb.” E-J Chem, 7(2010): 255–260.
- Vidyasagar, G.M., Murthy, S.M. “Siddalinga Ethnomedicinal plants used to treat menstrual disorders by tribal people in Bellary district of Karnataka.” India IJPLS, 3(2012): 1871–1876.
- Visavadiya, N.P., Narasimhacharya, R.L. “Hypolipidemic and antioxidant activities in Asparagus racemosus in hypercholesteremic rats.” Indian J Pharmacol, 37(2005): 376–380.
- Wakchaure, D., Jain, D., Singhai, A.K., Somani, R. “Hepatoprotective activity of Symlocos racemosa barc on carbon tetrachloride-induced of Symplocos racemosa bark on carbon tetrachloride-induced hepatic damage in rats.” J Ayurveda Integrative Med, 2(2010): 137–143.
- Tolstikov, G.A., Baltina, L.A., Grankina, V.P. Licorice: biodiversity, chemistry and application in medicine. Novosibirsk. Academic publishing house “Geo” (2007): 311 p.
How to Cite
Copyright (c) 2015 Н. В. Косей, Т. Ф. Татарчук, Н. А. Редько, Н. В. Яроцкая
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.