Menarche, puberty and vitamin D


  • Elina Chaykivska Lviv National Medical University, Lviv, Ukraine,



menarche, vitamin D3, puberty, precocious puberty


Puberty is the development process - result of a complex series of molecular and physiological events, culminating in reproductive capability. Gonadotropin-releasing hormone actively released from specialized neurons of the hypothalamus stimulates gonadal activation and triggers physical changes of puberty through initiation of the hormonal cascade. Epidemiologic studies and numerous clinical trials claim that sufficient levels of vitamin D3 are essential for normal physiological growth, development and puberty, by activation of the neurohormonal multisystem in the hypothalamus-pituitary-gonadal axis. Various scientific studies investigate the role of vitamin D3 and its metabolites in specific reproductive disorders of women and men. All these data contribute to intensive research on vitamin D3 and its receptor as a potential factor, affecting the pathogenesis of a numerous diseases, connected with its non-classical function, such as diabetes, obesity, cancer, puberty disorders and infertility. In the last decade, the prevalence of vitamin D3 deficiency has been increasing in many parts of the world, that has caused an increasing number of medical research on the subject. Nevertheless, data on the vitamin D status and its association with puberty in girls are constrained. This paper was written to present different studies on vitamin D3 and its influence on puberty through the regulation of the neurohormonal system during sexual maturity

Author Biography

Elina Chaykivska, Lviv National Medical University, Lviv, Ukraine

Assistant professor of the Obstetrics, Gynecology and Perinatology Departmen


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How to Cite

Chaykivska, E. (2015). Menarche, puberty and vitamin D. REPRODUCTIVE ENDOCRINOLOGY, (22), 47–49.



Children gynecology