To the question of complex treatment of endometriosis

Н. Ф. Захаренко, Н. В. Коваленко, І. П. Маноляк

Abstract


Work on improving the quality of antiproliferative treatment of endometriosis with regard morphological and immunohistochemical data was performed.

At the first phase of the study the activity of proliferation markers and apoptosis markers in patients with various forms of endometriosis were studies: in 35 patients with internal endometriosis (adenomyosis), 52 patients with external genital endometriosis and 19 patients with extragenital endometriosis. As a result, it was found that in the lesions of endometriosis there are low apoptosis, high cell proliferative activity and proliferative endometrium type is prevalent (endometrial hyperplasia).

At the second phase of the study antiproliferative properties of drug Epigalin in the treatment of endometriosis were assessment. 38 patients with adenomyosis and marked pain syndrome participated in a study: 18 patients received dienogest and 20 patients received dienogest and administered Epigalin. The result revealed that Epigalin use in the treatment of endometriosis allows controlling proliferative potential of the endometrium cells.


Keywords


endometriosis; antiproliferative treatment; immunohistochemical studies; Epigalin

References


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7. C hatterji, U., Riby, J.E., Taniguchi, Т., Bjeldanes, E.X., et al. “Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells.” Carcinogeneses, 1 (Vol. 1) (2004): 119–1128.

8. Darai, E., Detchev, R., Hugol, D., Quang, N. T. “Serum and cyst fluid levels of interleukin (IL) -6, IL-8 and tumour necrosis factor-alpha in women with endometriomas and benign and malignant cystic ovarian tumours.” Hum Reprod, 18(2003): 1681–1685.

9. Dmowski, W.P., Ding, J., Shen, J., Rana, N., Fernandez, B.B., Braun D.P. “Apoptosis in endometrial glandular and stromal cells in women with and without endometriosis.” Hum Reprod, 16(2001): 1802–1808.

10. Firestone, G.L., Bjeldanes, L.F. “Indole-3-carbinol and З-З-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp 1 transcription factor interactions.” J Nutr, 133(2003): 2448–2455.

11. M asuda, M., Suzuki, M., Lim, J.T.E., Weinstein, I.E. “Epigallocatechin-3-gallate inhibits activation of HER -2/neu and downstream signaling pathways in human heat and neck and breast carcinoma cells.” Clin Cancer Res, 9(2003): 3486–3491.

12. R ahman, K.M., Aranha, O., Sarkar, F.H. “Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epitelial cells.” Nutr Cancer, 45(2003): 101–112.

13. R eed, G.A., Peterson, K.S., Smith, H.J., Gray, J.C., Sullivan, D.K., et al. “A phase I study of indole-3-carbinol in women: tolerability and effects.” Cancer Epidemiol Biomarkers Prev, 8(2005).

14. Scholzen, Т., Gerdes, J. “The Ki-67 protein: from the know and the unknown.” J Cell Physiol, 3(2000): 311–312.

15. Thangapazham, R.L., Singh, A.K., Sharma, A., et.al. “Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo.” Cancer Lett, 8(2007): 832–841.





DOI: http://dx.doi.org/10.18370/2309-4117.2015.23.28-33

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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)