Risk of cardiovascular diseases in reproductive aging of women
Keywords:reproductive aging, aging theory, risk of cardiovascular diseases, menopausal hormone therapy
Characteristics of reproductive age and association of clinical and endocrine changes in women of reproductive age from late to early menopause are presents in this article.
We consider the theory of aging: the theory of evolution on genetically programmed aging, free-radical, mitochondrial, elevating, immunological theory, the hypothesis of the existence of the genetic program of self-destruction.
The article focuses on the rigidity of the arterial wall that is directly related to the speed of the pulse wave, the definition of which is the standard measure of rigidity and can be used as a prognostic factor of death from cardiovascular diseases.
Modern researchers consider the biomechanical properties of the vessels (the rate of viscoelastic state artery, pulse wave velocity) as one of the criteria of biological age, because, illustrating the close relationship with chronological age in conjunction with other criteria, they characterize a slow or rapid type of aging women.
Menopause is accompanied by atherogenic changes in the lipid composition of the blood, namely, increased levels of LDL cholesterol and decreased levels of HDL cholesterol, and also an increase in the obesity prevalence, insulin resistance and diabetes, mostly type-2. Therefore, patients with hypertension in postmenopausal period often have a variety of the metabolic disorders that along with the increase in blood pressure potentially increases the risk of cardiovascular complications. Manifestation of the pre-climacteric syndrome, the duration of which in 35% of women more than 5 years, is worsens hypertension, and in patients with hypertension is more common it pathological course.
Hot flushes development correlated with subclinical symptoms of cardiovascular diseases, which manifests endothelial dysfunction, calcification of the aorta, the increase in intima-media thickness of the carotid artery, increased levels of procoagulant factors dislipoproteinemia development.
Numerous publications have a lot of results on the potential use of hormonal drugs for the prevention of aging processes in the vessel wall in order to maintain the normal state of the cardiovascular system of women.
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Copyright (c) 2015 П. Н. Веропотвелян, И. С. Цехмистренко, Н. П. Веропотвелян, Н. Ю. Троян
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