To the question of complex treatment of endometriosis


  • Н. Ф. Захаренко Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine, Ukraine
  • Н. В. Коваленко Kyiv City Hospital number 9, Ukraine
  • І. П. Маноляк Institute of Pediatrics, Obstetrics and Gynecology of the NAM S of Ukraine, Ukraine



endometriosis, antiproliferative treatment, immunohistochemical studies, Epigalin


Work on improving the quality of antiproliferative treatment of endometriosis with regard morphological and immunohistochemical data was performed.

At the first phase of the study the activity of proliferation markers and apoptosis markers in patients with various forms of endometriosis were studies: in 35 patients with internal endometriosis (adenomyosis), 52 patients with external genital endometriosis and 19 patients with extragenital endometriosis. As a result, it was found that in the lesions of endometriosis there are low apoptosis, high cell proliferative activity and proliferative endometrium type is prevalent (endometrial hyperplasia).

At the second phase of the study antiproliferative properties of drug Epigalin in the treatment of endometriosis were assessment. 38 patients with adenomyosis and marked pain syndrome participated in a study: 18 patients received dienogest and 20 patients received dienogest and administered Epigalin. The result revealed that Epigalin use in the treatment of endometriosis allows controlling proliferative potential of the endometrium cells.

Author Biographies

Н. Ф. Захаренко, Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine

MD, chief researcher at the Endocrine Gynecology Department

Н. В. Коваленко, Kyiv City Hospital number 9

Doctor of the Gynecological Department

І. П. Маноляк, Institute of Pediatrics, Obstetrics and Gynecology of the NAM S of Ukraine

Junior researcher at the Endocrine Gynecology Department


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How to Cite

Захаренко, Н. Ф., Коваленко, Н. В., & Маноляк, І. П. (2015). To the question of complex treatment of endometriosis. REPRODUCTIVE ENDOCRINOLOGY, (23), 28–33.