Role of calcium and vitamin d in prevention of postmenopausal osteoporosis in patients with endometriosis

Н. Ф. Захаренко, Н. В. Коваленко, В. П. Ковбасий

Abstract


The study to assess the effectiveness of the use of the drug Calcium-D3 Nycomed for the prevention and correction of disorders of calcium-phosphorus metabolism, bone metabolism in 67 patients with endometriosis on the background of climacteric syndrome and calcium deficiency was performed. 35 patients (main group) against the symptomatic treatment of climacteric syndrome were prescribed Calcium-D3 Nycomed. 32 patients, who did not receive calcium supplements, entered the control group. The period of observation in the course of treatment was 3 months.

The most important result of the treatment was slowing or stopping bone loss resulting from the use of Calcium-Dз Nycomed. It is possible to recommend the use of this drug in patients with endometriosis and symptoms of hypocalcemia on the background of climacteric syndrome for the prevention and treatment of osteopenic syndrome


Keywords


endometriosis; menopause; osteoporosis; vitamin D; Calcium-D3 Nycomed

References


Adamyan, L.V. Genetic aspects of gynecological diseases. Moscow. GEOTAR -Media (2008): 164–168.

Baran, D.T., Faulkner, K.G., Genant, H.K., Miller, P.D. “Diagnostics and treatment of osteoporosis: the principles of the bone densitometry use.” Osteoporosis and osteopathy, 3(1998): 10–15.

Zakharenko, N.F., Tatarchuk, T.F., Kovalenko, N.V. “The role of oxidative stress in the genesis of endometriosis.” Reproductive Endocrinology, 4(18) (2014): 13–16.

Medical and demographic atlas of Ukraine. Ukraine in the European context, the main causes of mortality. Issue 14 / V.P. Voitenko, A.V. Pisaruk, N.M. Koshel, M.G. Akhaladze. Kyiv. Fenix (2012): 62 p.

Smetnik, V.P., Yureneva, S.V. “Postmenopausal osteoporosis.” Difficult Patient, 6 (Vol. 2) (2004): 27–33.

Toroptseva, N.V. “Prevention of postmenopausal osteoporosis: the role of calcium and vitamin D.” Gynecology, 5–6 (Vol. 7) (2006): 52–55.

Body, J.J., et al. “Vitamin D with calcium reduces mortality: patient level pooled analysis of 70.528 patient fromeight major vitamin D trials.” Osteoporos Int, 23(Suppl. 1) (2012): 1–23.

R ejnmark, L., Aveneil, A., Masud, T., et al. “Vitamin D with Calcium Reduces Mortality: Patient Level Pooled Analysis of 70,528 Patients from Eight Major Vitamin D Trials.” J Clin Endocrin Metab, (2012): 1–12.

Buyalos, R.P., et al. “Endometriosis-associated infertility.” Curr Opin Obstet Gynecol, 12(2000): 377–381.

C urhan, G.C., Willett, W.C., et al. “Dietary factors and the risk of incident kidney stones in younger women: Nurses’ Health Study ІІ.” Arch Intern Med, 164(8) (2004): 885–891.

Hummelshoj, L. “Medical needs in endometriosis.” Gynaecology Forum, 15(2) (2010): 5–7.

N eukomm, C., et al. “Die Endometriose – eine wenig bekannte, oft unerkannte Frauenkrankheit.” Schweiz Med Forum, 8(30–31) (2008): 539–543.

C occia, M.E., et al. Hum Reprod, 11(2011): 3000–3007.


GOST Style Citations


1. Адамян, Л.В. Генетические аспекты гинекологических заболеваний. — М.: ГЭОТАР-Медиа. — 2008. — С. 164–168.

2. Баран, Д.Т. Диагностика и лечение остеопороза: принципы использования костной денситометрии / Д.Т. Баран, К.Г. Фолкнер, Х.К. Генант, П.Д. Миллер // Остеопороз и остеопатии. — 1998. — № 3. — С. 10–15.

3. Захаренко, Н.Ф. Роль оксидативного стресу в ґенезі ендометріозу / Н.Ф. Захаренко, Т.Ф. Татарчук, Н.В. Коваленко // Репродуктивная эндокринология. — 2014. — №4 (18). — С. 13–16.

4. Медико-демографічний атлас України. Україна в європейському контексті: смертність від головних причин. Вип. 14 / В.П. Войтенко, А.В. Писарук, Н.М. Кошель, М.Г. Ахаладзе. — К.: Фенікс. — 2012. — 62 с.

5. Сметник, В.П. Постменопаузальный остеопороз / В.П. Сметник, С.В. Юренева // Трудный пациент. — 2004. — № 6, Т. 2. — С. 27–33.

6. Торопцева, Н.В. Профилактика постменопаузального остеопороза: роль препаратов кальция и витамина D / Н.В. Торопцева // Гинекология. — 2006. — № 5–6, Т. 7. — С. 52–55.

7. Body, J.J., et al. “Vitamin D with calcium reduces mortality: patient level pooled analysis of 70.528 patient fromeight major vitamin D trials.” Osteoporos Int, 23(Suppl. 1) (2012): 1–23.

8. R ejnmark, L., Aveneil, A., Masud, T., et al. “Vitamin D with Calcium Reduces Mortality: Patient Level Pooled Analysis of 70,528 Patients from Eight Major Vitamin D Trials.” J Clin Endocrin Metab, (2012): 1–12.

9. Buyalos, R.P., et al. “Endometriosis-associated infertility.” Curr Opin Obstet Gynecol, 12(2000): 377–381.

10. C urhan, G.C., Willett, W.C., et al. “Dietary factors and the risk of incident kidney stones in younger women: Nurses’ Health Study ІІ.” Arch Intern Med, 164(8) (2004): 885–891.

11. Hummelshoj, L. “Medical needs in endometriosis.” Gynaecology Forum, 15(2) (2010): 5–7.

12. N eukomm, C., et al. “Die Endometriose – eine wenig bekannte, oft unerkannte Frauenkrankheit.” Schweiz Med Forum, 8(30–31) (2008): 539–543.

13. C occia, M.E., et al. Hum Reprod, 11(2011): 3000–3007.





DOI: http://dx.doi.org/10.18370/2309-4117.2015.22.70-75

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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)