Detection of proliferative potential in ectopic endometrium in women with different forms of endometriosis

Н. Ф. Захаренко

Abstract


To investigate the proliferative potential in ectopic endometrium was determined by immunohistochemistry the expression of proliferating cell nuclear antigen (PCNA), which is considered a factor in the growth of tumors. In ectopic endometrium also determined the expression of carcino-embryonic antigen (CEA), which is considered a predictor of malignancy of tumors.

Histological examination of extirpation uterus was conducted in 35 women of first groups with internal endometriosis, the second group consisted of 52 patients with external endometriosis and the third group consisted of 19 patients with extragenital endometriosis, which was performed resection of endometriosis lesions.

The study revealed that the majority of endometrial ectopia was CEA-negative, on the basis of which we can speak of a low propensity to malignancy potential of all forms of endometriosis.

Lack of expression of CEA in all patients with extragenital endometriosis may indicate the lowest probability of malignant transformation of endometrioid heterotopias is in their extragenital localization


Keywords


ectopic endometrium; endometriosis; proliferating cell nuclear antigen; carcino-embryonic antigen

References


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GOST Style Citations


1. Адамян, Л.В. Оптимизация лечения наружного генитального эндометриоза с использованием антиоксидантных средств / Л.В. Адамян, О.Н. Логинова, М.М. Сонова // Медицина и образование в Сибири (сетевое издание), 14.00.00: Медицинские и фармацевтические науки. — 2012. — № 4. — C. 74–76.

2. Лизин, М.А. Сучасні погляди на етіологію, патогенез, клініку, діагностику генітального ендометріозу / М.А. Лизин, Н.Б. Николин, Т.М. Дрінь // Галицький лікар. вісн. — 2006. — № 2. — С. 113–119.

3. Beutel, M.E., Weidner, K., Brohler, E. “Chronic pelvic pain of Women and its Co-Morbidity.” Geburtsh Frauenheilk, 65(2005): 61–67.

4. Brown, M.A., Edwards, S., Hoyle, E., Campbell, S., Laval, S., Daly, A.K., et al. “Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis.” Hum Mol Genet, 9(2000): 1563–1566.

5. Flor, H., Turk, D.C., eds. Chronic pain: An Integrated Biobehavioral Approach. London. Informa Healthcare Publishing Group (2011).

6. Hassa, H. “Apoptosis patterns in eutopic and ectopic endometrium, adhesions and normal-looking peritoneum from women with or without endometriosis.” Arch Gynecol Obstet, 2(280) (2009): 195–199.





DOI: http://dx.doi.org/10.18370/2309-4117.2015.22.22-24

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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)