Menarche, puberty and vitamin D

Elina Chaykivska

Abstract


Puberty is the development process - result of a complex series of molecular and physiological events, culminating in reproductive capability. Gonadotropin-releasing hormone actively released from specialized neurons of the hypothalamus stimulates gonadal activation and triggers physical changes of puberty through initiation of the hormonal cascade. Epidemiologic studies and numerous clinical trials claim that sufficient levels of vitamin D3 are essential for normal physiological growth, development and puberty, by activation of the neurohormonal multisystem in the hypothalamus-pituitary-gonadal axis. Various scientific studies investigate the role of vitamin D3 and its metabolites in specific reproductive disorders of women and men. All these data contribute to intensive research on vitamin D3 and its receptor as a potential factor, affecting the pathogenesis of a numerous diseases, connected with its non-classical function, such as diabetes, obesity, cancer, puberty disorders and infertility. In the last decade, the prevalence of vitamin D3 deficiency has been increasing in many parts of the world, that has caused an increasing number of medical research on the subject. Nevertheless, data on the vitamin D status and its association with puberty in girls are constrained. This paper was written to present different studies on vitamin D3 and its influence on puberty through the regulation of the neurohormonal system during sexual maturity


Keywords


menarche; vitamin D3; puberty; precocious puberty

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References


Lee, H.S., Kim, Y.J., Shim, Y.S., Jeong, H.R., Kwon, E., Hwang, J.S. “Associations between serum vitamin D levels and precocious puberty in girls.” Ann Pediatr Endocrinol Metab, 19(2) (2014): 91–95.

D iVall, S.A., Radovick, S. “Pubertal development and menarche.” Ann NY Acad Sci, 1135(2008): 19–28.

Herbison, A.E., Moenter, S.M. “Depolarising and hyperpolarising actions of GABA(A) receptor activation on gonadotropinreleasing hormone neuron requirements for puberty, ovulation, and fertility.” Endocrinology, 149(2) (2008): 597–604.

D icken, C.L., Israel, D.D., Davis, J.B., Sun, Y., Shu, J., Hardin, J., Neal-Perry, G. “ Peripubertal vitamin D3 deficiency delays puberty and disrupts the estrous cycle in adult female mice.” Biol of Reprod, 87(2) (2012): 51.

E yles, D.W., Smith, S., Kinobe, R., Hewison, M., McGrath, J.J. “Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain.” J Chem Neuroanat, 29(1) (2005): 21–30.

W alker, D.M., Juenger, T.E., Gore, A.C. “Developmental profiles of neuroendocrine gene expression in the preoptic area of male rats.” Endocrinology, 150(5) (2009): 2308–2316.

Gezen-Ak, D., Dursun, E., Yilmazer, S. “The effects of vitamin D receptor silecing on the expression of LVSCC -A1C and the release of NGF in cortical neurons.” PLoS One, 6(3) (2011): e17553.

M alinina, E., Druzin, M., Johansson, S. “Differential control of spontaneous and evoked GABA release by presynaptic L-type Ca2+ channel in the rat medial preoptic nucleus.” J Neurophysiol, 104(1) (2010): 200–209.

Kinuta, K., Tanaka, H., Moriwake, T., Aya, K., Kato, S., Seino, Y. “Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads.” Endocrinology, 141(4) (2000): 1317–1324.

Long, J.-R., Xu, H., Zhao, L.-J., Liu, P.-Y., Shen, H., Liu, Y.-J., Xiong, D.-H., Xiao, P., Liu, Y.-Z., Dvornyk, V., Li, J.-L., Recker, R. R., Deng, H.-W. “The oestrogen receptor a gene is linked and/or associated with age of menarche in different ethnic groups.” J Med Genet, 42(2005): 796–800.

Ku, S.Y., Kang, J.W., Kim, H., Kim, Y.D., Jee, B.C., Suh, C.S., Choi, Y.M., Kim, J.G., Moon, S.Y.,

Kim, S.H. “Age at menarche and its influencing factors in North Korean female refugees.” Hum Reprod, 2(3) (2006): 883–886.

E lks, C.E., Perry, J.R., Sulem, P., Chasman, D.I., Franceschini, N., He, C., Lunetta, K.L., Visser, J.A., Byrne, E.M., Cousminer, D.L. “Thirty new loci for age at menarche identified by a meta-analysis of genome-wide associations studies.” Nat Genet, 42(2010): 1077–1085.

He, C., Zhang, C., Hunter, D.J., Hankinson, S.E., Buck-Louis, G.M., Hediger, M.L., Hu, F.B. “Age at menarche and risk of type 2 diabetes: results from 2 large prospective cohort studies.” Am J Epidemiol, 171(2010): 334–344.

D ossus, L., Allen, N., Kaaks, R., Bakken, K., Lund, E., Tjonneland, A., Olsen, A., Overvad, K., Clavel-Chapelon, F., Fournier, A. “Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition.” Int J Cancer, 127(2010): 442–451.

Golub, M.S., Collman, G.W., Foster, P.M., Kimmel, C.A., Rajpert-De Meyts, E., Reiter, E.O., Sharpe, R.M., Skakkebaek, N.E., Toppari, J. “Public health implications of altered puberty timing.” Pediatrics, 121(3) (2008): 218–230.

Villamor, E., Marin, C., Mora-Plazas, M., Baylin, A. “Vitamin D deficiency and age at menarche: a prospective study.” Am J Clin Nutr, 94(2011): 1020–1025.

Grivas, T.B., Vasiliadis, E., Mouzakis, V., Mihas, C., Koufopoulos, G. “Association between adolescent idiopathic scoliosis prevalence and age at menarche in different geographic latitudes.” Scoliosis, 1(2006): 9.

Gilbert-Diamond, D., Baylin, A., Mora-Plazaz, M., Marin, C., Arsenault, J.E., Hughes, M.D., Willett, W.C., Villamor, E. “Vitamin D deficiencyand banthropometric indicators of adiposity in school-age children: a prospective study.” Am J Clin Nutr, 92(2010): 1446–1451.

D avison, K.K., Susman, E.J., Birch, L.L. “Percent Body fat at age 5 predicts earlier pubertal development among girls at age 9.” Pediatrics, 111(2003): 815–821.

Lee, J.M., Appugliese, D., Kacirioti, N., Corwyn, R.F., Bradley, G.H., Lumeng, J.C. “Weight status in young girls and the onset of puberty.” Pediatrics, 119(2007): 624–630.

M artini, L.A., Wood, R.J. “Vitamin D status and the metabolic syndrome.” Nutr Rev, 64(2006): 479–486.

C hew, A., Harris, S.S. “Does vitamin D affect timing of menarche?” Nutr Rev, 71(3) (2013): 189–193.

D onoso, M.A., Munoz-Calvo, M.T., Barrios, V., Garrido, G., Hawkins, F., Argente, J. “Increased circulating adiponectin levels and decreased leptin/soluble leptin receptor ratio throughout puberty in female ballet dancers: association with body composition and the delay in puberty.” Eur J Endocrinol, 162(2010): 905–911.

Gutiérrez-Medina, S., Gavela-Pérez, T., Domínguez-Garrido, M.N., Gutiérrez-Moreno, E., Rovira, A., Garcés, C., Soriano-Guillén, L. “The influence of puberty on vitamin D status in obese children and the possible relation between vitamin D deficiency and insulin resistance.” J Pediatr Endocrinol Metab, 10(2014): 1515.


GOST Style Citations


1. Lee, H.S., Kim, Y.J., Shim, Y.S., Jeong, H.R., Kwon, E., Hwang, J.S. “Associations between serum vitamin D levels and precocious puberty in girls.” Ann Pediatr Endocrinol Metab, 19(2) (2014): 91–95.

2. D iVall, S.A., Radovick, S. “Pubertal development and menarche.” Ann NY Acad Sci, 1135(2008): 19–28.

3. Herbison, A.E., Moenter, S.M. “Depolarising and hyperpolarising actions of GABA(A) receptor activation on gonadotropinreleasing hormone neuron requirements for puberty, ovulation, and fertility.” Endocrinology, 149(2) (2008): 597–604.

4. D icken, C.L., Israel, D.D., Davis, J.B., Sun, Y., Shu, J., Hardin, J., Neal-Perry, G. “ Peripubertal vitamin D3 deficiency delays puberty and disrupts the estrous cycle in adult female mice.” Biol of Reprod, 87(2) (2012): 51.

5. E yles, D.W., Smith, S., Kinobe, R., Hewison, M., McGrath, J.J. “Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain.” J Chem Neuroanat, 29(1) (2005): 21–30.

6. W alker, D.M., Juenger, T.E., Gore, A.C. “Developmental profiles of neuroendocrine gene expression in the preoptic area of male rats.” Endocrinology, 150(5) (2009): 2308–2316.

7. Gezen-Ak, D., Dursun, E., Yilmazer, S. “The effects of vitamin D receptor silecing on the expression of LVSCC -A1C and the release of NGF in cortical neurons.” PLoS One, 6(3) (2011): e17553.

8. M alinina, E., Druzin, M., Johansson, S. “Differential control of spontaneous and evoked GABA release by presynaptic L-type Ca2+ channel in the rat medial preoptic nucleus.” J Neurophysiol, 104(1) (2010): 200–209.

9. Kinuta, K., Tanaka, H., Moriwake, T., Aya, K., Kato, S., Seino, Y. “Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads.” Endocrinology, 141(4) (2000): 1317–1324.

10. Long, J.-R., Xu, H., Zhao, L.-J., Liu, P.-Y., Shen, H., Liu, Y.-J., Xiong, D.-H., Xiao, P., Liu, Y.-Z., Dvornyk, V., Li, J.-L., Recker, R. R., Deng, H.-W. “The oestrogen receptor a gene is linked and/or associated with age of menarche in different ethnic groups.” J Med Genet, 42(2005): 796–800.

11. Ku, S.Y., Kang, J.W., Kim, H., Kim, Y.D., Jee, B.C., Suh, C.S., Choi, Y.M., Kim, J.G., Moon, S.Y.,

Kim, S.H. “Age at menarche and its influencing factors in North Korean female refugees.” Hum Reprod, 2(3) (2006): 883–886.

12. E lks, C.E., Perry, J.R., Sulem, P., Chasman, D.I., Franceschini, N., He, C., Lunetta, K.L., Visser, J.A., Byrne, E.M., Cousminer, D.L. “Thirty new loci for age at menarche identified by a meta-analysis of genome-wide associations studies.” Nat Genet, 42(2010): 1077–1085.

13. He, C., Zhang, C., Hunter, D.J., Hankinson, S.E., Buck-Louis, G.M., Hediger, M.L., Hu, F.B. “Age at menarche and risk of type 2 diabetes: results from 2 large prospective cohort studies.” Am J Epidemiol, 171(2010): 334–344.

14. D ossus, L., Allen, N., Kaaks, R., Bakken, K., Lund, E., Tjonneland, A., Olsen, A., Overvad, K., Clavel-Chapelon, F., Fournier, A. “Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition.” Int J Cancer, 127(2010): 442–451.

15. Golub, M.S., Collman, G.W., Foster, P.M., Kimmel, C.A., Rajpert-De Meyts, E., Reiter, E.O., Sharpe, R.M., Skakkebaek, N.E., Toppari, J. “Public health implications of altered puberty timing.” Pediatrics, 121(3) (2008): 218–230.

16. Villamor, E., Marin, C., Mora-Plazas, M., Baylin, A. “Vitamin D deficiency and age at menarche: a prospective study.” Am J Clin Nutr, 94(2011): 1020–1025.

17. Grivas, T.B., Vasiliadis, E., Mouzakis, V., Mihas, C., Koufopoulos, G. “Association between adolescent idiopathic scoliosis prevalence and age at menarche in different geographic latitudes.” Scoliosis, 1(2006): 9.

18. Gilbert-Diamond, D., Baylin, A., Mora-Plazaz, M., Marin, C., Arsenault, J.E., Hughes, M.D., Willett, W.C., Villamor, E. “Vitamin D deficiencyand banthropometric indicators of adiposity in school-age children: a prospective study.” Am J Clin Nutr, 92(2010): 1446–1451.

19. D avison, K.K., Susman, E.J., Birch, L.L. “Percent Body fat at age 5 predicts earlier pubertal development among girls at age 9.” Pediatrics, 111(2003): 815–821.

20. Lee, J.M., Appugliese, D., Kacirioti, N., Corwyn, R.F., Bradley, G.H., Lumeng, J.C. “Weight status in young girls and the onset of puberty.” Pediatrics, 119(2007): 624–630.

21. M artini, L.A., Wood, R.J. “Vitamin D status and the metabolic syndrome.” Nutr Rev, 64(2006): 479–486.

22. C hew, A., Harris, S.S. “Does vitamin D affect timing of menarche?” Nutr Rev, 71(3) (2013): 189–193.

23. D onoso, M.A., Munoz-Calvo, M.T., Barrios, V., Garrido, G., Hawkins, F., Argente, J. “Increased circulating adiponectin levels and decreased leptin/soluble leptin receptor ratio throughout puberty in female ballet dancers: association with body composition and the delay in puberty.” Eur J Endocrinol, 162(2010): 905–911.

24. Gutiérrez-Medina, S., Gavela-Pérez, T., Domínguez-Garrido, M.N., Gutiérrez-Moreno, E., Rovira, A., Garcés, C., Soriano-Guillén, L. “The influence of puberty on vitamin D status in obese children and the possible relation between vitamin D deficiency and insulin resistance.” J Pediatr Endocrinol Metab, 10(2014): 1515.





DOI: http://dx.doi.org/10.18370/2309-4117.2015.22.47-49

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